Bizarre Patents
A kissing shield comprised of a thin, flexible membrane and a frame or holder.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8044214 | Process for preparing isoxazole compounds A process for preparing isoxazole compounds of formula I: in which a nitroaryl of the formula (II): is contacted with an alkyl acetoacetate of the formula (III) or a salt thereof:... | 10/25/2011 |
| 7495107 | Method for manufacturing isoxazole derivative or dihydroisoxazole derivative There is provided with a method for manufacturing an isoxazole derivative at a high yield and without discharging waste products, and a novel isoxazole derivative. An isoxazole derivative expressed by Formula (8) is produced by reacting a 1-alkyne compound expressed... | 02/24/2009 |
| 7402606 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle ... | 07/22/2008 |
| 7388017 | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, eith... | 06/17/2008 |
| 7388025 | 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives The present invention is concerned with 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives of formula I wherein R1, R2, and R3 are as defined in the specif... | 06/17/2008 |
| 7378435 | Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives The present invention is concerned with aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives of formula I wherein R1, R2, R3, R4, ... | 05/27/2008 |
| 7378448 | Diphenylether amide derivatives as opioid receptor antagonists A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7 including R3′, p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mi... | 05/27/2008 |
| 7371755 | Antiviral agents This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties. ... | 05/13/2008 |
| 7291743 | Isoxazole derivatives and methods of treating nitric oxide mediated diseases A series of isoxazole derivatives and methods of suppressing, inhibiting, or preventing disorders mediated by nitric oxide (NO) and/or proinflammatory cytokines, such as TNF-α (tumor necrosis factor alpha), IL-1 (interlukin-1), and IL-6, are described. ... | 11/06/2007 |
| 7273882 | Aminoacetamide acyl guanidines as β-secretase inhibitors There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R | 09/25/2007 |
| 7223774 | Benzamide 2-hydroxy-3-diaminoalkanes The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/29/2007 |
| 7208528 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 04/24/2007 |
| 7179804 | Tachykinin receptor antagonists The present invention relates to selective NK-1 receptor antagonists of Formula (I); or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins ... | 02/20/2007 |
| 7138420 | Substituted benzimidazole compounds Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit It... | 11/21/2006 |
| 7135434 | Combinations of herbicides and safeners This invention provides for, inter alia, a herbicidal composition comprising a mixture of: A. a herbicidally effective amount of at least one compound of the formula where V and Z are defined in the specification... | 11/14/2006 |
| 7126026 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NHE1 inhibitors and can be employed, f... | 10/24/2006 |
| 7112554 | Substituted arylketones The invention relates to novel aryl ketones of the formula (I) in which A1, A2, Q, R1, R2, X, Y and Z are as defined in the descripti... | 09/26/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7034046 | NR1H4 nuclear receptor binding compounds The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists and antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through... | 04/25/2006 |
| 7034049 | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3–C6 cycloalkyl group optionally substituted by a straight or branched C1–C6 alkyl or arylalkyl group; R1 is a straig... | 04/25/2006 |
| 6995272 | Crystal form of N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide The invention relates to a crystal modification of the compound of the formula I and the processes for the preparation of and use that crystal modifications 1. The invention is used for treating acute immunological epis... | 02/07/2006 |
| 6995142 | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compoun... | 02/07/2006 |
| 6984735 | Process for making an aldehyde A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a ... | 01/10/2006 |
| 6949567 | Compounds for the treatment of protozoal diseases The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to pro... | 09/27/2005 |
| 6936570 | Tetrazolinone derivatives The invention relates to novel tetrazolinone derivatives of general formula (I) wherein R1 represents halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylsulfonyl, C1-4 | 08/30/2005 |
| 6924297 | Naphathalene derivatives which bind to the EP4 receptor Compounds of formula (I) and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunol... | 08/02/2005 |
| 6914160 | Oxytocin inhibitors This invention relates to compounds of formula (I) ... | 07/05/2005 |
| 6908923 | Compositions and methods for treating heart failure Certain substituted benzamide derivatives of Formula I: selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including conges... | 06/21/2005 |
| 6900334 | Crystal form on N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide The invention relates to a crystal modification of the compound of the formula I and the processes for the preparation of and use that crystal modifications 1. The invention is used for treating acute immunologi... | 05/31/2005 |
| 6887877 | Compounds and methods for the treatment or prevention of Flavivirus infections The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating Flaviviridae viral infection. ... | 05/03/2005 |
| 6852744 | Pyrrolidine derivatives and their use as chymase inhibitor Novel pyrrolidine derivatives, being useful as chymase inhibitor or intermediate for synthesis of the active compounds, which has the formula (I): wherein R1 is cycloalkyl, substituted or unsubstituted phenyl or naphthyl, indanyl, thienyl, furyl, substitu... | 02/08/2005 |
| 6838415 | Substituted benzoylisoxazoles and the use thereof as herbicides The invention relates to novel substituted benzoylisoxazoles of the general formula (I), in which n represents the number 0, 1, 2 or 3, A represents a single bond or ... | 01/04/2005 |
| 6825219 | Substituted benzimidazole compounds Disclosed are substituted benzimidazole compounds of formula(I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention are useful for tr... | 11/30/2004 |
| 6821964 | Modulators of chemokine receptor activity Chemokine receptor antagonists, in particular, bicyclic diamine compounds of Formula (I) that act as antagonists of chemokine CCR2 and CCR3 receptors including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumul... | 11/23/2004 |
| 6806373 | Process for preparing leflunomide form I New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositi... | 10/19/2004 |
| 6803384 | Diaminopropionic acid derivatives A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusi... | 10/12/2004 |
| 6747047 | Insecticidal anthranilamides This invention provides compounds of Formula (1), their N-oxides and agriculturally suitable salts wherein A, B, J, R1, R2, R3 and R4 and n are as defined in the disclosure. Also disclosed are methods for controlling arthr... | 06/08/2004 |
| 6727272 | Leflunomide analogs for treating rheumatoid arthritis Novel leflunomide analogs were synthesized and evaluated in-vivo. Based on the in-vivo studies, these analogs are surprisingly effective for treating rheumatoid arthritis. ... | 04/27/2004 |
| 6723855 | Method for synthesizing leflunomide A process for synthesizing leflunomide from 5-methylisoxazole-4-carboxylic acid and 4-trifluoromethylaniline is provided in which the carboxylic acid group of 5-methylisoxazole-4-carboxylic acid is chlorinated, forming 5-methylisoxazole-4-carboxylic acid chloride. T... | 04/20/2004 |
| 6649629 | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compou... | 11/18/2003 |
