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| Number | Title | Issue Date |
| 7989637 | Triazole-substituted arylamides as P2Xand P2Xantagonists Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted triazolyl, and R2, R3, R4, R5, R6, R7 | 08/02/2011 |
| 7407972 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thro... | 08/05/2008 |
| 7390827 | 3-aminocarbonyl substituted benzoylpyrazolones A description is given of derivatives of benzoylpyrazoles of the formula (I) and of their use as herbicides. In this formula (I) R1a, R1b, R1c, R2, R3, R4 and ... | 06/24/2008 |
| 7378433 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-... | 05/27/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7317031 | Substituted triazole diamine derivatives as kinase inhibitors The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder. ... | 01/08/2008 |
| 7303590 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof Bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms. This invention further relates to a composition for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and one or more bicyclic fused 5-5 heteroaro... | 12/04/2007 |
| 7253169 | Aza compounds, pharmaceutical compositions and methods of use The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. ... | 08/07/2007 |
| 7229480 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof Bicyclic 5-5 heteroaromatic compounds having a ring junction nitrogen and incorporating thia or oxa heteroatoms heteroatoms. Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and one or more bicyclic 5-5 heteroaromatic ... | 06/12/2007 |
| 7230023 | Water-soluble triazole fungicide A triazole compound of the formula (I) or a pharmacologically salt thereof: wherein X represents a group of formula X—OH which has antifungal activity, L represents an -(adjacently substituted C6-C | 06/12/2007 |
| 7226939 | Thienopyridine analogues with antifungal activity and process thereof The invention relates to novel antifungal compounds and its pharmaceutically acceptable salts, having as part of its structure, imidazolyl or benzimidazolyl derivatives. The imidazolyl derivative may be substituted at 2 position from among the group consisting of ar... | 06/05/2007 |
| RE39663 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitrogen heteroc... | 05/29/2007 |
| 7205312 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydrox... | 04/17/2007 |
| 7205323 | Dipeptidyl peptidase IV inhibitors pharmaceutical compositions containing them, and process for their preparation The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: wherein X, Y, a, R1, and R2 are as defined herein. ... | 04/17/2007 |
| 7132437 | Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs are conjugates formed from two components, namely, a first component... | 11/07/2006 |
| 7129361 | Thienylazolylalkoxyethanamines, their preparation and their application as medicaments The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-... | 10/31/2006 |
| 7119209 | Process for preparing indolinone derivatives The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process. ... | 10/10/2006 |
| 7056940 | Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-2-yl]-1,2,4-triazoles Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, 5′-arylthien-2-yl group in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests. ... | 06/06/2006 |
| 7026428 | Blocked polyisocyanates The invention relates to aqueous and/or water-dilutable blocked polyisocyanates, their preparation and use in optionally self-crosslinking one-component systems. ... | 04/11/2006 |
| 6949576 | Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-3-yl]-1,2,4-triazoles Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, 5′-arylthien-3-yl group in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests. ... | 09/27/2005 |
| 6924302 | Substituted triazole diamine derivatives as kinase inhibitors The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder. ... | 08/02/2005 |
| 6894173 | Intermediates useful for synthesis of heteroaryl-substituted urea compounds, and processes of making same Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic co... | 05/17/2005 |
| 6884892 | Production methods of epoxytriazole derivative and intermediate therefor An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with ... | 04/26/2005 |
| 6849636 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli... | 02/01/2005 |
| 6833375 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C | 12/21/2004 |
| 6787620 | Homobimetallic and heterobimetallic alkylidene complexes of ruthenium containing N-heterocyclic carbene ligands The invention relates to complexes of ruthenium of the structural formula I where X is an anionic ligand, Z is a monodentate to tridentate ligand which contains a metal and is nonionically bound to the ruth... | 09/07/2004 |
| 6784195 | Pyrazole compositions useful as inhibitors of ERK Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1, R2, T and Ht are described in the specification. The compounds are useful for treating disea... | 08/31/2004 |
| 6770665 | Insecticial 3-(2,6-disubstituted phenyl)-5-[4- or 5-arylthien-2- or -3-yl]-1,2,4-triazoles Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, arylthien-2- or -3-yl in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests. ... | 08/03/2004 |
| 6552051 | Energetic nitramine-linked azoles and related compounds as oxidizers, initiators and gas generators Novel compounds are provided having the structural formula R[--N(NO2)--L--R1 ]n wherein R, L, R1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high ... | 04/22/2003 |
| 6552139 | Process for preparing acyclic olefins using homobimetallic and heterobimetallic alkylidene complexes of ruthenium containing N-heterocyclic carbene ligands The invention relates to complexes of ruthenium of the structural formula I ##STR1## where X is an anionic ligand, Z is a monodentate to tridentate ligand which contains a metal and is nonionically bound to the ruthenium center, R1 and R2... | 04/22/2003 |
| 6500950 | Benzylidenepyrazolones, their preparation and use Benzylidenepyrazolones of the formula I, ##STR1## where the substituents and the index n have the following meanings: R1 is unsubstituted or substituted C1 -C6 -alkyl; R2 is unsubstituted or substituted C1 -C | 12/31/2002 |
| 6486159 | Water soluble prodrugs of azole compounds Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula ##STR1## wherein A is the no... | 11/26/2002 |
| 6458830 | Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates to compounds of the formula (I): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are defined herein. The ... | 10/01/2002 |
| 6451833 | N-substituted (-imidazolyl-toluyl)pyrrole compounds for treatment of circulatory disorders A class of N-substituted (-imidazolyl-toluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein m is one; wherein each of R... | 09/17/2002 |
| 6448201 | Benzoylcyclohexanediones and benzoylpyrazoles, their preparation, and their use as herbicides and plant growth regulators Benzoylcyclohexanediones and benzoylpyrazoles, their preparation and their use as herbicides and plant growth regulators. There are described benzoyl compounds of the formula (I), their preparation and their use as herbicides and plant growth regulators. ... | 09/10/2002 |
| 6417187 | 1,2,4-triazole based compounds that can be used as insecticides or acaricides and processes 3-(Substituted aryl)-5-{substituted aryl-(alkynyl-aryl)}-[1,2,4]- triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and me... | 07/09/2002 |
| 6417358 | Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula (I), wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula (V), wherein the general symbols are as defined in claim 1, with carbon monoxide in the ... | 07/09/2002 |
| 6413997 | 3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds 3-(Substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of... | 07/02/2002 |
| 6395905 | Tetrahydroindazole derivatives as ligands for GABA-A 5 receptors 4-oxo-tetrahydroindozole-3-carboxamide compounds according to Formula (I), or a pharmaceutically acceptable salt thereof, are GABA-A Alpha 5 ligands useful for enhancing cognition: ##STR1##... | 05/28/2002 |
| 6376526 | Triazole antifungal agents An antifungal compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either entity, wherein X is CH or N; R1 is phenyl subsituted with 1 to 3 substituents each independently ... | 04/23/2002 |
