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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 8168802 | Ring closing and related methods and intermediates Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula: ... | 05/01/2012 |
| 7951958 | Imidazole compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inh... | 05/31/2011 |
| 7795447 | Imidazole compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inh... | 09/14/2010 |
| 7737284 | Synthesis of temozolomide and analogs This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process. ... | 06/15/2010 |
| 7709656 | Ionic liquids containing guanidinium cations The present invention relates to salts having guanidinium cations, to processes for the preparation thereof, and to the use thereof as ionic liquids. ... | 05/04/2010 |
| 7446209 | Synthesis of temozolomide and analogs This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process. ... | 11/04/2008 |
| 7368572 | Acetylene derivatives as inhibitors of histone deacetylase The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparin... | 05/06/2008 |
| 7342118 | Imidazole compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inh... | 03/11/2008 |
| 7326705 | Heterocyclic sodium/proton exchange inhibitors and method Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, al... | 02/05/2008 |
| 7317024 | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The invention relates to a class of novel non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have th... | 01/08/2008 |
| 7312359 | Tetralin and indane derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods f... | 12/25/2007 |
| 7304083 | 2-iminoimidazole derivatives (2) A 2-iminoimidazole derivative represented by the formula: {wherein R1, R2 and R3 represent hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents h... | 12/04/2007 |
| 7304070 | Aadenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract di... | 12/04/2007 |
| 7285565 | Benzamides and related inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 10/23/2007 |
| 7244725 | Acetyl 2-hydroxy-1, 3-diaminoalkanes Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and RC are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase en... | 07/17/2007 |
| 7087751 | Synthesis of temozolomide and analogs This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process. ... | 08/08/2006 |
| 7078529 | Imidazole derivatives The invention provides compounds of formula 1 wherein R1, R2, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicat... | 07/18/2006 |
| 7074923 | Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to sy... | 07/11/2006 |
| 7041670 | Florfenicol-type antibiotics The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such... | 05/09/2006 |
| 6992097 | Growth hormone secretagogues This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in thes... | 01/31/2006 |
| 6949578 | Cycloalkyl alkanoic acids as integrin receptor antagonists The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of select... | 09/27/2005 |
| 6933390 | Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of fur... | 08/23/2005 |
| 6927290 | Production of mixed acid anhydride and amide compound There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p (1) wherein R1, R2 and Y denote the same as defined below, n and p ... | 08/09/2005 |
| 6911595 | Charge transfer material, and photoelectric conversion device and photoelectric cell using same, and pyridine compound A charge transfer material comprising a basic compound having negative charge and represented by the following general formula (I): (A1-L)n1-A2·M (I), wherein A1 represents a group having negativ... | 06/28/2005 |
| 6849735 | Methods of synthesis for 9-substituted hypoxanthine derivatives An improved method of synthesis of a 9-substituted hypoxanthine derivative comprises the steps of: (1) reacting aminocyanacetamide with triethyl orthoformate to form an imidoester derivative of aminocyanacetamide; (2) forming a compound having a reactive amino group... | 02/01/2005 |
| 6844434 | Synthesis of temozolomide and analogs This invention relates to a novel process for the synthesis of temozolomide, an antitumor compound, and to intermediates useful in this novel process. ... | 01/18/2005 |
| 6828331 | Growth hormone secretagogues What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C6H5CH2OCH2—, C6H5 (CH2... | 12/07/2004 |
| 6818775 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity. ... | 11/16/2004 |
| 6667310 | Substituted guanidine derivatives The present application provides guanidine derivatives of the formula (I) ##STR1## wherein R1, R2, R3, A and Z are as defined herein.... | 12/23/2003 |
| 6653321 | Naphthylsulfonic acids and related compounds as glucose uptake agonists Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptabl... | 11/25/2003 |
| 6653483 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 11/25/2003 |
| 6649613 | Diacylhydrazine derivatives Diacylhydrazine derivatives of general formula (I) ##STR1## wherein X, Y, Z, R1, 2 and R3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to co... | 11/18/2003 |
| 6635630 | Selective neurokinin antagonists Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is --O--, --S--, --SO--, ... | 10/21/2003 |
| 6479531 | Gastrin and cholecystokinin receptor ligands ##STR1## Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently .dbd.N--, --N(R5)--.dbd.CH--, --S-- or --O--. n is from 1 to 4; R1 is H ... | 11/12/2002 |
| 6465650 | Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids The invention provides a processes for the preparation of a compound of Formula I, or a salt thereof ##STR1## wherein PG is a urethane- or trityl-type protective group; X is NH, O, or S; Y is CH2, O, or NH; and B' is a base customary in nucleot... | 10/15/2002 |
| 6448286 | Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.... | 09/10/2002 |
| 6395764 | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agnonists This invention involves compounds having the following structure: ##STR1## wherein: a) R1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R2 and R3 are each independently selected from hydrogen; unsubstituted C... | 05/28/2002 |
| 6310070 | Purine derivatives and medicinal use thereof A novel purine derivative exhibiting an effect to control inflammatory symptoms characteristic to nephritis and a medicine comprising this compound as an effective ingredient are provided. The compound is represented by the following general formula (I), ... | 10/30/2001 |
| 6268313 | Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production The dihalopropene compounds of the general formula [I] have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.... | 07/31/2001 |
| 6118001 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNF-mediated diseases, including degenerative diseases and certain cancers.... | 09/12/2000 |
