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| Number | Title | Issue Date |
| 7649098 | Imidazole-based compounds, compositions comprising them and methods of their use Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I: | 01/19/2010 |
| 7361678 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 04/22/2008 |
| 7332608 | Anthranilamides and methods of their use The present invention is related to a process for preparing anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and p... | 02/19/2008 |
| 7323484 | Farnesyl transferase inhibitors The present invention is directed to compounds of the formula wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumor... | 01/29/2008 |
| 7271189 | 1H-imidazole derivatives as cannabinoid receptor modulators The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparati... | 09/18/2007 |
| 7235690 | Anthranilamides and methods of their use The present invention is related to anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations con... | 06/26/2007 |
| RE39634 | Bisarylimidazoly fatty acid amide hydrolase inhibitors The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain, particularly neuropathic pain, psychomotor disorder, hypertension, ca... | 05/15/2007 |
| 7164028 | Method for preparing β-alaninamides Cyanoacetamides of the formula: and corresponding salts thereof; Nα-(cyanoacetyl)-L-histidines, of the formula: and salts, tautomers and esters t... | 01/16/2007 |
| 7071358 | Arylsulfonamidobenzylic compounds Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases. ... | 07/04/2006 |
| 7026345 | Resolution of 3-amino alkylnitriles The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active β-amino alkylnitriles, and also to a process for preparing optically active β-amino alkylnitriles by resolving racemic β-amino alkylnitriles using chiral N-acetyl-alpha-am... | 04/11/2006 |
| 7026339 | Inhibitors of HCV NS5B polymerase The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions contai... | 04/11/2006 |
| 6951948 | Method for synthesis of substituted azole libraries The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) wherein X, R2 and the ring components ... | 10/04/2005 |
| 6936627 | Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use The invention describes novel nitrosated and/or nitrosylated H2 receptor antagonist compounds, and novel compositions comprising at least one H2 receptor antagonist compound that is optionally substituted with at least one NO and/or NO2 | 08/30/2005 |
| 6878829 | Method for producing β-alaninamides β-alaninamides of the general formula Wherein R1 is hydrogen or C1-6 alkyl which is unsubstituted or substituted with hyroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, unsubstituted o... | 04/12/2005 |
| 6720452 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therap... | 04/13/2004 |
| 6709824 | Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze ... | 03/23/2004 |
| 6703411 | Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them Benzoylguanidines of the formula (I) ##STR1## in which R1 to R4 have the meanings given in the specification and claims are suitable as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and for th... | 03/09/2004 |
| 6649643 | Imidazol-4-ylmehanols and their use as inhibitors of steroid C17-20 lyase Imidazol-4-ylmethanols and their uses for preventing and treating primary tumors, metastasis and recurrence of tumors, various symptoms accompanying tumors, prostatic hypertrophy, virilism, hirsutism, male pattern alopecia, precocious puberty, endometrios... | 11/18/2003 |
| 6638962 | Cycloheptene compounds Compound of formula (I): ##STR1## wherein: X represents a bond or alkylene, CO, S(O)n, --S(O)n --A1 --, --CO--A1 --, --A--S(O)n --A'1 -- or --A1 --CO--A'1 --, ... | 10/28/2003 |
| 6610716 | Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging Provided, among other things, is a compound of the formula: ##STR1##... | 08/26/2003 |
| 6593473 | Method of preparing granular N-alkyl-ammoniumacetonitrile salts Improved process for the preparation of granular N-alkylammoniumacetonitrile salts I R2 R3 N+ R1 --CR4 R5 --CN Y- (I) where R1 to R5 are hydrogen or organic radicals... | 07/15/2003 |
| 6562846 | Bisarylimidazolyl fatty acid amide hydrolase inhibitors The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain, particularly neuropathic pain, psychomotor disorder, hyper... | 05/13/2003 |
| 6525036 | Compounds and compositions as protease inhibitors The present invention relates to novel cysteine protease inhibitors of Formula I: ##STR1## the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.... | 02/25/2003 |
| 6518257 | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof To provide a composition having a steroid C17,20 -lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: ##STR1## wherein R i... | 02/11/2003 |
| 6495699 | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use The present invention is directed to compound of the formula I: ##STR1## wherein R1, R2, R3, R4, R5, X, Y, and ##STR2## are as defined herein. These compounds are useful for inhibiting the activity of... | 12/17/2002 |
| 6495580 | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.... | 12/17/2002 |
| 6407100 | Fungicidal aromatic oximes The invention relates to novel compounds of the formula ##STR1## in which R1 is C1-4 alkyl and (Y--X) is CH2, C1-2 alkylthio-CH.dbd. or C1-2 alkyl-ON.dbd. and Z is an aldimino or ketimino group, and t... | 06/18/2002 |
| 6384068 | Imidazole containing compounds having relatively low hydrogen content and relatively high nitrogen content and polymers and copolymers formed therefrom In one embodiment, the invention provides a polymer comprising imidazole ring units having nitrogen at the 1 and 3 positions of the ring; a carbon at each of the 2, 4 and 5 positions of the ring; and radical substituents G1 and G2 carried at the 4 and 5 p... | 05/07/2002 |
| 6358987 | Metalloproteinase inhibitors A compound of formula (I) ##STR1## wherein X is --COOH or --CONHOH Y is a group of formula (ID) or (IE) ##STR2## or a pharmaceutically acceptable salt, hydrate, or solvate thereof. The compounds are inhibitors of matrix metalloproteinases involved in tiss... | 03/19/2002 |
| 6359061 | Amide compound libraries Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds. ... | 03/19/2002 |
| 6326500 | Imidazole derivatives for blocking the release of arachidonic acid from phospholipids Compounds of formula (I) ##STR1## and salts thereof, wherein R1 is hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR13 R14, --N(R15)SO2 R16, haloalkoxy... | 12/04/2001 |
| 6323227 | Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides This invention relates to compounds of formula ##STR1## which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from conditions which can be ameliorated by t... | 11/27/2001 |
| 6310067 | Urocanic acid derivatives Urocanic acid derivatives useful as antiallergic agents represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R2 denotes hydrogen or lower alkyl, R3 denotes nitro, amino, cyano or C... | 10/30/2001 |
| 6303782 | Process for preparing benzylnitriles A process is described for preparing an aromatic compound substituted by a tertiary nitrile of Formula (1.0.0): ##STR1## comprising treating a substituted aromatic compound of Formula (2.0.0): ##STR2## with a secondary nitrile of Formula (3.0.0): ##S... | 10/16/2001 |
| 6297239 | Inhibitors of prenyl-protein transferase The present invention is directed to compounds which inhibit a prenyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 10/02/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6215001 | Imidazole derivatives as therapeutic agents Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof in which R1 represents hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR13 R14, --N(R15)SO | 04/10/2001 |
| 6197973 | Substituted 3-phenylpyrazoles 3-phenylpyrazoles of formula I ##STR1## wherein R1 is cyano, alkyl or haloalkyl; R2 is cyano or is optionally halogenated alkyl, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl; R3 is hydrogen, cyano, halogen, alkyl or haloal... | 03/06/2001 |
| 6184244 | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering infl... | 02/06/2001 |
| 6140508 | Process for making 1,5-disubstituted imidazoles The present invention is directed to a process for synthesizing 1,5-disubstituted imidazoles, which are useful in the preparation of farnesyl-protein transferase inhibitors.... | 10/31/2000 |
