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| Number | Title | Issue Date |
| 7425639 | Process An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at a typical beta-adrenoceptors (also known as beta-3-adrenoceptors). ... | 09/16/2008 |
| 7399868 | 4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B | 07/15/2008 |
| 7309800 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/18/2007 |
| 7279498 | Substituted aryl amides as IP antagonists Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R1, R2, R3 and R4 are as defined in the speci... | 10/09/2007 |
| 7253289 | One-step process for the preparation of halide-free hydrophobic salts This invention describes a one pot, single-step process for the preparation of halide-free hydrophobic salts comprising polyalkylated imidazolium cations and various anions in accordance with the following structure, wher... | 08/07/2007 |
| 7189860 | One-step process for the preparation of halide-free hydrophobic salts This invention describes a one pot, single-step process for the preparation of halide-free hydrophobic salts comprising polyalkylated imidazolium cations and various anions in accordance with the following structure, wher... | 03/13/2007 |
| 7183434 | Process for the continuous quaternization of tertiary amines with an alkyl halide The present invention relates to a continuous process for the quaternization of tertiary amines with an alkyl halide. The process is performed at a temperature between 50° C. and 140° C. by reacting a tertiary amine and an alkyl halide in a tubular reactor at a pr... | 02/27/2007 |
| 7151118 | Biphenylcarboxylic amide derivatives as p38-kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/19/2006 |
| 7087599 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 08/08/2006 |
| 7081347 | Method for predicting cardiovascular events A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations.... | 07/25/2006 |
| 7064142 | Imidazonline compounds Compounds represented by the general formula (I): wherein Ar1 and Ar2 are each aryl or heteroaryl; R1 is lower cycloalkyl, —Ar3, or a group of the general formula (a)... | 06/20/2006 |
| 6998414 | Substituted arylamides as IP antagonists Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R1, R2, R3 and R4 are as defined in the specificati... | 02/14/2006 |
| 6939974 | Imidazole carbenes The disclosure herein relates to imidazole carbenes and imidazole carbene salts. The disclosure also relates to the synthesis of imidazole carbenes and imidazole carbene salts. The imidazole carbenes disclosed include those synthesized by reacting an imidazole halid... | 09/06/2005 |
| 6774240 | Process for preparing ambient temperature ionic liquids A process for preparing an ionic liquid or salt, formed by reaction between an organic base and an alkylating agent, wherein the alkylating agent is a fluorinated ester or an alkyl sulfonate, is described. Suitable organic bases include imidazoles, substituted imida... | 08/10/2004 |
| 6667310 | Substituted guanidine derivatives The present application provides guanidine derivatives of the formula (I) ##STR1## wherein R1, R2, R3, A and Z are as defined herein.... | 12/23/2003 |
| 6617454 | Process for the preparation of amine oxides The present invention provides a process for the preparation of amine oxide by reacting a tertiary or a secondary amine with hydrogen peroxide as an oxidant in the presence of a recyclable heterogeneous catalyst comprising a layered double hydroxide excha... | 09/09/2003 |
| 6521683 | Antistatic agents and resin compositions incorporated therein Antistatic agents for reducing and eliminating static electric charges on resins, particularly acrylic resins, including an antistatically effective amount of at least one substituted imidazolinium salt of alkylbenzene sulfonic acid having the formula: ... | 02/18/2003 |
| 6492356 | Acylguanidine derivatives as inhibitors of bone resorption and as vitronectin receptor antagonists The present invention relates to acylguanidine derivatives of formula (I) in which R1, R2, R4, R5, R6, A, m and n have the meanings indicated in the patent claims, their physiologically tolerable salt... | 12/10/2002 |
| 6395764 | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agnonists This invention involves compounds having the following structure: ##STR1## wherein: a) R1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R2 and R3 are each independently selected from hydrogen; unsubstituted C... | 05/28/2002 |
| 6380237 | Diphenylimidazolines The invention relates to novel diphenylimidazolines of the formula (I) ##STR1## in which Ar1, Ar2 and R are each as defined in the description, and a plurality of processes for their preparation and to their use for controlling animal pes... | 04/30/2002 |
| 6376765 | Electrolyte composition, photoelectric conversion device and photo-electrochemical cell An electrolyte composition comprising a compound represented by the following general formula (1): ##STR1## wherein R represents a substituent containing a --(CR1 R2 --CR3 R4 --O)n -- bond (in which R... | 04/23/2002 |
| 6316380 | Catalyst system comprising transition metal and imidazoline-2-ylidene or imidazolidine-2-ylidene This invention provides a catalyst system useful in many coupling reactions, such as Suzuki, Kumada, Heck, and amination reactions. The catalyst system of the present invention makes use of N-heterocyclic carbenes or their protonated salts. The compositio... | 11/13/2001 |
| 6232336 | Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine- and enamide-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, a method for the preparation of nitric oxide-releasing amidin... | 05/15/2001 |
| 6222046 | Tetraalkylfluoroformamidinium trifluoroacetate and preparation process of same The invention has disclosed a trifluoroacetoxylation agent and a preparation process of the agent, which is safe and ease to handle, very useful in industry, and represented by the formula (1); ##STR1## wherein R1 to R4 are a substit... | 04/24/2001 |
| 6172239 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharamaceutical compositions containing them The invention relates to compounds of the formula ##STR1## The compounds have agreat affinity for the neurotensin receptors.... | 01/09/2001 |
| 6162818 | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists This invention involves compounds having the following structure: ##STR1## wherein: a) R1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R2 and R3 are each independently selected from hydrogen; unsub... | 12/19/2000 |
| 6127396 | Imidazoline compounds The invention relates to a compound of formula (I): ##STR1## wherein: A represents an optionally substituted benzene ring, B represents an imidazoline ring of formula (Ia) or (Ib): ##STR2## X represents CR6, CR6 R7, N... | 10/03/2000 |
| 6127583 | Process for preparing acetylene derivative from a ketone compound A preparation process of an acetylene derivative comprising reacting a compound having a skeleton represented by the formula (1): ##STR1## in the molecular formula with a compound represented by the formula (2): ##STR2## wherein R1, R... | 10/03/2000 |
| 6066740 | Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives The present invention provides a process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydroyrimidine derivatives by preparing the corresponding activated 2-thio-subsituted-2-derivative in a two-step, one-pot procedure and by furth... | 05/23/2000 |
| 6040422 | Synthesis and use of amino acid fluorides as peptide coupling reagent The present invention is directed to a process for forming a peptide bond between a first amino acid having a free amino group and a protected carboxy group and a second amino acid or between a peptide having a free amino group and a blocking carboxy grou... | 03/21/2000 |
| 6025496 | Process for preparing heterocyclic carbenes A process for preparing heterocyclic carbenes of the ##STR1## in which R1, R2, R3 and R4 are individually saturated or unsaturated, straight chain, branched or cyclic, unsubstituted or substituted C1 | 02/15/2000 |
| 5977357 | Phenyl alkyl ketone substituted by cyclic amine and a process for the preparation thereof A novel process for the preparation of compounds of formula I ##STR1## by aminolysis of a p-halophenyl alkyl ketone of formula II ##STR2## with a cyclic amine of formula III ##STR3## in water at a temperature of at least 130° C., in which ... | 11/02/1999 |
| 5965579 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them The invention relates to compounds of the formula: ##STR1## Compounds of the above formula have a great affinity for the neurotensin receptors.... | 10/12/1999 |
| 5939449 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them The invention relates to compounds of the formula: ##STR1## The compounds have great affinity for the neurotensin receptors.... | 08/17/1999 |
| 5925665 | Imidazoline compounds Compound of formula (I): in which R is as defined in the description, as well as their isomers and their pharmaceutically acceptable acid additions salts. Medicinal products containing the same are useful as Imidazoline receptors ligand.... | 07/20/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5856513 | Process for the preparation of N-alkyl-N'-methylimidazolinium salt of organic acid An N-alkyl-N'-methylimidazolinium salt of an organic acid is prepared in high purity and in high yield by (a) preparing an N-alkyl-N'-methylimidazolinium methyl carbonate in a quaternization reaction by methylating an N-alkylimidazoline with dimethyl carb... | 01/05/1999 |
| 5849929 | Process for the preparation of imidazoline nitroxyl A process is provided for the preparation of imidazoline derivatives such as imidazoline nitroxyls and 1-hydroxy imidazoline.... | 12/15/1998 |
| 5750767 | Synthesis and use of amino acid fluorides as peptide coupling reagents The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting ... | 05/12/1998 |
| 5728839 | Metal complexes with heterocycles carbenes A complex of the formula La Mb Xc !n (A)n I as described in the application useful as homogenous catalysts.... | 03/17/1998 |
