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| Number | Title | Issue Date |
| 7728146 | Enzyme inhibitors There is disclosed herein compounds of formula (I), wherein: R1, R2, R3, R4 and R5 are defined throughout the description and the claims. The compounds of ... | 06/01/2010 |
| 7709657 | Process for the synthesis of organic compounds The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II): | 05/04/2010 |
| 7572921 | Substituted benzylimidazoles useful for the treatment of inflammatory diseases The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory conditions. ... | 08/11/2009 |
| 7560571 | Substituted pyrroles and imidazoles, compositions containing same, manufacturing process therefor and use thereof The disclosure concerns substituted imidazoles and pyrroles, compositions containing the same, the preparation thereof, and the use thereof as medicaments, particularly as anti-cancer agents. ... | 07/14/2009 |
| 7429575 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or i... | 09/30/2008 |
| 7354914 | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifica... | 04/08/2008 |
| 7326812 | Arylsulfonamidobenzylic compounds Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases. ... | 02/05/2008 |
| 7304086 | Inhibitors of glutaminyl cyclase The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophre... | 12/04/2007 |
| 7304049 | Succinoylaminobenzodiazepines as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 12/04/2007 |
| 7291641 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is selected from the various... | 11/06/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7220914 | Zwitterionic compounds and photovoltaic cells containing same Zwitterionic compounds, photovoltaic cell charge carrier layers containing such compounds, photovoltaic cells including such charge carrier layers, and related methods are disclosed. ... | 05/22/2007 |
| 7202383 | Compounds useful for modulating abnormal cell proliferation There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1... | 04/10/2007 |
| 7202263 | N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the following formula: where m, n, p, A1, R1, R2, R3 and R4 are described herein, as well as other N-heterocyclic derivatives, ... | 04/10/2007 |
| 7192975 | Arylimidazole derivatives, preparation and therapeutic used thereof Compounds of the formula wherein the substituents are as defined in the specification which are useful for the treatment of pain. ... | 03/20/2007 |
| 7192453 | Method of coloring keratin-containing fibres using diazonium salts The present invention relates to a method of coloring keratin-containing fibres, especially human hair, in which method a compound of formula (I), wherein R is hydroxy or NHR1, R1 being hydrogen or C1–C4alkyl, and B is a... | 03/20/2007 |
| 7183279 | Histogranin-like peptides and non-peptides, processes for their preparation and uses thereof The invention relates to new basic amino acid derivatives of general formulae I, II and III, and the preparation and use thereof in treatment of pain. The compounds have histogranin-like antinociceptive, morphine potentiating and COX-2 induction modulating activitie... | 02/27/2007 |
| 7169797 | Protein-tyrosine phosphatase inhibitors and uses thereof The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and... | 01/30/2007 |
| 7115646 | Cyclic diamines and derivatives as factor Xa inhibitors The present application describes cyclic diamino compounds, derivatives thereof, and pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa. ... | 10/03/2006 |
| 7094796 | Coupling product between tryptamine and an alpha-amino acid, process for its preparation as well as its application in the neurocosmetic field The purpose of the invention concerns a family of pseudodipeptides which are coupling products between tryptamine, an indole-primary amine, and a selection of alpha-amino acids, the said pseudodipeptides having the following general formula (I): | 08/22/2006 |
| 7090808 | Apparatus for testing sterilization methods and materials Apparatus and method for testing one or more sterilization indicators (e.g., biological indicators or chemical indicators) or other articles by contacting them under controlled sterilization conditions with a flowing antimicrobial gas containing hydrogen peroxide va... | 08/15/2006 |
| 7074786 | Histogranin-like peptides, processes for their preparation and uses thereof The invention relates to new basic amino acid derivatives of general formulae I, II and III, and the preparation and use thereof in treatment of pain. The compounds have histogranin-like antinociceptive, morphine potentiating and COX-2 induction modulating activitie... | 07/11/2006 |
| 7053084 | Succinoylamino benzodiazepines as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 05/30/2006 |
| 7030239 | Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases. ... | 04/18/2006 |
| 6989399 | Antiamyloid phenylsulfonamides: N-alkanol derivatives A series of N-alkanol-N-phenyl benzenesulfonamide and related derivatives of the Formula I are disclosed, wherein R1, R2, R3, X, and Y are defined herein. The compounds are inhibitors of... | 01/24/2006 |
| 6972287 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of the Formula (I) and a method of imaging amyloid deposits, as well... | 12/06/2005 |
| 6972299 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles This invention relates to a compound and the use of the compound of the formula wherein R1, R2, R3, R4 and R5 are as defined in the description, A signifies —CHâ... | 12/06/2005 |
| 6969728 | Modulators of TNF-α signaling The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas: | 11/29/2005 |
| 6965036 | Intermediates for guanidine mimics as factor Xa inhibitors The present application describes intermediates for nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D—E represent guanidine m... | 11/15/2005 |
| 6960600 | Azole or triazole derivatives, method for preparing the same and use thereof as antifungal medicaments The invention concerns novel azole or triazole derivatives of formula (I), wherein: X, Ar1, Ar3, A, R1, R5, R6, R7 and B are such as defined in the description, their preparation method and their use ... | 11/01/2005 |
| 6958329 | Lactams substituted by cyclic succinates as inhibitors of A-β protein production This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more spec... | 10/25/2005 |
| 6946460 | Azole or triazole derivatives, method for preparing same and use thereof as fungicides The invention concerns novel azole or triazole derivatives of formula (I), wherein X, Ar1, Ar2, Ar3, A, B, and R1 are as defined herein, their preparation method and their use as fungicides. | 09/20/2005 |
| 6936627 | Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use The invention describes novel nitrosated and/or nitrosylated H2 receptor antagonist compounds, and novel compositions comprising at least one H2 receptor antagonist compound that is optionally substituted with at least one NO and/or NO2 | 08/30/2005 |
| 6933390 | Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of fur... | 08/23/2005 |
| 6900161 | Azole or triazole derivatives, method for preparing same and use thereof as fungicides The invention concerns novel azole or triazole derivatives of formula (Ia) or (Ib), wherein: X, Ar1, Ar2, Ar3, A, B and R1 are such as defined in the description, the method for preparing same and their use as fungicides. ... | 05/31/2005 |
| 6887877 | Compounds and methods for the treatment or prevention of Flavivirus infections The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating Flaviviridae viral infection. ... | 05/03/2005 |
| 6884821 | Carboxylic acid derivatives and drugs containing the same Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydro... | 04/26/2005 |
| 6881754 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2 ... | 04/19/2005 |
| 6875884 | Urea derivatives as inhibitors for CCR-3 receptor Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thiourea derivatives can be synt... | 04/05/2005 |
| 6849634 | Potassium channel inhibitors Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described. ... | 02/01/2005 |
