Class 548/328.5 - Nitrogen attached indirectly to the diazole ring by acyclic nonionic bonding

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which contain nitrogen attached indirectly to
No. of patents: 34
Last issue date: 12/07/2004

Number	Title	Issue Date
6828342	Nitric esters and nitrate salts of specific drugs The present invention relates to nitric acid salts with medicines active in the respiratory system pathology treatment. ...	12/07/2004
6645991	଱v댣 integrin inhibitors The invention describes novel compounds of the formula I which are biologically active as ligands of integrin ଱vଲ.sub.3 in which X, Y, Z, R1, R2, R4 and R5 are as defined in claim 1, and their ...	11/11/2003
6465650	Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids The invention provides a processes for the preparation of a compound of Formula I, or a salt thereof ##STR1## wherein PG is a urethane- or trityl-type protective group; X is NH, O, or S; Y is CH2, O, or NH; and B' is a base customary in nucleot...	10/15/2002
6335451	Five-membered heterocycles having biphenylsulfonyl substitution, with sulfonylcyanamide side chain, compositions containing them, and methods of using them Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the formula I ##STR1## in which the symbols have the meanings indicated i...	01/01/2002
6191157	Hetero-linked phenylglycinolamides The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments....	02/20/2001
6075143	Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids There are described N-ethylglycine derivatives of the formula I ##STR1## in which PG is a urethane-type or trityl-type amino protective group which is labile to weak acids, X is NH, O or S, Y is CH2, NH or O, and B' are bases customary in ...	06/13/2000
5932598	Prodrugs of benzenesulfonamide-containing COX-2 inhibitors Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders....	08/03/1999
5733882	Retroviral protease inhibitors The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating diseases related to infection by retroviruses....	03/31/1998
5691371	Nitrobenzyl mustard quaternary salts and their use as hypoxia-selective cytotoxic agents Nitrobenzyl mustard quaternary salts of formula (I), ##STR1## and the pharmaceutically acceptable salts thereof, process for their manufacture and their chemotherapeutic use as hypoxia selective cytotoxic agents. Wherein, X represents a linker chain ...	11/25/1997
5312828	Substituted imidazoles having angiotensin II receptor blocking activity Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m...	05/17/1994
5273991	Imidazole-containing compositions and methods of use thereof analogs of distamycin The present invention relates to oligopeptide derivatives that are conjugated to DNA alkylating agents, having the formula ##STR1## wherein m is 0 to 4; n is 2 to 4; each R1 is the same or different and is hydrogen or C1 -C...	12/28/1993
5248689	Substituted N-(imidazolyl)alkyl alanine derivatives Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m...	09/28/1993
5234917	Substituted 5-(alkyl)carboxamide imidazoles Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma pharmaceutical compositions including these antagonists, and me...	08/10/1993
5196541	Process for the preparation of substituted 3-aminoacrylic esters There is described a new process for the preparation of substituted 3-aminoacrylic esters of the general formula (I) ##STR1## in which R1, R2, R3, R4, X and n have the meaning given in the description. The ...	03/23/1993
5190942	Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives Novel compounds are disclosed having the formula ##STR1## wherein X, Y, R1, R2, R3, R4, and R5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefor...	03/02/1993
5098921	Nitro-substituted aromatic or hetero-aromatic compounds for use in cancer treatment A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with...	03/24/1992
4995898	Imidazole compounds and biocidal composition comprising the same for controlling harmful organisms Novel imidazole compounds are disclosed, which are represented by the following general formula: ##STR1## wherein: R1 represents a cyano group or a --CSNHR5 group, wherein R5 represents a hydrogen atom, a C1-4	02/26/1991
4916129	Combination ଲ-blocking/angiotensin II blocking antihypertensives Imidazole compounds such as ##STR1## which have angiotensin II antagonizing properties as well as ଲ-adrenoceptor antagonizing properties are useful as antihypertensives and for treatment of congestive heart failure....	04/10/1990
4851423	Pharmaceutically active compounds The disclosed invention is compounds represented by the formula and pharmaceutically acceptable acid addition salts and quarternary amine salts thereof, wherein Z is phenyl, naphthyl or adamantyl; substituted phenyl wherein the substituents are one or more of ...	07/25/1989
4826990	2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents There are disclosed compounds of the formula ##STR1## wherein X is ##STR2## Y is ##STR3## Z is ##STR4## R1 is ##STR5## n is 0-5; R2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, t...	05/02/1989
4678799	1,2(1,4)-dimethyl-4(2)-(2-hydroxyethyl)-5-nitro-imidazole antiprotozoal agents with reduced mutagenicity A group of 4-substituted-5-nitroimidazoles is described, having effective antiprotozoal activity with much less mutagenicity than is shown by known 5-nitroimidazoles....	07/07/1987
4631289	Useful in radiotherapy of chemotherapy 4-aziridino-1-nitroimidazol-1-yl-2,3-butanediols A compound of formula I ##STR1## in which formula: R1 represents hydrogen or an alkyl group; R2 -R5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; and n is 2. The compounds are used as a radiation sensitizing ag...	12/23/1986
4596817	Imidazole compounds useful in radiotherapy or chemotherapy and compositions A chemopotentiating or radiation sensitizing compound of formula I ##STR1## in which formula: R1 represents hydrogen or an alkyl group; R2 -R5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; and n is 1 or 2 and p...	06/24/1986
4581368	Aziridino containing nitro imidazoles and pharmaceutical compositions A compound of formula I ##STR1## in which formula: R1 represents hydrogen or an alkyl group; R2 -R5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; and n is 1....	04/08/1986
4482722	Ester of metronidazole with N,N-dimethylglycine and acid addition salt thereof N,N-dimethylglycine ester of metronidazole, acid addition salt thereof and method of preparing such ester or acid addition salt. The novel compounds exhibit favorable solubility in water and are especially useful for the parenteral treatment of certain an...	11/13/1984
4463012	Nitroimidazoles having trichomonacidal activity and pharmaceutical compositions thereof The nitroimidazoles having general formula: ##STR1## wherein R represents alkyl C1 -C5, hydroxyalkyl C1 -C5, an alkylsulfonyl group, an aminoalkyl group, wherein the alkyl contains 1 to 5 carbon atoms and t...	07/31/1984
4323689	2-Hydroxypropylimidazoles, their preparation, and their use as oil-soluble corrosion inhibitors Novel 2-hydroxypropylimidazole derivatives of the formula I ##STR1## where m is 1 or 2 and n is 0 or 1, R1 is an aliphatic or cycloaliphatic radical of 6 to 21 carbon atoms, R, if n is O, is an aliphatic, cycloaliphatic, aromatic or aralip...	04/06/1982
4310675	Monoradioiodinated imidazole derivatives Monoradioiodinated derivatives of compounds employed in a radioassay prepared from precursors which are either active esters, amino acids, or amines, including a phenolic of imidazole substituent group in which one of the possible two sites on the group f...	01/12/1982
4232165	2-Substituted-1-alkyl-nitroimidazoles Novel 2-substituted 1-alkyl-nitroimidazoles and a process for their preparation by reaction of 2-methyl-nitroimidazoles with oxalic acid diesters, followed by reaction of the resulting nitroimidazol-2-yl-pyruvic acid esters with chlorine, in turn followed...	11/04/1980
4067989	1,3-Diazole heterocyclic compounds and their use as pesticides Plant fungicidal compounds of formula: ##STR1## WHEREIN R3 is alkyl, furyl, thienyl or phenyl, R4 is hydrogen, halogen, nitro, phenyl, alkoxy or alkyl, n is 1, 2 or 3, and Z is C=O or a derivative thereof; and their salts....	01/10/1978
4038410	Nitroimidazole derivatives and process for the preparation thereof Nitroimidazoles of the formula ##STR1## wherein R is dialkylaminoacryloyl; 3-, 4-, or 5-pyrazolyl or a mixture thereof which is unsubstituted or substituted by alkyl or, at the 1-position, by hydroxyalkyl or a nitro ester thereof, acyloxyalkyl, nitro...	07/26/1977
3962274	1-Azidoalkylimidazoles Preparation and the antimicrobial and antihypertensive properties of 1-azidoalkylimidazoles and their salts are disclosed....	06/08/1976
3952007	Processes for preparing 5-nitro-1-methyl-2-(2-dialkylaminovinyl)-imidazole and 5-nitro-1-methyl-2-imidazolyl carboxaldehyde 1-SUBSTITUTED 5-NITRO-2-(2-DIALKYLAMINOVINYL)-IMIDAZOLES HAVING TRICHOMONACIDAL ACTIVITY OF THE FORMULA: ##SPC1## Wherein R is H, CH3 or C2 H5 and X is hydrocarbon or hydrocarbon substituted with a halogen or a hydroxy, et...	04/20/1976
3933803	New beta-aminoketone derivatives The invention relates to compounds of the formula: ##EQU1## wherein Ar is a substituted or unsubstituted aryl group, --N(R1 R2) is a generic primary or secondary amine, X is O or a functional derivative of the C = O group, and ...	01/20/1976

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Class 548/328.5 - Nitrogen attached indirectly to the diazole ring by acyclic nonionic bonding