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| Number | Title | Issue Date |
| 7915426 | Imidazolium salts and their use of these ionic liquids as a solvent New 1,2,3- or 1,2,3,4- or 1,2,3,4,5- substituted imidazolium salts and their uses as solvent in catalyzed organic reactions, as well as compositions containing them and a transition metal compound. They can be used in the following reactions: the telomerisation of c... | 03/29/2011 |
| 7026357 | Diphenylurea compounds Compound of formula (I): and medicinal products containing the same are useful as dual α2/5-HT2c antagonist receptors. ... | 04/11/2006 |
| 6759387 | Compositions and methods for enhancing drug delivery across and into epithelial tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for delivery acr... | 07/06/2004 |
| 6528535 | Bicyclic inhibitors of protein farnesyl transferase The present invention provide compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable... | 03/04/2003 |
| 6524770 | Hexaaryl biimidazole compounds as photoinitiators, photosensitive composition and method of manufacturing patterns using the compounds A hexaaryl biimidazole compound useful as a photoinitiator, represented by Formula (I): ##STR1## wherein each R group represents an alkyl group which may be the same or different, and each X group is independently a fluorine or hydrogen. The compound... | 02/25/2003 |
| 6426360 | 4,5-substituted imidazolyl compounds for the treatment of inflammation A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula ##STR1## wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, ... | 07/30/2002 |
| 6407258 | Method for producing S-alkyl(aryl)-substituted imidazol derivatives The invention relates to a process for the preparation of compounds of the formula (I) ##STR1## in which R(2) and R(3) independently of one another are --SR(4) or --COOR(5) and R(1), R(4) and R(5) have the meaning indicated in the description, which ... | 06/18/2002 |
| 6395724 | Multibinding inhibitors of cyclooxygenase-2 Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently ... | 05/28/2002 |
| 6201001 | Imidazole antiproliferative agents Compounds of formula I ##STR1## inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.... | 03/13/2001 |
| 6153757 | Metalloproteinase inhibitors and intermediates useful for their preparation The invention relates to compounds of formula (1) ##STR1## wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms other than C* and N independently is unsubstituted... | 11/28/2000 |
| 6103749 | Aryl imidazole compounds having phosphodiesterase IV inhibitory activity Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R1, R2, R3, R4, X1, X2 and Z are described herein. Th... | 08/15/2000 |
| 6060603 | Synthetic antagonists based on angiotensin Disclosed are methods for modelling the three-dimensional structure (tertiary structure) of a ligand having one or more active sites employing a charge-transfer interaction. Also disclosed is a model for Angiotensin II derived from such method.... | 05/09/2000 |
| 5977377 | Process for producing N-alkylimidazole Disclosed is a process for producing an N-alkylimidazole which comprises reacting an imidazole with an N-alkylating agent in an organic solvent in the presence of alkali particles having a specific surface area of 0.6 M2 /g or larger.... | 11/02/1999 |
| 5929249 | Substituted imidazolyl-alkyethio-aldanoic acids Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m... | 07/27/1999 |
| 5922751 | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same Novel compounds which are effective PDE IV inhibitors are disclosed The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to, e.g., PDE III inhibition. Preferred compounds are 3-(3-... | 07/13/1999 |
| 5905152 | Preparation of aminomethyl-phenylimidazoles Aminomethyl-phenylimidazoles are produced by reaction of an ester of a hydroxymethyl-phenylimidazole with an amine. A particularly preferred ester is the acetate ester. The aminomethyl-phenylimidazoles have useful properties as highly selective partial ag... | 05/18/1999 |
| 5877196 | N-4-(imidazolyl or pyrazolyl)phenyl(oxy, sulfinyl, sulfenyl or sulfonyl)alkyl!carboxamides, sulfonamides or phosphoramides having antiarrhythmic properties The present invention relates to substituted ω-phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl! alkyl, alkenyl or alkynyl!amine carboxamides, sulfonamides and phosphonylamides which are useful as antiarrhythmic agents.... | 03/02/1999 |
| 5807878 | Tetrasubstituted imidazoles A compound of the formula ##STR1## wherein the substituents are defined in the specification useful for the treatment of cardiovascular disorders.... | 09/15/1998 |
| 5741794 | Heterocyclic sulfonamide derivatives as antagonists of PAF and angiotensin II Compounds of formula (I), wherein: A represents: a) a --VR6 group wherein v is --C(.dbd.O), --C(.dbd.O)O--, --CH2 O--, --CH2 OC(.dbd.O)--, --C(.dbd.S)--, --CH2 OC(.dbd.O)NH--, --C(.dbd.S)O--, --CH2 S-... | 04/21/1998 |
| 5728842 | Substituted imidazolyl-alkylthio-alkanoic acids Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m... | 03/17/1998 |
| 5721265 | Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells Agents useful for detecting hypoxic tumor cells are provided. The compounds have the structural formula (I) ##STR1## Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with th... | 02/24/1998 |
| 5646293 | Preparation of N-alkenylazoles A process for preparing N-alkenylazoles of the general formula I ##STR1## where X is CH--R6 or nitrogen, R1 and R2 are hydrogen or C1 - to C8 -alkyl, R3,R4,R5 and R6 | 07/08/1997 |
| 5620944 | Phenylimidazole derivatives, herbicides comprising said derivatives, and usages of said herbicides The present invention discloses phenylimidazole derivatives having herbicidal activities, represented by general formula (I) ##STR1## (R1 and R2 each represent an alkyl group or the like; R3 represents an alkoxy group... | 04/15/1997 |
| 5620999 | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R1 is selected from lower alkyl, lower haloalkyl,... | 04/15/1997 |
| 5616601 | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R1 -R6 are as described in the specifi... | 04/01/1997 |
| 5514811 | Process for synthesizing 4-halo-5-(hydroxymethyl) imidazole compounds A process for preparing, on an industrial scale, 4-halo-5-(hydroxymethyl) imidazole compounds that are useful as intermediates for medicines. A 4-chloro-5-(hydroxymethyl) imidazole compound, a 4-bromo-5-(hydroxymethyl) imidazole compound or a like compoun... | 05/07/1996 |
| 5484780 | Angiotensin II antagonists This invention provides novel phenyl and heterocyclic derivatives, their pharmaceutical formulations and their methods of use for antagonizing angiotensin II receptors in mammals.... | 01/16/1996 |
| 5482957 | Azole derivatives, process for their preparation and their use Azole derivatives, process for their preparation, and their use Azole derivatives of the formula (I) ##STR1## in which A, L, O, R1, X, Y, Z and q have the meanings given, process for their preparation, pharmaceutical preparations and the use of... | 01/09/1996 |
| 5462958 | Benzene derivatives and method of treating arteriosclerosis with benzene derivatives The present invention provides a novel benzene derivative useful as a preventive and medically treating medicine for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the benzene derivative as an active ingredient. The benzene de... | 10/31/1995 |
| 5395932 | 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## wherein X is oxygen, sulfur ##STR2## A is --CH2 -- or ##STR3## E and F may be --CH, oxygen, nitrogen or sulfur, and may not be the s... | 03/07/1995 |
| 5364944 | Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid compounds There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA2 and lipoxygenase, and their use in the treatment of inflammatory condit... | 11/15/1994 |
| 5338749 | Diaryl-substituted heterocyclic compounds, their preparation and drigs and cosmetics obtained therefrom Compounds of formula I ##STR1## and compounds of formula Ia ##STR2## where the substituents are as defined in the specification.... | 08/16/1994 |
| 5326780 | Imidazole derivatives having anti-HIV activity A novel imidazole derivatives of formula I: ##STR1## wherein R1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R2 is alkyl, optionally substituted aryl optionally substituted aralkyl, or optionally substituted hete... | 07/05/1994 |
| 5312927 | Preparation of imidazoles The present invention relates to preparation of imidazoles which are useful as pharmaceutical and agricultural chemicals. Specifically, the present invention relates to a process for preparing imidazoles of the formula (I): ##STR1## which compri... | 05/17/1994 |
| 5312828 | Substituted imidazoles having angiotensin II receptor blocking activity Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m... | 05/17/1994 |
| 5296609 | Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives The invention provides a new and efficient process for preparing 2,4(5)-substituted or 1,2,4-substituted imidazole derivatives. The invention also provides a process for preparing substituted aminoalkylimidazole derivatives, useful for the treatment of mammals... | 03/22/1994 |
| 5260278 | Diol-containing renin inhibitors The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the pe... | 11/09/1993 |
| 5254546 | Fused aryl substituted imidazole angiotensin II receptor inhibitors Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.... | 10/19/1993 |
| 5218124 | Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives as inhibitors of pla2 and lipoxygenase There are disclosed compounds of the formula A(CH2)n O--B wherein A is a group having the formula ##STR1## wherein X is --N-- or ##STR2## Z is ##STR3## R1 is hydrogen, lower alkyl or phenyl; R2 i... | 06/08/1993 |
| 5204352 | Compounds exhibiting anti-parasitic activity and a method for their use Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted quaternary heteroaromatic salts which include a positively charged ... | 04/20/1993 |
