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| Number | Title | Issue Date |
| 8034956 | Ionic liquid and method for producing the same, method for forming oxide film on metal surface, electrolyte capacitor and electrolyte An ionic liquid formed of a cationic component and an anionic component characterized in that the cationic component contains fluorine atoms. When defects of an oxide film formed on the surface of a metal are anodized by a two-electrode system under existence of the... | 10/11/2011 |
| 7351836 | Method of preparing 4-(imidazol-1-yl)benzenesulphonamide derivatives Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives of formula I, wherein R1 represents optionally substituted aryl or heteroaryl, which comprises treating a compound of formula II, wherein R1 has the same meaning def... | 04/01/2008 |
| 7297708 | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurologi... | 11/20/2007 |
| 7223871 | Process for preparing substituted imidazole derivatives and intermediates used in the process The invention relates to a process for preparing substituted imidazole derivatives of formula (I) and acid addition salts thereof in which formula Y is —CH2— or —CO—, R1 is H, halo o... | 05/29/2007 |
| 7166724 | Ionic liquids An ionic liquid of the formula K+A−, wherein K and A are as defined herein, can be used in such things as electrochemical cells, supercapacitors, hydraulic liquids, solvents, organic syntheses. ... | 01/23/2007 |
| 7153974 | Ionic liquids II An ionic liquid of the formula K+A− wherein K+ and A− are as defined herein, are suitable for use in electrochemical cells and capacitors. These ionic liquids can also be used in catalysis, as inert solvents, and as hy... | 12/26/2006 |
| 7018430 | Method of mass-coloring synthetic materials The present invention relates to a method of mass-coloring synthetic materials, which comprises using at least one pigment dye of formula (1) wherein R and R1 together form a phenyl or heteroaryl radical and R2 is hydrogen, or R1 and... | 03/28/2006 |
| 6998415 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. ... | 02/14/2006 |
| 6838476 | Imidazoles with anti-inflammatory activity Compounds of formula I wherein: one of X or Y represents N and the other represents C; R1 represents hydrogen, methyl, halogen, cyano, nitro, —CHO, —COCH3 or —COOR4; PR2 represents optionally-substituted aryl or hete... | 01/04/2005 |
| 6747175 | Chlorination of an aniline in a hydrofluoric medium The invention concerns a method for the synthesis of chlorinated aniline on the ring and comprising at least a sp3 hybridization carbon atom both perhalogenated and bearing a fluorine atom. Said method is characterized in that it comprises a step which consists in c... | 06/08/2004 |
| 6743816 | Imidazole derivatives with anti-inflammatory activity Novel imidazole derivatives of formula I and their salts, solvates and prodrugs, wherein the meanings of the different radicals are as shown in the description. Said compounds are useful as anti-inflammatory agents. ... | 06/01/2004 |
| 6723753 | Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle... | 04/20/2004 |
| 6562832 | Substituted imidazole compounds Novel 1,4,5-subsituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 05/13/2003 |
| 6515133 | Pharmaceutical compositions containing certain diarylimidazole derivatives Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. Many of the compounds are nove... | 02/04/2003 |
| 6509366 | Substituted imidazoles as selective modulators of Bradykinin B2 receptors Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein Y, R1, R2, R3, R4, R5, R6, R7 R7 ' are variables de... | 01/21/2003 |
| 6486156 | Chemical compounds This invention relates to compounds of formula (1), wherein substituents are defined in the description, that inhibit farnesylation of mutant ras gene products tough inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relate... | 11/26/2002 |
| 6426360 | 4,5-substituted imidazolyl compounds for the treatment of inflammation A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula ##STR1## wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, ... | 07/30/2002 |
| 6420375 | Fused ring compounds, process for producing the same and use thereof To provide a novel compound of the formula: ##STR1## [wherein A1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A2 is an aromatic ring which may be substituted, X is a divalent group, Y i... | 07/16/2002 |
| 6414159 | Method for preparation of a quaternary ammonium salt The present invention provides a method for preparation of a quaternary ammonium salt comprising reacting an alkyl halide with 2 equimolar amount or more per the alkyl halide of a pyridine compound or an N-lower alkyl imidazole at 120° C. to 350° C., an... | 07/02/2002 |
| 6358955 | Substituted imidazoles as subtype specific dopamine receptor ligands and pharmaceutical compositions containing such substituted imidazole Disclosed are compounds of the formula: ##STR1## wherein R1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R3 and R4 ar... | 03/19/2002 |
| 6329529 | Nitrogen-based halogenating agents and process for preparing halogen-containing compounds Disclosed are a fluorinating agent represented by the general formula (1): ##STR1## wherein R1 to R4 are a substituted or unsubstituted, saturated or unsaturated alkyl group or a substituted or unsubstituted aryl group, and can be th... | 12/11/2001 |
| 6316380 | Catalyst system comprising transition metal and imidazoline-2-ylidene or imidazolidine-2-ylidene This invention provides a catalyst system useful in many coupling reactions, such as Suzuki, Kumada, Heck, and amination reactions. The catalyst system of the present invention makes use of N-heterocyclic carbenes or their protonated salts. The compositio... | 11/13/2001 |
| 6300501 | Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase Inhibitors of protein farnesyl transferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infe... | 10/09/2001 |
| 6201001 | Imidazole antiproliferative agents Compounds of formula I ##STR1## inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.... | 03/13/2001 |
| 6177575 | Process for manufacture of imidazoles Imidazoles may be manufactured by reacting a glyoxal, ammonia, an aldehyde, and optionally a primary amine, in the presence of a Bronsted acid whose pKa is approximately equal to the pKa of the ammonium cation of the primary amine, or if the primary amine... | 01/23/2001 |
| 6140508 | Process for making 1,5-disubstituted imidazoles The present invention is directed to a process for synthesizing 1,5-disubstituted imidazoles, which are useful in the preparation of farnesyl-protein transferase inhibitors.... | 10/31/2000 |
| 6121260 | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. Many of the compounds are nove... | 09/19/2000 |
| 6103749 | Aryl imidazole compounds having phosphodiesterase IV inhibitory activity Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R1, R2, R3, R4, X1, X2 and Z are described herein. Th... | 08/15/2000 |
| 6080870 | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 06/27/2000 |
| 6069251 | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4- substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## wherein R1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R3 and R4 | 05/30/2000 |
| 6063930 | Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 05/16/2000 |
| 6046227 | Selective 댣 adrenergic agonists The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective 댣 receptor agonists useful in the treatment of Type II diabet... | 04/04/2000 |
| 5977155 | Imidazole-5-carboxamides Products of formula (1), wherein R1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R3 is particularly carboxy, acyl, h... | 11/02/1999 |
| 5977377 | Process for producing N-alkylimidazole Disclosed is a process for producing an N-alkylimidazole which comprises reacting an imidazole with an N-alkylating agent in an organic solvent in the presence of alkali particles having a specific surface area of 0.6 M2 /g or larger.... | 11/02/1999 |
| 5965054 | Nonaqueous electrolyte for electrical storage devices Improved nonaqueous electrolytes for application in electrical storage devices such as electrochemical capacitors or batteries are disclosed. The electrolytes of the invention contain salts consisting of alkyl substituted, cyclic delocalized aromatic cati... | 10/12/1999 |
| 5922751 | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same Novel compounds which are effective PDE IV inhibitors are disclosed The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to, e.g., PDE III inhibition. Preferred compounds are 3-(3-... | 07/13/1999 |
| 5811445 | Method of preventing abnormal stimulation of AT1 and AT2 receptors Products of formula (1), wherein R1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R3 is particularly carboxy, acyl, h... | 09/22/1998 |
| 5756527 | Imidazole derivatives useful as modulators of multi drug resistances The present invention relates to imidazole derivatives having formula 1 ##STR1## wherein: R1 is selected from the group consisting of: mono-,di-,and tri-substituted phenyl or thienyl, the substituents are selected from the group consisting... | 05/26/1998 |
| 5750767 | Synthesis and use of amino acid fluorides as peptide coupling reagents The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting ... | 05/12/1998 |
| 5741794 | Heterocyclic sulfonamide derivatives as antagonists of PAF and angiotensin II Compounds of formula (I), wherein: A represents: a) a --VR6 group wherein v is --C(.dbd.O), --C(.dbd.O)O--, --CH2 O--, --CH2 OC(.dbd.O)--, --C(.dbd.S)--, --CH2 OC(.dbd.O)NH--, --C(.dbd.S)O--, --CH2 S-... | 04/21/1998 |
