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...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8076492 | Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil A process for the preparation of trityl olmesartan comprising (a) condensing 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazol-5-carboxylic acid alkyl ester with trityl biphenyl bromide in the presence of a polar aprotic solvent and a base selected from the group consis... | 12/13/2011 |
| 8071784 | Lead-free primary explosive composition and method of preparation Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matt... | 12/06/2011 |
| 8053582 | Process for making tetrazole based cross-linked polymers A cross-linked polyisocyanate polymer and a process for preparation of a polymer having the general structure (I) including reacting an effective amount of tetrazole polyol with isocyanate resin, combining at a temperature in the range of about 50° C. to about 100Â... | 11/08/2011 |
| 8039636 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, where Ar1 is —C3-C8 cycloalkyl, phenyl, n... | 10/18/2011 |
| 7943779 | Process for the preparation of olmesartan medoxomil The present invention relates to an improved process for the manufacture of olmesartan and pharmaceutically acceptable salts and esters thereof as an active ingredient of a medicament for the treatment of hypertension and related diseases and conditions. ... | 05/17/2011 |
| 7923566 | Alternative process for the preparation of losartan The invention relates to an improved process for the preparation of Losartan. The process comprising reacting 2-n-butyl-4-chloro-5-formyl imidazole with 2-(4-bromomethyl) benzonitrile in the presence of a phase transfer catalyst and an alkali, and reducing the resul... | 04/12/2011 |
| 7884212 | Process for the preparation of candesartan cilexetil The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which compris... | 02/08/2011 |
| 7880014 | Angiotensin II receptor antagonists A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is -Y1-Y2-Y3-Y4-Y5-; Y1 is C(R1R2); R | 02/01/2011 |
| 7880015 | Process for the preparation of angiotensin II antagonist The present invention provides a method for the preparation of N-(1-oxopentyl)-N-[[2′-(1H-tetra-zol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine (Valsartan) which comprises; treating N-[[2′-(1-triphenylmethyl-tetra-zol-5-yl)biphenyl-4-yl]methyl]-L-valine methyl ... | 02/01/2011 |
| 7838683 | Synthesis of irbesartan Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected ... | 11/23/2010 |
| 7745633 | Tetrazole based linear polymers A linear isocyanate polymer produced by utilizing an effective amount of tetrazole diol or tetrazole polyol, reacting with an effective amount isocyanate resin, and cooling to room temperature producing a linear polyisocyanate polymer. ... | 06/29/2010 |
| 7741492 | Method for obtaining a pharmaceutically active compound (Irbesartan) and its synthesis intermediate It is provided a method for obtaining Irbesartan polymorph A, with few synthesis steps, by coupling the intermediate of formula (II) with the compound of formula (III), neutralising one of its alkaline salts in an aqueous medium and recrystallising the crude product... | 06/22/2010 |
| 7723529 | Process for preparing nitrooxy esters, nitrooxy thioesters nitrooxy carbonates and nitrooxy thiocarbinates, intermediates useful in said process and preparation thereof The present invention relates to a process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates of compounds having at least an hydroxyl or thiol functional group, according to the following reaction scheme | 05/25/2010 |
| 7714143 | Method of making monoammonium salt of 5,5′-bis-1H-tetrazole A method of forming monoammonium salt of 5,5′-bis-1H-tetrazole (BTA-1NH3) is presented comprising the steps of charging a mixing vessel with a solution of free BTA acid and distilled water, adding ammonium hydroxide in excess to obtain a pH of at least 9.5 and mix... | 05/11/2010 |
| 7709655 | Clickphosphines for transition metal-catalyzed reactions Phosphine triazole ligand compounds, prepared through click chemistry, complex with transition metals to form transition metal-phosphine triazole ligand complexes. These complexes are useful catalysts in coupling reactions such as Suzuki-Miyaura coupling, Stille cou... | 05/04/2010 |
| 7692024 | Gas generant compositions A novel compound, used for example, as a gas generating fuel, is defined as a compound having the structural formula of R3—R1—R2, wherein R1 is a benzene ring with nitro substitution, R2 is a tetrazolyl group with a C—C bond to... | 04/06/2010 |
| 7692023 | Candesartan cilexetil polymorphs Provided are candesartan cilexetil forms and methods of their preparation. Also provided are pharmaceutical compositions prepared by combining at least one pharmaceutically-acceptable execipient with at least one candesartan cilexetil form of the invention. ... | 04/06/2010 |
| 7667045 | Gas generant and synthesis A vinylated tetrazole substituted at the 5-position of the tetrazole ring is formed by a water-based method. A gas generating composition 12 containing the vinylated tetrazole is contained within an exemplary gas generator 10. A gas generating system | 02/23/2010 |
| 7652147 | Process for preparation of Irbesartan A process for the preparation of Irbesartan of formula (I) using the steps of: (i) reacting 4′ aminomethyl-2-cyano biphenyl of formula (VI) with 1-veleramido cyclopentane carboxylic acid... | 01/26/2010 |
| 7579480 | Alkoxy-(tetrazol-1-yl)benzaldehyde compound and process for producing the same The present invention relates to a process for producing an alkoxy-(tetrazol-1-yl)benzaldehyde compound represented by Formula (2): wherein A1 is an alkoxy group, and A2 is a hydrogen atom, alkyl group... | 08/25/2009 |
| 7557219 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, where Ar1 is —C3-C8 cycloalkyl, phenyl, n... | 07/07/2009 |
| 7528257 | Process for making di-functional tetrazole diols to produce tetrazole base polymers A process for making energetic cast cured binders by making di-tetrazoles to produce di-functional tetrazole diols for producing tetrazole base polymers. Embodiments of the present invention relates generally to a process for preparation of a monomer including react... | 05/05/2009 |
| 7517997 | Process for making tetrazole based cross-linked polymers A cross-linked polyisocyanate polymer and a process for preparation of a polymer having the general structure (I) including reacting an effective amount of tetrazole polyol with isocyanate resin, combining at a temperature in the range of about 50° C. to about 100Â... | 04/14/2009 |
| 7498446 | Primary explosives The present invention provides a compound of the formula (Cat)+z[M++(5-nitro-1H-tetrazolato-N2)−x(H2O)y] where x is 3 or 4, y is 2 or 3, x+y is 6, z is 1 or 2, and M++ is selec... | 03/03/2009 |
| 7446208 | Process for making tetrazole based linear polymers A process for preparation of polymers including reacting an effective amount of tetrazole diols or tetrazole polyols with isocyanate resins to produce tetrazole based linear isocyanate polymers. ... | 11/04/2008 |
| 7402679 | One-pot process for making multifunctional tetrazole polyols to produce tetrazole based polymers A process for making energetic urethane cured binders by making poly-tetrazoles to produce multi-functional tetrazole polyols for producing tetrazole base polymers. Embodiments of the present invention relate generally to a process for preparation of a monomer inclu... | 07/22/2008 |
| 7396938 | Process for making multifunctional tetrazole polyols to produce tetrazole based polymers A process for making energetic cured binders by making poly-tetrazoles to produce multi-functional tetrazole polyols for producing tetrazole base polymers. Embodiments of the present invention relate generally to a process for preparation of a monomer including reac... | 07/08/2008 |
| 7385062 | Process for the preparation of phenyltetrazole derivatives A process for the preparation of phenyltetrazole derivatives of formula (II) wherein R and Y are as defined in the disclosure, by direct ortho-metallation of (tetrazol-5-γl)benzene. The compounds of formula (II) are useful intermediates for the preparation of angio... | 06/10/2008 |
| 7378433 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-... | 05/27/2008 |
| 7378421 | Chromenone derivatives Novel compounds of the formula I in which R1, R2, R3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for... | 05/27/2008 |
| 7361770 | Process for preparation of valsartan Valsartan of formula (I) is prepared by hydrolysis of valsartan benzyl ester with an alkali metal hydroxide, washing with an organic solvent, acidifying with hydrochloric acid and isolating valsartan from the reaction mixture ... | 04/22/2008 |
| 7361677 | Polycyclic sulphamate compounds suitable for use as inhibitors of aromatase and/or sulphatase There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the v... | 04/22/2008 |
| 7345072 | Phenyltetrazole compounds Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules. ... | 03/18/2008 |
| 7341606 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and at least one bicyclic fused 5-5-membered aza heteroaromatic keratin dyeing compounds having a ring junction nitrogen and an N-hydroxy or N-amino group and derivative... | 03/11/2008 |
| 7342039 | Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them. ... | 03/11/2008 |
| 7332514 | Dibenzylamine compound and medicinal use thereof A dibenzylamine compound represented by the formula (1) wherein R1 and R2 are each a C1-6 alkyl group optionally substituted by halogen atoms and the like; R3, R4 ... | 02/19/2008 |
| 7332612 | Amorphous and crystalline forms of losartan potassium and process for their preparation This invention relates to novel amorphous losartan potassium, novel losartan potassium in a crystalline form that is a hydrate, novel crystalline losartan potassium Form IV and solvates thereof, novel crystalline losartan potassium Form V and solvates thereof, to pr... | 02/19/2008 |
| 7326812 | Arylsulfonamidobenzylic compounds Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases. ... | 02/05/2008 |
| 7312340 | Synthesis of 2-butyl-3-(1-trityl-1H-tetrazol-5-YL)biphenyl-4-YL)-1,3-diazaspiro[4,4]- non-ene-4-one Provided is a novel method of making 2-butyl-3-[[2′(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan. ... | 12/25/2007 |
| 7301028 | Mitotic kinesin inhibitors The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which com... | 11/27/2007 |
