Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 8039639 | Kinase inhibitors and methods of use thereof A compound of Formula II and salts thereof are useful in the preparation of a compound of Formula I and pharmaceutically acceptable salts and prodrugs thereof. ... | 10/18/2011 |
| 7741494 | Histone deacetylase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein. ... | 06/22/2010 |
| 7622594 | Glucocortioid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (IA) and (IB) wherein R1, R2, R3, A, B, C, D, and E are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such ... | 11/24/2009 |
| 7605272 | IGF-1R inhibitor The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR | 10/20/2009 |
| 7449586 | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof The invention relates to novel processes for the preparation of small molecule antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”) and intermediates thereof. ... | 11/11/2008 |
| 7419989 | Indazole-carboxamide compounds The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 recep... | 09/02/2008 |
| 7402606 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle ... | 07/22/2008 |
| 7399765 | Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute... | 07/15/2008 |
| 7396833 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of ... | 07/08/2008 |
| 7365211 | Heterocyclic GABAA subtype selective receptor modulators This invention relates to a method for modulating α2 subtype GABAA receptors with heterocyclic compounds of formula I, and salts, solvates and prodrugs thereof. The invention further relates to said heterocyclic compounds and pharmaceutical co... | 04/29/2008 |
| 7332149 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient... | 02/19/2008 |
| 7304060 | Indazolyl-substituted pyrroline compounds as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or am... | 12/04/2007 |
| 7271190 | Indazole compounds as β3 adrenoceptor agonist A compound represented by the general formula I: I wherein R1 represents hydrogen, etc. R2 represents NHSO2R3, etc., provided that R3 represents C1-6 alkyl, etc. R5 represents hydrogen, etc. R6 | 09/18/2007 |
| 7250436 | Indazole-aminoacetonitrile derivatives having special pesticidal activity The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances gi... | 07/31/2007 |
| 7232912 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or i... | 06/19/2007 |
| 7223772 | Pyrazolopyridine derivatives as selective cox-2 inhibitors The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from the gr... | 05/29/2007 |
| 7217728 | Diaminopropionic acid derivatives A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds. ... | 05/15/2007 |
| 7214699 | Indazole derivatives as CRF antagonists This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II: wherein R3 is optionally substituted aryl or heteroaryl, R1... | 05/08/2007 |
| 7211594 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith This invention is generally directed to Indazole Derivatives having the following structure: or pharmaceutically acceptable salt thereof, wherein R1, R2 and A are as defined herein. Such com... | 05/01/2007 |
| 7205299 | Indole derivatives having an apoptosis-inducing effect The invention relates to indole derivatives which are used as drugs for treating tumor diseases, in particular when there is drug resistance against other active compounds and where there is a metastasizing carcinoma. ... | 04/17/2007 |
| 7199147 | Rho kinase inhibitors A compound represented by the formula (1): wherein R1—X— indicates that 1 to 4 R1—X— groups are present which may be the same or different, the rin... | 04/03/2007 |
| 7196082 | Ophthalmic compositions for treating ocular hypertension This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the us... | 03/27/2007 |
| 7141587 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit un... | 11/28/2006 |
| 7125863 | Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t... | 10/24/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7060841 | Process for preparing 1-methylindazole-3-carboxylic acid The invention provides a process for preparing 1-methylindazole-3-carboxylic acid of formula (I): which comprises reacting a methylating agent with indazole-3-carboxylic acid of formula (VI): ... | 06/13/2006 |
| 7053107 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use Indazole compounds that modulate and/or inhibit the ophthalmic diseases and the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereb... | 05/30/2006 |
| 6998489 | Methods of making indazoles Methods of making indazoles are described. The methods involved reacting an aromatic aldehyde with a nitrogen source to form a nitroso aromatic aldehyde. The nitroso aromatic aldehyde is reacted with a reducing agent to form an indazole which ultimately can be used ... | 02/14/2006 |
| 6962929 | Pentafluorobenzenesulfonamides and analogs The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states... | 11/08/2005 |
| 6956036 | 6-hydroxy-indazole derivatives for treating glaucoma Substituted 1-(α-alkyl-ethylamino)-1H-indazol-6-ols useful for lowering and controlling IOP and treating glaucoma are disclosed ... | 10/18/2005 |
| 6943186 | Methods of treating sepsis The present invention features a method for treating sepsis. The method includes administrating to a subject in need thereof an effective amount of a fused pyrazolyl compound of formula (I): A is H, C1˜C | 09/13/2005 |
| 6933390 | Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of fur... | 08/23/2005 |
| 6919461 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or i... | 07/19/2005 |
| 6897231 | Indazole derivatives as JNK inhibitors and compositions and methods related thereto Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R1, R2 and A are as defined... | 05/24/2005 |
| 6891044 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit un... | 05/10/2005 |
| 6884890 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit un... | 04/26/2005 |
| 6875765 | Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are described. In one embodiment, the compound is described by the generalized s... | 04/05/2005 |
| 6864254 | Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular dis... | 03/08/2005 |
| 6858638 | Substituted indazoles, compositions containing them, method of production and use Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particlar in oncology. ... | 02/22/2005 |
| 6794518 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer ... | 09/21/2004 |
