Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7442760 | Electroactive polymers Electroactive polymeric arylenes and intermediates useful for making such polymers are disclosed. The present invention also provides electroactive compositions comprising the electroactive polymeric arylenes, organic electronic devices which comprise these polymers... | 10/28/2008 |
| 7407974 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thro... | 08/05/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7326726 | Biaryl substituted triazoles as sodium channel blockers Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, eit... | 02/05/2008 |
| 7271406 | Electron transport agents for organic electronic devices Compounds and compositions are provided that can be used as electron transport agents in organic electronic devices such as organic electroluminescent devices. The compounds are non-polymeric and have an aromatic core conjugated to end capping groups. The aromatic c... | 09/18/2007 |
| 7230010 | 1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: where... | 06/12/2007 |
| 7179802 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: are selective inhibitors of the 11β-HSD1 enzyme. The compounds are useful for the treatment of diabetes, su... | 02/20/2007 |
| 7172633 | Lightening dye composition comprising at least one cationic direct dye containing mixed chromophores The present invention relates to a lightening dye composition comprising, in a suitable dyeing medium, an oxidizing agent, an alkaline agent in an amount such that the pH of the composition is greater than 7, and a mixed cationic dye comprising several chromophores ... | 02/06/2007 |
| 7125725 | Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration A novel achiral biaryl-type compound and a circular dichroism(CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chir... | 10/24/2006 |
| 7109243 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present inven... | 09/19/2006 |
| 7101932 | Method for the preparation of 1-benzotriazolyl carbonate esters of poly (ethylene glycol) The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an ami... | 09/05/2006 |
| 7094902 | Electroactive polymers Electroactive polymeric arylenes and intermediates useful for making such polymers are disclosed. The present invention also provides electroactive compositions comprising the electroactive polymeric arylenes, organic electronic devices which comprise these polymers... | 08/22/2006 |
| 7074815 | 4-[3,5-bis-(2-hydroxy-phenyl)-[1,2,4]triazol-1-yl]-benzoic acid derivatives for treating an excess of metal in the body The present invention provides new 4-[3,5-bis-(2-hydroxy-phenyl)-[1,2,4]triazol-1-yl]-benzoic acid derivatives which can be used in the treatment of diseases which cause an excess of metal in the human or animal body or are caused by it. | 07/11/2006 |
| 7037930 | 3-arylphenyl sulfide derivative and insecticide and miticide 3-Arylphenyl sulfide derivatives represented by general formula (I): (wherein R is a C2-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 ... | 05/02/2006 |
| 7019144 | 1,2,4-Triazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 1,2,4-Triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided. ... | 03/28/2006 |
| RE38962 | Diphenyl-triazole derivatives and their use as anti-gestative immuno-suppressant and anti-tumoral agents Compounds of formula (I), wherein X and Y are independently carbon or nitrogen but not both simultaneously carbon, R1 is a group (II) and R2 is a group (III), R5 being a carbonate, carbamate or phosphate residue, are useful as anti-g... | 01/31/2006 |
| 6967251 | Reagents for labeling biomolecules having aldehyde or ketone moieties Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. In one embodiment is provided reagents that have the following formula: | 11/22/2005 |
| 6849636 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli... | 02/01/2005 |
| 6849652 | 1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: | 02/01/2005 |
| 6844444 | 1H-1,2,4-triazole-5-yl-acetic ester compound There is disclosed a 1H-pyrrole-[1,2-b][1,2,4]triazole compound represented by formula (I): wherein R is an alkyl group; R1, R2, R3, R1′, R2′, and R3 | 01/18/2005 |
| 6812241 | Nitrogen-containing heterocycles having parasiticidal properties Compounds of formula (I) wherein the substituents are as defined herein, are antiparasitic agents. ... | 11/02/2004 |
| 6730690 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: are selective inhibitors of the 11β-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as no... | 05/04/2004 |
| 6727098 | Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chi... | 04/27/2004 |
| 6723742 | Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R1-R5 are as defined in the description. The compounds have useful pharmaceutical properties and are particularly activ... | 04/20/2004 |
| 6696475 | Substituted phenyl derivatives, their preparation and use The present invention discloses compounds having the formula ##STR1## wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.... | 02/24/2004 |
| 6610723 | Imidazole derivatives Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which makes them key players i... | 08/26/2003 |
| 6608093 | Pesticidal 1-polyarylpyrazoles A compound of formula (I): ##STR1## compositions containing them and methods of use to control pests.... | 08/19/2003 |
| 6566383 | Sulfonyltriazol derivatives and their use for combating micro-organisms Sulphonyltriazoles of the formula ##STR1## wherein Hal, R1, R2 are as defined in the specification are provided along with a process for preparing these compounds and a process using these compounds to control the growth of microorga... | 05/20/2003 |
| 6495604 | Cycloalkene derivatives, process for producing the same, and use The present invention provides a compound represented by the formula: ##STR1## wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionall... | 12/17/2002 |
| 6492525 | Organometallic complexes comprising cationic heterocyclic carbenes The invention concerns novel organometallic complexes comprising cationic heterocyclic carbenes. It also concerns a method for preparing said complexes from dicationic heterocyclic precursor compounds. It further concerns the use as catalysts of said orga... | 12/10/2002 |
| 6465504 | Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I ##STR1## in which R1 -R5 are as defined in the description. The compounds have useful pharmaceutical properties and are particularly active as iron chelators. They... | 10/15/2002 |
| 6380258 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroa... | 04/30/2002 |
| 6362342 | Triazole compounds and methods of making same The present invention relates to novel triazole compounds of the following formula: ##STR1## wherein R1 to R5 have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such ... | 03/26/2002 |
| 6342513 | Oxazolidinone antibacterial agents having a thiocarbonyl functionality The present invention provides compounds of Formula 1: ##STR1## or pharmaceutical acceptable salts thereof wherein A, G and R1 are as defined in the claims which are antibacterial agents.... | 01/29/2002 |
| 6333343 | Diphenyl-triazole derivatives and their use as anti-gestative, immuno-suppressant and anti-tumoral agents Compounds of formula (I), wherein X and Y are independently carbon or nitrogen but not both simultaneously carbon, R1 is a group (II) and R2 is a group (III), R5 being a carbonate, carbamate or phosphate residue, are usefu... | 12/25/2001 |
| 6297261 | Substituted phenyl derivatives, their preparation and use A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia. ##STR1##... | 10/02/2001 |
| 6262099 | 3-(substituted phenyl)-5-(substituted cyclopropyl)-1,2,4-triazole compounds 3-(Substituted phenyl)-5-(substituted cyclopropyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of ... | 07/17/2001 |
| 6083965 | N-aryl-1,2,3-triazole compounds for pharmaceutical and veterinary application Compounds of formula (I): ##STR1## wherein the substituents are as defined herein, are antiparasitic agents.... | 07/04/2000 |
| 6077813 | Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides of the general formula (I) ##STR1## , wherein Z, R1, R2 and R3 are as defined by the specification, which are useful herbicidal agents.... | 06/20/2000 |
| 6004903 | 2-Anylocyclohexanediones having improved herbicidal properties Benzoyl derivatives of the formula I ##STR1## where Z is a 5-membered or 6-membered heterocyclic, saturated or unsaturated radical containing one to three hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen, Q is a cyclohex... | 12/21/1999 |
