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| Number | Title | Issue Date |
| 8183384 | Triazole compounds that modulate HSP90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treati... | 05/22/2012 |
| 8022225 | Triazole derivative A compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof has an effect of inhibiting binding between S1P and its receptor Edg-1(S1P1), and is useful as a pharmaceutical product. ... | 09/20/2011 |
| 7919629 | Sulphonyl-1,2,4-triazole salts The invention relates to triazole salts, to their preparation and to applications thereof. The salts have at least one anionic triazolium group which carries at least one chlorosulphonyl, fluorosulphonyl or alkoxyfluorosulphonyl group, each of the anionic groups bei... | 04/05/2011 |
| 7893276 | Process for preparing triazolones The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones 20. ... | 02/22/2011 |
| 7476743 | Compounds, compositions, and methods 1,2,4-Tiazole-5-ones useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 01/13/2009 |
| 7435752 | N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl]--amino benozioc acids as HIV reverse transcriptase inhibitors A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O)N-linked amino acid. The compound... | 10/14/2008 |
| RE40183 | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula wherein R, X, R5 and R6 are defined in the specification. The compounds of the invention ... | 03/25/2008 |
| 7309721 | Aminoalkylphosphonates and related compounds as Edg receptor agonists The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejecti... | 12/18/2007 |
| 7304062 | Peroxisome proliferator activated receptor alpha agonists The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C | 12/04/2007 |
| 7279444 | Substituted benzoylpyrazoles The invention relates to novel substituted benzoylpyrazoles of the formula (I), in which n, A, R1, R2, R3, R4, Y, and Z are as defined herein, ... | 10/09/2007 |
| 7241787 | Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments The invention relates to substituted N-cyclohexylheterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to processes for their preparation and to their use as medicaments. Compounds of the formula I, | 07/10/2007 |
| 7238720 | Pharmaceutical use of N-carbamoylazole derivatives The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl... | 07/03/2007 |
| 7235671 | Process for preparing 3-chloromethyl-1,2,4-triazolin-5-one The present invention is directed to processes for the preparation of 3-chloromethyl-1,2,4-triazolin-5-one. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity. Also disclosed are novel semicarbazide salts ... | 06/26/2007 |
| RE39607 | Herbicidal sulphonylamino(thio) carbonyl compounds The invention relates to novel sulphonylamino(thio) carbonyl compounds of the formula (I), in which A represents a single bond, oxygen, sulphur or the group N—R, in which R represents hydrogen... | 05/01/2007 |
| 7208509 | Non-nucleoside reverse transcriptase inhibitors This invention relates to novel heterocyclic compounds of formula I wherein R1—R4, X1 and X2 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human ... | 04/24/2007 |
| 7176226 | Crystal modification II of 2-[2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione This invention relates to crystal form II of 2-[2-(1-chlorocyclopropyl)-3-(2-chloropenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione of the formula to a process for its preparation and to its use for... | 02/13/2007 |
| 7148226 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The ... | 12/12/2006 |
| 7144908 | Agonists of beta-adrenoceptors The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. | 12/05/2006 |
| 7138140 | Suplatast tosilate crystals Provided are a suplatast tosilate crystal showing characteristic peaks in powder X-ray diffraction diffraction angles (20±0.1°) of 5.6°, 9.0°, 11.0°, 15.3°, 16.5°, 17.2°, 17.9°, 19.2°, 19.9°, and 21.5°; and a preparation process of the crystal. Owing to ... | 11/21/2006 |
| RE39263 | Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides of the general formula (I) useful as herbicides. ... | 09/05/2006 |
| 7078424 | N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating... | 07/18/2006 |
| 7071223 | Benzamide inhibitors of the P2Xreceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1–R3 are as defined herein. The compounds of the invention are useful in the trea... | 07/04/2006 |
| 7067656 | Sulfamoyl compounds and agricultural and horticultural fungicides A sulfamoyl compound of the general formulae (1): wherein R1 and R2 are each independently C1-4 alkyl, or R1 and R2 togeth... | 06/27/2006 |
| 7060829 | Colorant compounds containing copolymerizable vinyl groups Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coa... | 06/13/2006 |
| 7056941 | 2-[pyrazolyl and triazolyl-3′-oxymethylene]-phenyl-isoxazolones, triazolones and tetrazolones as pesticides and fungicides 2-[Pyrazolyl- and triazolyl-3′-oxymethylene]phenylisoxazolones, -triazolones and -tetrazolones of formula I where: X is a group A, B or C, | 06/06/2006 |
| 7037880 | Ethylene derivatives and pesticides containing said derivatives Ethylene derivatives of formula (I): where Q is an unsubstituted or substituted phenyl or heterocyclic group, especially a 4-thiazolyl, 1- or 3-pyrazolyl, 1,3-oxazol-4-yl, phenyl or pyridyl group; E is a substituent su... | 05/02/2006 |
| 6969697 | Substituted benzoylcyclohexenones The invention relates to novel substituted benzoylcyclohexenones of the formula (I), in which n, A, R1, R2, R3, R4, Y and Z are each as defined in the descriptio... | 11/29/2005 |
| 6969727 | Heterocyclic aromatic compounds useful as growth hormone secretagogues Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocyclic a... | 11/29/2005 |
| 6964939 | Substituted thiene-3-yl-sulfonyl amino(thio)carbonyl-triazolin(thi)ones The invention relates to novel substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(ethi)ones of the general formula (I) in which Q1, Q2, R1, R2, R... | 11/15/2005 |
| 6933390 | Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of fur... | 08/23/2005 |
| 6924251 | Substituted benzoylcyclohexandiones The invention relates to novel substituted benzoylcyclohexanediones of the general formula (I), in which m, n, A, R1, R2, R3, R4 and Z are each as defined in the... | 08/02/2005 |
| 6906006 | N-arly-substituted nitrogen-containing heterocycles, processes and novel intermediates for their preparation, and their use as herbicides and plant growth regulators Substituted triazolinone compounds of the formula: wherein the variables R1, R2, R7, R8, R12 and X are as defined in the specification are useful as herbicides, pl... | 06/14/2005 |
| 6906085 | Tetrahydropyran derivatives as neurokinin receptor antagonists The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7 and R8 represent a variety of subst... | 06/14/2005 |
| 6864219 | Substituted aryl ketones The invention relates to novel substituted aryl ketones of the general formula (I) wherein all variables are as defined in the specification, and to processes for their preparation, to intermediates and to the use of t... | 03/08/2005 |
| 6831174 | Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and... | 12/14/2004 |
| 6762197 | Difluoromethyltriazolone compounds, use of the same and intermediates for the production thereof A triazolone compound of the formula [I]: wherein; R1 represents optionally substituted phenyl or the like, T represents m-phenylene optionally substituted by methyl or the like; and a fungicidal... | 07/13/2004 |
| 6762152 | Substituted benzoyl ketones, methods for producing them and their use as herbicides The invention relates to novel substituted benzoyl ketones of the formula (I) in which n represents 0, 1, 2 or 3, A represents a single bond or represents alkanediyl (alkylene), R1 represe... | 07/13/2004 |
| 6746989 | Substituted benzoylpyrazoles as herbicides The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which n represents the numbers 0, 1, 2 or 3, A represents a single bond or represents alkanediyl(alkylene), ... | 06/08/2004 |
| 6677277 | Substituted sulphonyl amino(thio)carbonyl compounds and their use as herbicides The invention relates to novel sulfonylamino(thio)carbonyl compounds of the formula (I), ##STR1## in which n represents the numbers 0, 1 or 2, A represents a single bond, or oxygen or sulfur, or the grouping N--R, in which R represents hydrogen, a... | 01/13/2004 |
| 6673939 | Process for the preparation of 1,2,4-triazolin-5-one derivatives The present invention relates to a process for the preparation of a compound of formula (I) wherein R represents hydrogen, C1-10 alkyl, haloC1-10 alkyl or aryl; which are useful intermediates in the preparation of morpholine derivati... | 01/06/2004 |
