Class 548/360.1 - Bicyclo ring system having the diazole ring as one of the cyclos (e.g., 2, 4-dichloro-5-nitrophenyl-4,5,6,7-tetrahydro-2H-indazole, etc.)

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the polycyclo ring system consists of
No. of patents: 126
Last issue date: 08/30/2011

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Number	Title	Issue Date
8008505	Indazole or 4,5,6,7-tetrahydro-indazole derivatives This invention relates to novel indazole or 4,5,6,7-tetrahydro-indazole derivatives of formula I wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically accepta...	08/30/2011
7858809	Process for production of pyrazole-fused ring derivatives Intermediates useful for the synthesis of pyrazole-fused ring derivatives, such as 7-phenylpyrazolo [1,5-a]pyridine derivatives, and method for producing the same. Method for producing compound represented by the general formula (II), wherein Z1 and Z	12/28/2010
7410992	Ophthalmic compositions for treating ocular hypertension This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the ...	08/12/2008
7365211	Heterocyclic GABAA subtype selective receptor modulators This invention relates to a method for modulating α2 subtype GABAA receptors with heterocyclic compounds of formula I, and salts, solvates and prodrugs thereof. The invention further relates to said heterocyclic compounds and pharmaceutical co...	04/29/2008
7358370	Benzene, pyridine, and pyridazine derivatives Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q	04/15/2008
7351831	Process for asymmetric intramolecular [3+2] cyclo-addition of hydrazones An intramolecular [3+2] cycloaddition reaction of a hydrazone is carried out under a mild condition with a high stereoselectivity and yield by reacting a hydrazone derivative in the presence of an asymmetric catalyst system obtained by mixing a zirconium alkoxide re...	04/01/2008
7282498	Substituted fused pyrroleoximes and fused pyrazoleoximes Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, ant...	10/16/2007
7282499	Sigma receptor inhibitors The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to some pyrazole derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy...	10/16/2007
7276611	Process for synthesizing beta-lactamase inhibitor intermediates There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are usefu...	10/02/2007
7250436	Indazole-aminoacetonitrile derivatives having special pesticidal activity The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances gi...	07/31/2007
7226941	Compound for treating angiogenesis The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells, and treating cell proliferating diseases or conditions. ...	06/05/2007
7196111	Pyrazolo[1,5a]pyrimidine compounds as antiviral agents The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and...	03/27/2007
7125869	Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the field...	10/24/2006
7125903	Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as Dantagonists The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. Th...	10/24/2006
7125990	Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu...	10/24/2006
7119115	Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncology The present invention relates to novel compounds derived from indazoles or indoles of formula (1) or formula (2), to methods for treating tumors or cancerous cells with compounds of formula (1) or formula (2) and to pharmacaetutical compositions comprising a pharmac...	10/10/2006
7112582	Bicyclic 6-alkylidene-penems as β-lactamase inhibitors The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B den...	09/26/2006
7112553	Pesticidal indazole or benzotriazole derivatives A compound of formula (I) wherein G is either (i) or (ii), where M1 or M2 is bonded to A; n is 0 or 1; when G is (i), D is S, NR7, CR8═CR9, CR8═N, CR8═N(O), N═CR9 or N(O)...	09/26/2006
7112590	Thrombin inhibitors The invention relates to compounds that are heterocyclic derivatives of dipeptides and dipeptides mimetics and pharmaceutically acceptable salts thereof. The compounds are used as thrombin inhibitors ...	09/26/2006
RE39263	Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides of the general formula (I) useful as herbicides. ...	09/05/2006
7071182	Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in repro...	07/04/2006
7049307	Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in repro...	05/23/2006
6956052	Substituted pyrazolyl compounds for the treatment of inflammation The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthri...	10/18/2005
6897208	Benzimidazoles The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compo...	05/24/2005
6867202	Treatment of insulin resistance This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, where the variables are defined in the specification, or the...	03/15/2005
6770664	Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: wherein Y is a radical of Formulae II or III: in which the substituents have the meaning indi...	08/03/2004
6747046	Substituted N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl) derivatives, their production and use as pharmaceutical agents Substituted N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl) derivatives, their production, as well as intermediate products for their production, and the use as pharmaceutical agents for treating various diseases are described. ...	06/08/2004
6630487	Treatment of insulin resistance with growth hormone secretagogues This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, ##STR1## where the variables are defined in the specification, or the stereoisomeric mixture...	10/07/2003
6613718	Aryl ether derivatives and processes for their preparation and herbicidal and desiccant compositions containing them Substituted aryl ether derived compounds represented by the general structure (I) are described. X and Y are independent of each other and are represented by hydrogen, halogen, cyano, nitro, (C1-4)alkyl, (C1-4)haloalkyl, or (C1-...	09/02/2003
6573219	Substituted heterocyclyl-2H-chromenes The invention relates to novel substituted heterocyclyl-2H-chromenes of the general formula (I) ##STR1## in which R1, R2, R3, R4, R5 Z are each as defined in the description, and to a process for thei...	06/03/2003
6545033	Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: ##STR1## or a salt thereof, where R1 is amino, hydrogen, alkyl, hydroxy, halo, alkoxy, alkylamino, dial...	04/08/2003
6448263	Treatment of insulin resistance with growth hormone secretagogues This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, ##STR1## where the variables are defined in the specification, or the stereoisomeric mixture...	09/10/2002
6395905	Tetrahydroindazole derivatives as ligands for GABA-A ଱ 5 receptors 4-oxo-tetrahydroindozole-3-carboxamide compounds according to Formula (I), or a pharmaceutically acceptable salt thereof, are GABA-A Alpha 5 ligands useful for enhancing cognition: ##STR1##...	05/28/2002
6362213	Cyclic AMP-specific phosphodiesterase inhibitors Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as ce...	03/26/2002
6358885	Substituted phenylheterocyclic herbicides This invention relates to certain phenylheterocyclic compounds, herbicidal compositions thereof and a method for their use as general and selective preemergent or postemergent herbicides or plant growth regulants....	03/19/2002
6350754	3-(cycloalkanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors The present invention relates to novel 3-(cycloalkano-heteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be usefu...	02/26/2002
6350749	Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof The present invention is to provide a compound of the formula: ##STR1## wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optio...	02/26/2002
6323315	Dolastatin peptides The present invention provides compounds of the formula ##STR1## where R1 -R5 are each, independently, a hydrogen atom or a normal or branched C1 -C6 -alkyl group; A is a methionyl, phenylalanyl or phenylglycyl ...	11/27/2001
6150532	Modulators of proteins with phosphotyrosine recognition units The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to their use for treatment of human an...	11/21/2000
6100398	Transition metal-catalyzed process for preparing N-aryl amine compounds Disclosed is a process for the preparation of N-aryl amine compounds, comprising reacting an amine compound with an arylating compound in the presence of a base and a transition metal catalyst under reaction conditions effective to form an N-aryl amine co...	08/08/2000

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Class 548/360.1 - Bicyclo ring system having the diazole ring as one of the cyclos (e.g., 2, 4-dichloro-5-nitrophenyl-4,5,6,7-tetrahydro-2H-indazole, etc.)