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| Number | Title | Issue Date |
| 8367846 | Method of producing 2-alkyl-3-aminothiophene derivative The present invention provides a method of producing 2-alkyl-3-aminothiophene derivative represented by Formula (4), the method comprising oxidizing a compound represented by the following Formula (1) to produce a compound represented by the following Formula (3) an... | 02/05/2013 |
| 8318951 | Stem cell differentiating agents and uses therefor The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and ... | 11/27/2012 |
| 8227620 | Pharmaceutical compounds Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: R is a group selected from C | 07/24/2012 |
| 8097732 | 1-arylpyrazoles and their use as pesticide Disclosed are compounds of formula (I) or pesticidally acceptable salts thereof, wherein, for example, W is ═N—, ═CH—, ═CR7— or ═C(NR8R9)—, R7 is halogen, R8 and R9 are independently o... | 01/17/2012 |
| 7659407 | Pharmaceutical compounds Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: R is a group selected from: C | 02/09/2010 |
| 7456295 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles The present invention demonstrates the synthesis of a new pyrazole-containing monomer by means of an easily implemented two-step process. This monomer can be electropolymerized to yield a stable n-doping polymer that may easily be electrochemically characterized. It... | 11/25/2008 |
| 7396944 | Thiophene derivatives, their manufacture and use as pharmaceutical agents Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as we... | 07/08/2008 |
| 7396929 | Synthesis of 3-amino-4-substituted pyrazole derivatives This application discloses a novel process to synthesize 3-amino-4-substituted pyrazole derivatives, which may be used, for example, as intermediates to prepare compounds having, for example, pharmaceutical utility. ... | 07/08/2008 |
| 7348342 | Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of inflammatory diseases. ... | 03/25/2008 |
| 7265112 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasse... | 09/04/2007 |
| 7247635 | Pyrazole derivative Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors conta... | 07/24/2007 |
| 7244757 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R1, R3, R4, R5, R6, R7 and R8 are as defined... | 07/17/2007 |
| 7241793 | Phenyloxyalkanonic acid derivatives as hPPAR activators A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein: ... | 07/10/2007 |
| RE39681 | 1-(4-sulfamyaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2 Compounds of the formula wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula II: ... | 06/05/2007 |
| 7195649 | N-aryl-4,5-diaminopyrazoles and dyes containing said compounds N-Aryl-4,5-diaminopyrazole of formula (I) or a physiologically compatible salt thereof of an organic or inorganic acid wherein R1 and R2 independently of each other denote a hydrogen atom, a straight... | 03/27/2007 |
| 7192976 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and... | 03/20/2007 |
| 7173129 | Sulfonamide-substituted chalcone derivatives and their use to treat diseases The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the ... | 02/06/2007 |
| 7148226 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The ... | 12/12/2006 |
| 7138361 | Herbicidal heterocycles Compounds of Formula (1), their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein A, R1, R2... | 11/21/2006 |
| 7105564 | Pharmaceutical composition comprising a dual antagonist against PGD/TXAreceptors having a [2.2.1] or [3.1.1] bicyclic skeleton The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D2 receptor and pharmaceutical compositions comprising them. A compound of the formula (I): | 09/12/2006 |
| 7091350 | Diaminopyrazole derivatives and their use for oxidation dyeing of keratinous fibres The invention relates to diaminopyrazole derivatives having the following structure (I), wherein R1 represents an alkyl or alkenyl radical bearing at least one substituent selected from among OR, NRR′, SR, SOR, SO2R, COOR, CONRR′, PO(OH) | 08/15/2006 |
| 7078531 | Process for obtaining enantiomers of thienylazolylalcoxyethanamines A process is described for the preparation of a precursor alcohol of (±)-2-[thienyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethyletanamine and in general for thienylazolylalcoxyethanamines and their enantiomers. The process involves asymmetric addition of a metala... | 07/18/2006 |
| 7034154 | Synthesis of substituted pyrazolopyrimidines Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. ... | 04/25/2006 |
| 7034049 | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3–C6 cycloalkyl group optionally substituted by a straight or branched C1–C6 alkyl or arylalkyl group; R1 is a straig... | 04/25/2006 |
| 6998415 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. ... | 02/14/2006 |
| 6979742 | Process for obtaining enantiomers of thienylazolylalcoxyethanamines A process is described for the preparation of a precursor alcohol of (±)-2-[thienyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethyletanamine, and more generally for thyenylazolylalcoxyethanamines and their enantiomers. The process involves the asymmetric reduction o... | 12/27/2005 |
| 6965036 | Intermediates for guanidine mimics as factor Xa inhibitors The present application describes intermediates for nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D—E represent guanidine m... | 11/15/2005 |
| 6958339 | Pyrazole derivative The present invention is directed to drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-activated calcium channel inhibitory effect and medicinal co... | 10/25/2005 |
| 6949536 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ... | 09/27/2005 |
| 6916798 | Inhibitors of GSK-3 and uses thereof The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The inventi... | 07/12/2005 |
| 6911452 | Spiroazacyclic compounds as monoamine receptor modulators The present invention relates to 1-oxa-3,8-diaza-spiro[4.5]decan-2-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of treating a disease conditio... | 06/28/2005 |
| 6897232 | Pyrazole derivatives, their preparation and their use in pharmaceuticals The present invention relates to pyrazole derivatives of the formula I, their preparation and their use in pharmaceuticals: in which X, R1, R1a, R2, R3, R4 and n a... | 05/24/2005 |
| 6706711 | Pyrazole derived kinase inhibitor Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein R1, R2, T, n and Q are as described in the specification. The compounds are useful for treatin... | 03/16/2004 |
| 6660732 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 12/09/2003 |
| 6656933 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 12/02/2003 |
| 6610726 | Compositions and agents for modulating cellular proliferation and angiogenesis The invention is directed to pharmaceutical compositions containing small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, useful for promoting, for example, vascularization of tissues or ... | 08/26/2003 |
| 6605637 | Lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping reactive oxygen speci... | 08/12/2003 |
| 6593358 | Thienyl-pyrazoles and their use for controlling pests The present invention relates to compounds of the formulae (Ia) and (Ib) ##STR1## wherein R1 represents C1-10 alkyl which may be unsubstituted or substituted with halogen, or represents C2-4 alkoxyalkyl, C2-4 hy... | 07/15/2003 |
| 6593357 | Pyrazole compositions useful as inhibitors of ERK Described herein are compounds that are useful as protein kinase inhibitors having the formula: ##STR1## where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviate... | 07/15/2003 |
| 6569860 | Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as IP antagonists This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I): ##STR1## wherein G2 is a heteroaryl group containing one or two nitrogen atoms substituted with a carboxylic acid group, said hetero... | 05/27/2003 |
