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| Number | Title | Issue Date |
| 7304081 | Amido compounds and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases... | 12/04/2007 |
| 7300934 | Benzamide nitriles Compounds of the formula (I) wherein m, n, A, R1, R2, R3, R4, R5 and R6 are as described herein, together with methods for making the compounds an... | 11/27/2007 |
| 7291640 | Substituted triazole derivatives as oxytocin antagonists The present invention relates to a class of substituted 1,2,4-triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety ... | 11/06/2007 |
| 7202367 | Process for arylating or vinylating or alkynating a nucleophilic compound The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the inventio... | 04/10/2007 |
| 7132437 | Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs are conjugates formed from two components, namely, a first component... | 11/07/2006 |
| 7084164 | Triazole derivative The invention relates to a triazole derivative with an activity inhibiting glycine transporter and for use as a pharmaceutical drug, and a novel triazole derivative. The inventive triazole derivative has an excellent activity inhibiting glycine transporter and is us... | 08/01/2006 |
| 7034047 | Triazole derivative The invention relates to a triazole derivative with an activity inhibiting glycine transporter and for use as a pharmaceutical drug, and a novel triazole derivative. The inventive triazole derivative has an excellent activity inhibiting glycine transporter and is us... | 04/25/2006 |
| 6750233 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibitin... | 06/15/2004 |
| 6541639 | Efficient ligand-mediated Ullmann coupling of anilines and azoles The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.... | 04/01/2003 |
| 6492525 | Organometallic complexes comprising cationic heterocyclic carbenes The invention concerns novel organometallic complexes comprising cationic heterocyclic carbenes. It also concerns a method for preparing said complexes from dicationic heterocyclic precursor compounds. It further concerns the use as catalysts of said orga... | 12/10/2002 |
| 6441177 | Tertiary amines Tertiary amines of the formula ##STR1## wherein A1, A2, A3, A4, M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.... | 08/27/2002 |
| 6414005 | Heterocyclic compounds having nos inhibitory activities Compounds represented by the general formula (1): ##STR1## [wherein R1 is typically an aminoalkyl group; R2 is typically a hydrogen atom, a lower alkyl group, R3 or SR4 (where R4 is typically a lower ... | 07/02/2002 |
| 6413996 | Diaminocyclobutene-3,4-dione derivatives, their preparation and use The invention relates to compounds having the formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), X represents a group having the structural formula (II), and Y represents O or S. The compounds of the invention can be used a chl... | 07/02/2002 |
| 6271179 | Benzylidene pyrazolones, production and use thereof Benzylidenepyrazolones of the formula I, ##STR1## Useful as herbicides.... | 08/07/2001 |
| 6159995 | Substituted diaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 12/12/2000 |
| 6063928 | 5-lipoxygenase inhibitors Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyr... | 05/16/2000 |
| 6004903 | 2-Anylocyclohexanediones having improved herbicidal properties Benzoyl derivatives of the formula I ##STR1## where Z is a 5-membered or 6-membered heterocyclic, saturated or unsaturated radical containing one to three hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen, Q is a cyclohex... | 12/21/1999 |
| 5985901 | Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both m... | 11/16/1999 |
| 5922744 | Ethane-1-2-diamine derivatives and tachykinin antagonists The present invention provides a compound of formula: ##STR1## wherein R, R1, R2, R3, R4, R5, R6a and R6b are defined herein or a pharmaceutically acceptable salt thereof, a... | 07/13/1999 |
| 5905087 | Iminooxybenzyl compounds and their use as pesticides and fungicides Iminooxybenzyl compounds of the formula I ##STR1## where R1 is C(CO2 Ra).dbd.CHRb, C(CO2 Ra).dbd.CHORb, C(CO2 Ra).dbd.NORb or C(CONRa ... | 05/18/1999 |
| 5795905 | CRF receptor antagonists and methods relating thereto CRF receptor antagonists are disclosed. Such receptor antagonists are thiadiazole-, pyrimidine-, triazine-, and triazole-containing compounds substituted with both a C3-C14 monocyclic or fused, homoaryl or heteroaryl group and a substituted amine group. T... | 08/18/1998 |
| 5705514 | Signal transduction inhibitor compounds A method of inhibiting the invasion and metastasis of malignant solid tumors in mammals, said method comprising administering to said mammal an anti-proliferative, anti-invasive and anti-metastasis effective amount of a compound selected from the group of... | 01/06/1998 |
| 5631381 | Process for the preparation of pesticidal 1-(haloaryl) heterocyclic compounds Process for preparing complex pesticidal 1-(haloaryl)heterocyclic compounds by reacting 1-(nitroaryl)heterocycles with metallic halide salts.... | 05/20/1997 |
| 5359078 | Signal transduction inhibitor compounds A compound having the formula: Y--(CH2)p --Ar11 --X--Ar12 wherein: p is an integer of from 0 to 4; Ar11 and Ar12 are each aromatic moieties independently selected from the group consisting of phenyl,... | 10/25/1994 |
| 5310918 | 1-aryl-substituted azole, non-linear optical material and novel molecular crystal containing same and method and module for the conversion of light wavelength using same Disclosed is a non-linear optical material represented by the following formula: ##STR1## wherein X represents a methyl group or a hydrogen atom, with the proviso that when X is a methyl group, A represents a nitrogen atom, Y represents a methyl... | 05/10/1994 |
| 5053071 | Chromane herbicides This invention pertains to novel heterocyclic 2,3-dihydrobenzofuran and chromane compounds, including stereoisomers, agriculturally suitable compositions containing them, and their use as broad spectrum herbicides.... | 10/01/1991 |
| 4209516 | Triazole derivatives The present invention relates to new triazole derivatives of the formula ##STR1## wherein R1 represents hydrogen, lower alkyl, optionally esterified or etherified hydroxymethyl, formyl, optionally functionally modified carboxy, or optional... | 06/24/1980 |
| 4209515 | Triazole derivatives The present invention relates to new triazole derivatives of the formula ##STR1## wherein R1 represents hydrogen, lower alkyl, optionally esterified or etherified hydroxymethyl, formyl, optionally functionally modified carboxy, or optional... | 06/24/1980 |
| 4159374 | Triazolylphenyl ketone derivatives and production thereof Triazolyl ketone derivatives of the formula: ##STR1## (wherein R represents lower alkoxy or the group ##STR2## R4 and R5 each represents hydrogen, lower alkyl, ##STR3## represents hetero ring selected from pyrrolidino,... | 06/26/1979 |
| 4147700 | Triazolylbenzophenone derivatives and production thereof Triazolylbenzophenone derivatives of the formula: ##STR1## (wherein R represents hydrogen, C1 -C6 alkyl, C1 -C6 halo-alkyl, the group --(CH2)n --X--R5, or the group ##STR2##... | 04/03/1979 |
| 4143048 | Process for producing triazolylbenzophenone derivatives Triazolylbenzophenone derivatives of the formula: ##STR1## (wherein R represents hydrogen, C1 -C6 alkyl, C1 -C6 halo-alkyl, the group --(CH2)n --X--R5, or the group ##STR2##... | 03/06/1979 |
| 4141901 | Process for producing triazolylbenzophenone derivatives Triazolylbenzophenone derivatives of the formula: ##STR1## (wherein R represents hydrogen, C1 -C6 alkyl, C1 -C6 halo-alkyl, the group --(CH2)n -X-R5, or the group ##STR2## ... | 02/27/1979 |
| 4111950 | Triazolyl benzophenones Compounds of the class of 6-phenyl-4H-s-triazolo[1,5-a][1,4]benzodiazepine-2-carboxamides, their 5-oxides and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties and are active ingredients for therapeutic co... | 09/05/1978 |
| 4069229 | Substituted phenyl ketones This invention is directed toward pharmacologically active compounds of the formula ##STR1## wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C1-4 alkyl)aminoethyl, methoxymethyl or hydr... | 01/17/1978 |
| 4010177 | [3-Substituted-5-[(di-methylamino)methyl]-4H-1,2,4-triazol- 4-yl]benzophenones and process Compounds of the formula I: ##STR1## wherein R1 is hydroxymethyl, or -CH2 NR6 R7, in which R6 is -CH2 -C.tbd.CH, -CH2 -CH=CH2, ##STR2## or alkyl of 1 to 3 ca... | 03/01/1977 |
| 4007219 | Benzophenone glycinamide derivatives This invention is directed toward pharmacologically active compounds of the formula ##STR1## wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C1-4 alkyl)aminoethyl, methoxymethyl or hydr... | 02/08/1977 |
| 4000151 | Triazolyl benzophenone compounds Intermediates of the formula IV: ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, inclusive; and wherein R2, R3, and R4 are selected from the group consisting of h... | 12/28/1976 |
| 4000153 | Triazolobenzodiazepine intermediates Intermediates of the formula VI: ##STR1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms, inclusive, wherein R2 is hydrogen, fluoro, or chloro; wherein R3 is hydrogen or fluoro with the proviso that R3 is not f... | 12/28/1976 |
| 3994940 | Preparation of 1-(2-(dimethylamino)ethyl)-6-phenyl-4H-5-triazolo(4,3-a)(1,4)benzodiazep ines A process for the production of known compounds of the formula IV ##SPC1## wherein R1 is hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R2 is hydrogen, chloro, or fluoro; wherein R3 is hydrogen, or fluoro wit... | 11/30/1976 |
| 3993660 | 2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones A process to make 6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepines by converting 2-[3-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenones to 2-[3-[(phthalimido or methanesulfonyl)methyl]-4H-1,2,4-triazol-4-yl]benzophenones and converting these comp... | 11/23/1976 |
