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| Number | Title | Issue Date |
| 7304083 | 2-iminoimidazole derivatives (2) A 2-iminoimidazole derivative represented by the formula: {wherein R1, R2 and R3 represent hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents h... | 12/04/2007 |
| 7265135 | 2-oxy, 2-amino, and 2-thio-imidazole compounds The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compo... | 09/04/2007 |
| 7186742 | Benzamide inhibitors of the P2Xreceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1–R3 are as defined herein. The compounds of the invention are useful in the tr... | 03/06/2007 |
| 7109227 | Imidazolamino compounds The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds. ... | 09/19/2006 |
| 7049332 | HIV inhibiting N-aminoimidazole derivatives An N-aminoimidazole or N-aminoimidazolethione derivative, a pharmaceutically acceptable salt, a tautomer, an isomer, an ester or glycosylation product thereof, said derivative being represented by general formula (I): wherein m=zero or 1, n=zero or 1, R1 ... | 05/23/2006 |
| 6891068 | Water as promoter in the nucleophilic substitution of chloride Disclosed is a one step method for preparing a β-substituted sulfide by treating a β-halosulfide with a nucleophile in water. ... | 05/10/2005 |
| 6846838 | Ureido-substituted aniline compounds useful as serine protease inhibitors Compounds having the formula (I), or pharmaceutically-acceptable salts, hydrates or prodrugs thereof, are effective as inhibitors of Factor VIIa. ... | 01/25/2005 |
| 6797828 | Processes for the preparation of 4(5)-amino-5(4)-carboxamidoimidazoles and intermediates thereof The invention provides novel processes for preparing efficiently compounds of general formula (1) (wherein R1 and R2 are each independently hydrogen, optionally substituted C1-C10 alkyl, C3-C14 hydrocarbyl bearing alicyclic skeleton, or the like) and initermediates ... | 09/28/2004 |
| 6737433 | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them Imidazole derivatives of the formula: in which R1 and R2 are each independently hydrogen, (C1-C6)alkyl or (C3-C8)cycloalkyl; n is 0, 1 or 2;... | 05/18/2004 |
| 6677353 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 01/13/2004 |
| 6620963 | TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RAR RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY Compounds of the formula ##STR1## where the variables have the meaning defined in the specification, which bind specifically or selectively to to RAR retinoid receptors.... | 09/16/2003 |
| 6566387 | IL-8 receptor antagonists The invention relates to the use of guanidine compounds in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 05/20/2003 |
| 6479531 | Gastrin and cholecystokinin receptor ligands ##STR1## Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently .dbd.N--, --N(R5)--.dbd.CH--, --S-- or --O--. n is from 1 to 4; R1 is H ... | 11/12/2002 |
| 6458803 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 10/01/2002 |
| 6448286 | Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.... | 09/10/2002 |
| 6291499 | 2-cyclohexyl benzimidazole NMDA/NR2B antagonists Novel 4-substituted cyclohexanes substituted in the 1-position with 2-benzimidazoles, 2-imidazopyridines, or 4-imidazoles either directly or through a C1 -C4 alkyl, cycloalkyl, hydroxyalkyl, alkoxy or aminoalkyl chain are effective a... | 09/18/2001 |
| 6107345 | Benzocyclobutane compounds A compound of formula (I): ##STR1## wherein: Z1, Z2, Z3, Z4, which may be identical or different, represent a group as defined in the description, X represents oxygen, S(O)p, --(CH2)n | 08/22/2000 |
| 6075143 | Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids There are described N-ethylglycine derivatives of the formula I ##STR1## in which PG is a urethane-type or trityl-type amino protective group which is labile to weak acids, X is NH, O or S, Y is CH2, NH or O, and B' are bases customary in ... | 06/13/2000 |
| 6007865 | Reversing the formation of advanced glycosylation endproducts The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylatio... | 12/28/1999 |
| 5962487 | Antipicornaviral compounds and methods for their use and preparation Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating p... | 10/05/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5908931 | Preorganized hexadentate ligands useful in radiographic imaging agents The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for completing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.... | 06/01/1999 |
| 5631259 | Cycloalkltriols containing cyclic substituents, processes and intermediate products for their preparation and their use as antiviral and antiparasitic agents Cycloalkyltriols containing heterocyclic substituents, in particular cyclopentyl- and cyclohexyltriols containing heterocyclic substituents Compounds of the formulae I and II ##STR1## in which the substituents A, R1, R2 and R3 | 05/20/1997 |
| 5620831 | Cyanoguanidine derivatives, and thermosetting or photocurable, thermosetting resin composition using the same Disclosed are novel cyanoguanidine derivatives which are usable as an epoxy resin curing agent and are represented by the following general formula (1). A thermosetting resin composition and a photocurable and thermosetting resin composition containing th... | 04/15/1997 |
| 5604251 | Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their use Compounds of the formula (I) ##STR1## in which R1 is, for example, ethyl, R2 is, for example, ... | 02/18/1997 |
| 5541180 | [(benzodioxan, benzofuran or benzopyran) alkylamino] alkyl substituted guanidines The present invention is concerned with vasoconstricive [(benzodioxan, benzofuran or benzopyran)alkylamino]alkyl substituted guanidines having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemic... | 07/30/1996 |
| 5506263 | Benzyl derivatives and pesticides containing them Benzyl derivatives of the formula I ##STR1## where A is CH2, CHCl, CH-alkyl, CH-alkoxy, CH-alkylthio or N-alkoxy, B is OH, alkylthio, alkoxy or alkylamino, U, V, W are hydrogen, halogen, alkyl or alkoxy, D is ##STR2## where R' is hydrogen ... | 04/09/1996 |
| 5503776 | N-acylcarnosines and their use as antioxidants An N-acylamino acid compound represented by the general formula (1): R--CO--(NH--X--CO)n --OR1 (1) wherein (NH--X--CO) is an amino acid residue, X in (NX--X--CO) is variable with the kind of amino acid to be used, R--CO ... | 04/02/1996 |
| 5258381 | 2-substituted-2-imidazolines The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain novel 2-substituted-2-imidazolines. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting th... | 11/02/1993 |
| 5149872 | Process for the preparation of oxalyl- and oxamyl-hydrazides A new process for preparing oxalyl- and oxamyl-hydrazides which comprises contacting oxamide or diacetyloxamide with the corresponding hydrazine derivative of formula R1 R2 N--NHR3 wherein R1 represents a hydrogen at... | 09/22/1992 |
| 5130441 | Method for producing amino-2-imidazoline derivatives A method for producing an amino-2-imidazoline derivative comprises contacting an imidazoline sulfonic acid with at least one amine component in the presence of an alcohol-containing liquid medium at conditions effective to form the amino-2-imidazoline der... | 07/14/1992 |
| 5068365 | Hexahydrophthalic anilide derivatives Disclosed is novel hexahydrophthalic anilide derivatives and herbicide compositions comprising the derivatives. The hexahydrophthalic anilide derivatives of this invention are represented by the formula [I], [II] or [III]. ##STR1## (wherein R | 11/26/1991 |
| 5059598 | N-heterocyclo-substituted p-aminophenols Disclosed are compounds of the formula ##STR1## wherein: R1 is a lower alkyl group; R2 and R3 are each hydrogen or lower alkyl or R2 and R3 taken together may form --(CH2)4 -- or... | 10/22/1991 |
| 5059620 | Aryl substituted aminomethyl benzene derivatives The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole, pyrazole oxazole or thiazole; W is ... | 10/22/1991 |
| 5053504 | Process for benzazepine intermediates A process is disclosed for providing benzazepine intermediates of the formulae ##STR1## wherein R3, R4 and Y are as defined herein, which intermediates are useful in a process for the preparation of pharmaceutically useful ... | 10/01/1991 |
| 5017721 | Process for the preparation of oxalyl- and oxamyl-hydrazides A new process for preparing oxalyl- and oxamyl-hydrazides which comprises contacting oxamide or diacetyloxamide with the corresponding hydrazine derivative of formula R1 R2 N--NHR3 wherein R1 represents a hydrogen at... | 05/21/1991 |
| 4956470 | 1,3-disubstituted/imidazolium salts The imidazolium compounds of the formula ##STR1## wherein Q is arylene or heteroarylene, the group --NR1 R2 is a basic amino group, R3 is lower alkylthio, lower alkoxy or the group --(A)n --Ra, R4 | 09/11/1990 |
| 4908363 | Imidazole derivatives Imidazole derivatives of the formula ##STR1## wherein R1 and R2 each is lower alkyl, X is a residue of the formula ##STR2## R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R | 03/13/1990 |
| 4908446 | Inhibitors of nonenzymatic cross-linking The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts... | 03/13/1990 |
| 4880933 | Nitro- or cyano-derivatives of 2-imino-imidazolines and 2-imino-tetrahydropyrimidines Novel intermediates for insecticides of the formula (I) ##STR1## wherein Y represents nitro or cyano; A represents an ethylene or trimethylene radical, which is optionally substituted; and Z can have many possible meanings.... | 11/14/1989 |
