Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 7777049 | Crystalline forms of Rizatriptan benzoate The present invention is directed to the novel polymorphic Form A and Form B of Rizatriptan benzoate, processes for the preparation thereof and pharmaceutical compositions comprising these crystalline forms. ... | 08/17/2010 |
| 7279581 | Process for preparing a pharmaceutically active compound In particular, rizatriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of aniline hydrochloride (II); followed by reduction and acidification to give the hydrazine (III); b) reaction in situ of the hydrazine hyd... | 10/09/2007 |
| 7208512 | Benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma The present invention provides benzodifuran imidazoline derivatives and benzofuran imidazoline derivatives for lowering intraocular pressure and providing ocular neuroprotection. ... | 04/24/2007 |
| 7148249 | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, ... | 12/12/2006 |
| 6964977 | Oxindole derivatives The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alt... | 11/15/2005 |
| 6946562 | Synthesis of peptoid substituted azole compounds Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product fro... | 09/20/2005 |
| 6911463 | 3-substituted oxindole β-3 agonists The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity. ... | 06/28/2005 |
| 6897231 | Indazole derivatives as JNK inhibitors and compositions and methods related thereto Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R1, R2 and A are as defined... | 05/24/2005 |
| 6875770 | Indole derivative having heterocycle and mono- or diazaindole derivative There is provided a compound represented by the general formula (1): wherein Het represents an optional substituted heterocylic group A1 and A2 each independently represent —CH═, etc.; A3... | 04/05/2005 |
| 6849636 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli... | 02/01/2005 |
| 6777418 | Retinoid compounds (I) The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and... | 08/17/2004 |
| 6743817 | Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists... | 06/01/2004 |
| 6713473 | Tricyclic compounds A compound represented by the formula (I) [A represents a 5- to 7-membered hydrocarbon ring group; L represents —NR3—CO—, —CO—NR3— and the like (R3 represents a hydrogen atom, a lower alkyl group, a lower acyl group and t... | 03/30/2004 |
| 6713498 | Method for treating glaucoma VI Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the formula I: ... | 03/30/2004 |
| 6673797 | Heterocyclic indole derivatives and mono- or diazaindole derivatives There is provided a compound represented by the ##STR1## general formula (1): wherein Het represents an optionally substituted heterocyclic group; A1 and A2 each independently represent --CH.dbd., etc.; A3 represents -... | 01/06/2004 |
| 6610737 | Non-psychotropic cannabinoids Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereosp... | 08/26/2003 |
| 6555559 | 5,6,7-trinor-4,8-inter-m-phenylene PGI2, derivative and drugs containing the same The present invention provides novel PGI2 derivatives and an anti Helicobacter agent, a platelet function potentiating agent or a cervical ripening agent containing any of the derivatives.... | 04/29/2003 |
| 6541499 | Antithrombotic agents The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the ... | 04/01/2003 |
| 6391902 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers Compounds of the Formulae (I) and (II): ##STR1## wherein R1, R2, R3, X, Y and Z are as defined in the specification which compounds are useful in the treatment of disorders associated with smooth muscle contraction via pot... | 05/21/2002 |
| 6352959 | Thiochromanoylpyrazolone derivatives Thiochromanoylpyrazolone derivatives of the formula I ##STR1## where: A is an unsubstituted or substituted, saturated or unsaturated alkyl chain; R1 is cyano, thiocyanato, nitro, OR4, SR5, SOR6, S02 R... | 03/05/2002 |
| 6306852 | Indole derivatives useful as endothelin receptor antagonists ##STR1## Compounds of formula (I), and their pharmaceutically acceptable derivatives, wherein R1 and R2 are optional substituents and independently represent C1-6 alkyl, C2-6 alkenyl, optionally substituted by C... | 10/23/2001 |
| 6294561 | Cyclic AMP-specific phosphodiesterase inhibitors Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as ce... | 09/25/2001 |
| 6288099 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers Compounds of the Formulae (I) and (II): ##STR1## wherein R1, R2, R3, X, Y and Z are as defined in the specification which compounds are useful in the treatment of disorders associated with smooth muscle contraction via pot... | 09/11/2001 |
| 6271241 | Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein X, R1, R2, R3, R4, R5, R6, R7, A, B, C, and D are variables de... | 08/07/2001 |
| 6248768 | Benzimidazole derivatives and pharmacologically acceptable salts thereof This invention provides a compound having both IL-4 production inhibitory activity and PDE (IV) inhibitory activity, represented by formula (I): ##STR1## and a pharmaceutical composition or a therapeutic agent for acute and chronic inflammatory diseases a... | 06/19/2001 |
| 6211219 | Aminocyclohexane derivatives as 5-HT receptor agonists A class of substituted aminocyclohexane derivatives are selective agonists of 5-HT1 -like receptors, being potent agonists of the human 5-HT1D.sub. receptor subtype while possessing at least a 10-fold selective aff... | 04/03/2001 |
| 6166057 | Fungicides for the control of take-all disease of plants A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1## wherein Z1 and Z2 are C or N and are part of an aromatic ring selected from benzene, p... | 12/26/2000 |
| 6140347 | Azetidine, pyrrolidine and piperidine derivatives as 5-HT receptor agonists A class of compounds of formula (I) wherein Z, E, Q, T, U, V, W, M, R1, R7 and R8 are as defined herein; are selective agonists of 5-HT1 -like receptors, being potent agonists of the human 5-HT1D | 10/31/2000 |
| 6051591 | Diazabicyclooctane derivatives A class of 2,7-diazabicyclo[3.3.0]octane derivatives represented by formula I are selective agonists of the 5-HT1D receptor. The compounds are useful in the treatment of migraine and related conditions.... | 04/18/2000 |
| 6051572 | Azetidine, pyrrolidine and piperidine derivatives A class of azetidine, pyrrolidine and piperidine derivatives, substituted by inter alia a phenylmorpholinyl, phenylpiperidinyl or benzimidazolone moiety, are selective agonists of 5-HT1 -like receptors, being potent agonists of the human 5-HT | 04/18/2000 |
| 6046205 | Indole and indazole compounds Compound of formula (I): ##STR1## wherein: n is 0 or 1, A represents a ς bond or alkylene or alkenylene, X represents nitrogen or C--R2, R1 represents hydrogen or alkyl, G1 represents any one of the groups defined in the descr... | 04/04/2000 |
| 6040327 | Benzimidazole, benzoxazole and benzothiazole compounds A compound of formula (I): ##STR1## wherein: R1 represents halogen or a different group as defined in the description, Ra and Rb, which mnay be identical or different, represent hydrogen, alkyl, or hydroxy, X represents oxygen or sulphur o... | 03/21/2000 |
| 6020336 | Indole and indazole compounds Compound of formula (I): ##STR1## wherein: n is 0 or 1, A represents a ς bond or alkylene or alkenylene, X represents nitrogen or C--R2, R1 represents hydrogen or alkyl, and G1 represents any one of the groups defined in the d... | 02/01/2000 |
| 6008219 | Bicyclic amine derivatives and their use as anti-psychotic agents This invention relates to compounds of formula (I) ##STR1## which are useful as modulators of D3 receptors, in particular as antipsychotic agents.... | 12/28/1999 |
| 5985901 | Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both m... | 11/16/1999 |
| 5962436 | Fungicidal cyclic amides Cyclic amides, including triazole containing cyclic amides, their N-oxides, agriculturally-suitable salts and compositions, and their methods of use as fungicides.... | 10/05/1999 |
| 5902819 | Triazole derivatives Triazole derivatives represented by formula (IIA), and salts and prodrug thereof, wherein R1 represents C1-6 alkoxy(C1-6)alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C3-7 ... | 05/11/1999 |
| 5869508 | 1,2,3-Benzothiadiazole derivatives Novel 1,2,3-benzothiadiazole derivatives of the formula ##STR1## in which Het has the meanings set forth in the specification, and addition products thereof with an acid or metal salt are very effective for the control of undesired microorganisms. Novel i... | 02/09/1999 |
| 5837702 | 4-arylamino-benzopyran and related compounds Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH2 --, --C(O)--, --O--, --S-- or --N(R8)-- where R8 is hydrogen, alkyl, haloalkyl, aryl, a... | 11/17/1998 |
| 5834502 | Triazolylmethyl-indole ethylamine bisulfate salt The bisulfate salt of N,N-dimethyl-2-5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl!ethylamine is a selective agonist of 5-HT1 -like receptors and is useful in the treatment of migraine and associated disorders.... | 11/10/1998 |
