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| Number | Title | Issue Date |
| 7737285 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 06/15/2010 |
| 7638637 | Orally available sphingosine 1-phosphate receptor agonists and antagonists The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I) wherein R11 | 12/29/2009 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7241790 | Compounds active in spinigosine 1-phosphate signaling The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure of Formula (I) wherein R | 07/10/2007 |
| 7189748 | Compounds and methods for treating insulin resistance and cardiomyopathy Novel compounds, compositions comprising compounds, and methods for methods for preparing and using compounds are described herein. Methods of treating or ameliorating various conditions, including insulin resistance, pancreatic beta cell apoptosis, obesity, pro-thr... | 03/13/2007 |
| 7186734 | Aryl imidazoles and related compounds as C5a receptor modulators The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the variables are defined herein. Such compounds are ligands of C5a receptors. Preferr... | 03/06/2007 |
| 7064217 | Agonists and antagonists of sphingosine-1-phosphate receptors The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I), wherein R1 | 06/20/2006 |
| 6979696 | Method for detecting a gram-negative bacterial autoinducer molecule This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: wherein m, A, X, Y, R1, R2, R3,... | 12/27/2005 |
| 6972287 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of the Formula (I) and a method of imaging amyloid deposits, as well... | 12/06/2005 |
| 6967196 | Sulfonamide compounds and uses thereof In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substit... | 11/22/2005 |
| 6958402 | 3-(imidazolyl)-2-alkoxypropanoic acids Compounds according to formula (I) wherein n is 0-3, R1 is optionally substituted C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4 | 10/25/2005 |
| 6949577 | Pharmaceuticals The present invention provides compounds of formula (I) as well as the use of such compounds in pharmaceutical compositions and methods of treatment. The compounds described herein represent a class of TAFIa in... | 09/27/2005 |
| 6949578 | Cycloalkyl alkanoic acids as integrin receptor antagonists The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of select... | 09/27/2005 |
| 6900161 | Azole or triazole derivatives, method for preparing same and use thereof as fungicides The invention concerns novel azole or triazole derivatives of formula (Ia) or (Ib), wherein: X, Ar1, Ar2, Ar3, A, B and R1 are such as defined in the description, the method for preparing same and their use as fungicides. ... | 05/31/2005 |
| 6872741 | Sodium channel modulators The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the pr... | 03/29/2005 |
| 6768024 | Triamine derivative melanocortin receptor ligands and methods of using same The invention provides triamine derivative melanocortin receptor ligands of the formula: wherein R1 to R8 and n have the meanings provided herein. The invention further provides methods of using the... | 07/27/2004 |
| 6713496 | 3-(imidazolyl)-2-alkoxypropanoic acids Compounds according to formula (I) wherein n is 0-3, R1 is optionally substituted C1-8 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4 | 03/30/2004 |
| 6706743 | β3 adrenergic receptor agonists and uses thereof The instant invention provides β3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and ... | 03/16/2004 |
| 6703425 | Sulfonamide derivatives The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders ##STR1##... | 03/09/2004 |
| 6677353 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 01/13/2004 |
| 6638962 | Cycloheptene compounds Compound of formula (I): ##STR1## wherein: X represents a bond or alkylene, CO, S(O)n, --S(O)n --A1 --, --CO--A1 --, --A--S(O)n --A'1 -- or --A1 --CO--A'1 --, ... | 10/28/2003 |
| 6632840 | Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them Monoacyl-substituted guanidines of formula III, or a salt or acid thereof, and their use as medicine or diagnostic aid: ##STR1## in which X(2) is ##STR2##... | 10/14/2003 |
| 6620826 | Endothelin receptor antagonists Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.... | 09/16/2003 |
| 6605608 | Amino acid derivatives and drugs containing the same as the active ingredient The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). ##STR1## The compounds of the formula (I) possess inhibitory activity of N-type calcium cha... | 08/12/2003 |
| 6602849 | Cyclic somatostatin analogs The present invention is directed to cyclic derivatives containing an imidazole cis amide bond mimetic which bind selectively to somatostatin receptor subtypes and the use thereof in treating conditions which can be treated by eliciting an agonist or anta... | 08/05/2003 |
| 6486191 | Nitrophenyl-sulphonyl-imidazoles and use thereof for controlling vegetable and animal pests Novel nitrophenyl-sulphonyl-imidazole of the formula (I) ##STR1## wherein X, R1, R2 and R3 have the meanings stated in the description, a process for the preparation of the novel substances and their use for controlling ve... | 11/26/2002 |
| 6458803 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 10/01/2002 |
| 6436999 | Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them Diacyl-substituted guanidines of the formula I ##STR1## are described where X(1) and X(2) are ##STR2## as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis... | 08/20/2002 |
| 6420613 | Process for preparing reductants of unsaturated organic compounds by the use of trichlorosilane and reducing agents A method of preparing a reduced product by efficiently reducing an unsaturated organic compound by using, as a reducing agent, a trichlorosilane which is industrially cheaply available and is easy to handle, and a reducing agent therefor. A reduced produc... | 07/16/2002 |
| 6407132 | Substituted imidazole derivatives and their use as histamine H3 receptor ligands Compounds of formula (I) and their pharmaceutically acceptable salts are useful as histamine H3 receptor ligands. R1 and R3 are optional substituents such as C1 to C6 alkyl. R2 represents a... | 06/18/2002 |
| 6380224 | Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders Amine and amide derivatives of the formula: ##STR1## which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing amines and amides of formula A as the active ingredient are described. The ... | 04/30/2002 |
| 6358955 | Substituted imidazoles as subtype specific dopamine receptor ligands and pharmaceutical compositions containing such substituted imidazole Disclosed are compounds of the formula: ##STR1## wherein R1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R3 and R4 ar... | 03/19/2002 |
| 6355665 | 1H-4(5)-substituted imidazole derivatives, their preparation and their use as histamine H3 receptor ligands A compound of the formula ##STR1## wherein R2 is an optionally substituted Cz to Cg alkylene or alkylene chain; R3 is C2 to C15 optionally substituted hydrocarbyl; X is a bond or --NR4... | 03/12/2002 |
| 6333425 | Malononitrile-derivative anion salts, and their uses as ionic conducting materials The invention is related to ionic compounds, derivatives of malononitrile, in which the anionic load has been displaced. An ionic compound disclosed by the invention includes an anionic portion combined with at least one cationic portion M+m in... | 12/25/2001 |
| 6331552 | Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations including them Substituted imidazolidine derivatives of the formula I, ##STR1## in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active com... | 12/18/2001 |
| 6326500 | Imidazole derivatives for blocking the release of arachidonic acid from phospholipids Compounds of formula (I) ##STR1## and salts thereof, wherein R1 is hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR13 R14, --N(R15)SO2 R16, haloalkoxy... | 12/04/2001 |
| 6255327 | Diphenyl-substituted heterocycles, processes for preparing them and their use as pharmaceutical compositions The invention relates to new diphenyl-substituted 5-ring heterocycles of general formula (I) ##STR1## wherein A, X and the groups R1, R2, R3, R4 and R5 are defined as in the claims, processes for prep... | 07/03/2001 |
| 6242637 | Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH2 | 06/05/2001 |
| 6215001 | Imidazole derivatives as therapeutic agents Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof in which R1 represents hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR13 R14, --N(R15)SO | 04/10/2001 |
| 6201001 | Imidazole antiproliferative agents Compounds of formula I ##STR1## inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.... | 03/13/2001 |
