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| Number | Title | Issue Date |
| 8097733 | Pyrazole derivatives as 5-LO-inhibitors The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same. ... | 01/17/2012 |
| 7932401 | 1,5-diphenylpyrazoles Novel 1,5 diphenylpyrazole derivatives of the formula (I), in which R1-R6 have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibit... | 04/26/2011 |
| 7919633 | Process for preparation of celecoxib There is provided a process for preparation of celecoxib by reacting 4,4,4-trifluoro-1-[4-(methyl)phenyl]butane-1,3-dione with 4-sulphonamidophenylhydrazine or its salt in a solvent medium that contains an alkyl ester. There is also provided a process for the purifi... | 04/05/2011 |
| 7906657 | 1,5-diphenylpyrazoles II as HSP90 inhibitors Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, reg... | 03/15/2011 |
| 7812176 | Processes for preparing substituted N-aryl-N′-[3-(1H-pyrazol-5-YL) phenyl] ureas and intermediates thereof The present invention is directed to processes for the preparation of substituted phenylpyrazole ureas of Formula (I), that are useful as 5-HT2A serotonin receptor modulators for the treatment of disease. ... | 10/12/2010 |
| 7759497 | Synthesis of diaryl pyrazoles A process for the qualitative preparation of 3-haloalkyl-1H-pyrazoles suitable for efficient, high payload commercial application. ... | 07/20/2010 |
| 7700786 | Pyrazole derivative, intermediate therefor, processes for producing these, and herbicide containing these as active ingredient The present invention provides a pyrazole derivative of the general formula (1), which has an excellent efficacy as an active component for a herbicide, an intermediate for the production thereof, processes for the producti... | 04/20/2010 |
| 7572922 | Substituted pyrazoles, compositions containing such compounds and methods of use The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus. | 08/11/2009 |
| 7465808 | CCK-1 receptor modulators There are provided by the present invention certain pyrazole based CCK-1 receptor modulators. ... | 12/16/2008 |
| 7435753 | Substituted arylpyrazoles This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides. ... | 10/14/2008 |
| 7361679 | 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same The present invention relates to a 2-phenyl-3-heteroarylpropionic acid derivative or a salt thereof, and also relates to a pharmaceutical agent and a VLA-4 and/or LPAM-1 antagonist each of which contains the same as an active ingredient. ... | 04/22/2008 |
| 7348342 | Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of inflammatory diseases. ... | 03/25/2008 |
| 7282516 | 4-cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 a... | 10/16/2007 |
| 7247734 | 3,4-diarylpyrazoles and their use in the therapy of cancer The present invention pertains to the use of certain 3,4-diarylpyazoles of formula (I), both in vitro and in vivo, to inhibit heat shock protein 90 (HSP90), and in the treatment of conditions mediated by HSP90, including, for example, cancer; wherein: Ar3 | 07/24/2007 |
| 7244753 | Cyclooxygenase-2 selective inhibitors, compositions and methods of use The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulat... | 07/17/2007 |
| RE39708 | Estrogen receptor modulators Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating es... | 06/26/2007 |
| 7230010 | 1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: where... | 06/12/2007 |
| 7202196 | Selective herbicide comprising a tetrazolinone derivative The invention relates to novel herbicidal synergistic active compound combinations comprising a known tetrazolinone derivative and known herbicidally active compounds and/or safeners, which compositions can be used with particularly good results for the selective co... | 04/10/2007 |
| 7202232 | Acrylonitrile derivatives for inflammation and immune-related uses What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein... | 04/10/2007 |
| 7183306 | Pyrazole derivatives A compound of the formula (I): wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, etc.; R3 is lower alkoxy, etc.; ... | 02/27/2007 |
| 7144910 | Sulfonamides, sulfamates and sulfamides as gamma-secretase inhibitors Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease. ... | 12/05/2006 |
| 7141678 | Synthesis of diaryl pyrazoles A process for the qualitative preparation of 3-haloalkyl-1H-pyrazoles suitable for efficient, high payload commercial application. ... | 11/28/2006 |
| 7132544 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 ... | 11/07/2006 |
| 7112601 | Cycloalkyl heterocycles for treating hepatitis C virus Compounds of Formula I are disclosed which inhibit hepatitis C NS5B RNA-dependent RNA polymerase and are useful for treating hepatitis C. Compositions and methods of using these compounds are also disclosed ... | 09/26/2006 |
| 7112605 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof The invention relates to sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones compounds having formula (I) wherein R1 is selected from the group consisting of 4-methylsulfonyl, 4-aminosulfonyl, hydrogen, 2... | 09/26/2006 |
| 7094906 | Processes for preparing pesticidal intermediates The present invention relates to processes for the preparation of a compound of the formula wherein W is nitrogen or —CR3; R1 is halogen, haloalkyl, haloalkoxy, R4S(O)n | 08/22/2006 |
| 7071220 | N-substituted benzothiophenesulfonamide derivatives The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on cause... | 07/04/2006 |
| 7041694 | Cyclooxygenase-2 inhibition Selective inhibitors of cyclooxygenase-2 are used to treat liver disease and in combination with anti-viral drugs to treat virus-caused liver disorders. Selective inhibitors of cyclooxygenase-2 which also inhibit the synthesis of cyclooxygenase-2 improve over the ef... | 05/09/2006 |
| 7019144 | 1,2,4-Triazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 1,2,4-Triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided. ... | 03/28/2006 |
| 6964978 | Solid-state form of celecoxib having enhanced bioavailability The selective cyclooxygenase-2 inhibitory drug celecoxib is provided in amorphous form. Also provided is a celecoxib drug substance wherein the celecoxib is present, in at least a detectable amount, as amorphous celecoxib. Also provided is a celecoxib-crystallizatio... | 11/15/2005 |
| 6960609 | 1-diphenylmethyl-pyrazole derivatives as opioid receptor ligands This invention relates to 1-diphenylmethyl-pyrazole derivatives of formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, R4 and R5 are de... | 11/01/2005 |
| 6953578 | Materials and methods for detection and treatment of immune system dysfunctions The subject invention concerns novel materials and methods for the treatment and/or prevention of autoimmune disease. In a specific embodiment, elevated production of prostaglandin synthase-2 (PGS-2) is correlated with autoimmune dysfunction. ... | 10/11/2005 |
| 6951949 | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is s... | 10/04/2005 |
| 6949536 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ... | 09/27/2005 |
| 6919462 | Process for preparing pesticidal intermediates A process for preparing pesticides or pesticidal intermediates, particularly 5-amino-1 aryl-3-cyanopyrazoles, having the formula said process comprising reacting a compound having the formula | 07/19/2005 |
| 6916839 | Pyrazolylarylalkines The present invention relates to pyrazolylarylalkines and to their use, to a process for preparing pyrazolylarylalkines and also to intermediates. ... | 07/12/2005 |
| 6914069 | Pharmaceutically active compounds and methods of use The invention provides substituted pyrazole compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility. ... | 07/05/2005 |
| 6906196 | Processes for the preparation of 1,5-diaryl-3-substituted-pyrazoles Provided are processes and chemical intermediates useful for preparing a compound of the formula I wherein X is selected from the group consisting of C1-C6 | 06/14/2005 |
| 6858639 | 3-Arylphenyl sulfide derivative and insecticide and miticide 3-Arylphenyl sulfide derivatives represented by general formula (I): (wherein R is a C2-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 ... | 02/22/2005 |
| 6846838 | Ureido-substituted aniline compounds useful as serine protease inhibitors Compounds having the formula (I), or pharmaceutically-acceptable salts, hydrates or prodrugs thereof, are effective as inhibitors of Factor VIIa. ... | 01/25/2005 |
