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| Number | Title | Issue Date |
| 7202257 | Anti-inflammatory medicaments Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel com... | 04/10/2007 |
| 7084163 | Heterocyclic carboxamides and their use as fungicides Compounds of general formula (I), in which Het represents a five or six membered saturated, partially unsaturated or aromatic ring containing between one and six heteroatoms of the group N, O, S, in which the heterocycle is substituted in an adjacent manner with -P-... | 08/01/2006 |
| 7081538 | Substituted isoxazolines and their use as antibacterial agents Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is O, S or NH; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selecte... | 07/25/2006 |
| 6835842 | 3-nitroisoxazoles and their use in the protection of materials The 3-nitroisoxazoles of the formula (I) in which R1 and R2 are each as defined in the description, some of which are known, are highly suitable for use as biocides for pr... | 12/28/2004 |
| 6833370 | Heterocycle substituted aminoazacycles useful as central nervous system agents Heterocyclic substituted aminoazacyclic compounds of formula I Z—R3 I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said comp... | 12/21/2004 |
| 6746989 | Substituted benzoylpyrazoles as herbicides The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which n represents the numbers 0, 1, 2 or 3, A represents a single bond or represents alkanediyl(alkylene), ... | 06/08/2004 |
| 6420567 | N-heteroaryl aryl-substituted thienyl-furyl-and pyrrolyl-sulfonamides and derviatives thereof that modulate the activity of endothelin Thienyl-, furyl- and pyrrolyl-sulfonamides, formulations of pharmaceutically-acceptable salts thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, ... | 07/16/2002 |
| 6387915 | Isoxazole-sulfonamide endothelin antagonists Isoxazole-sulfonamide endothelin antagonists of formula (I) below having good affinity for endothelin receptors and selectivity for ETA over ETB are described herein. ##STR1## Such compounds are useful in the treatment of conditions ... | 05/14/2002 |
| 6384066 | Sulphonyltriazol derivatives and their use for combating micro-organisms Novel sulphonyltriazole derivatives of the formula ##STR1## in which Hal represents fluorine, chlorine or bromine, R1 represents hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkylaminocarbonyl, optionally substituted phenyl, optionally substituted ... | 05/07/2002 |
| 6331637 | N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin N-alkyl, N-alkenyl, N-alkynyl, N-aryl and N-fused bicyclo or tricyclo thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, (phenyl) and (phenoxy)th... | 12/18/2001 |
| 6107320 | Phenyl sulfonamide endothelin antagonists Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R1, R2 and R3 are each independently (a) hydrogen, except that R1 is other than hydrogen; (b) alkyl, alke... | 08/22/2000 |
| 6080774 | Substituted biphenylsulfonamide endothelin antagonists Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: ##STR2## R2 and R3 are each independently (a) hydrogen; (b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, ... | 06/27/2000 |
| 6057342 | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a... | 05/02/2000 |
| 6022977 | Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids The present invention relates generally to a novel method for preparation of substituted isoxazolin-5-yl acetic acid in high optical purity from a stereoisomeric mixture of an esterified substituted isoxazolin-5-yl acetate. The products are useful in the ... | 02/08/2000 |
| 6020354 | Halobenzimidazoles and their use as microbicides New halogenobenzimidazoles of the formula in which A, R1, R2, R3, R4 and X have the meanings given in the description, and their acid addition salts and metal salt complexes, a process for their preparation and their use ... | 02/01/2000 |
| 5962490 | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)-furylsulfonamides and N-(isoxazolyl)pyrrolyl... | 10/05/1999 |
| 5939418 | Isoxazoline, isothiazoline and pyrazoline factor Xa inhibitors Isoxazolines, isothiazolines and pyrazolines which are inhibitors of Factor Xa, pharmaceutical compositions containing these compounds, and methods of using these compounds as anticoagulant agents for treatment and prevention of thromboembolic disorders. ... | 08/17/1999 |
| 5935973 | Heterocyclcarboxamide derivatives and their use as therapeutic agents Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R1 is an optional substituent; U is an alkylene chain optionally substituted by one or more... | 08/10/1999 |
| 5856507 | Methods for the preparation of biphenyl isoxazole sulfonamides Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endo... | 01/05/1999 |
| 5686434 | 3-aryl-2-isoxazolines as antiinflammatory agents This invention relates to 3-aryl-2-isoxazoline compounds which are selective inhibitors of phosphodiesterase type IV (PDEIV). The 3-aryl-2-isoxazolines are useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulm... | 11/11/1997 |
| 5621109 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed wherein the terms R1, R2, R5, R6, Y, Y', m and n are herein defined.... | 04/15/1997 |
| 5599942 | Taxoid intermediates Taxoids having a 1,3-oxazole containing moiety at the 13-position of the taxane nucleus.... | 02/04/1997 |
| 5594021 | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolyls... | 01/14/1997 |
| 5591761 | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin Thiophenyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, isoxazolyl-thiophenyl-sulfonamides, isoxazolyl-furyl-sulfonamides and isoxazolyl-pyrrolyl-s... | 01/07/1997 |
| 5580894 | Isoxazolyl enaminones An oxazolyl enaminone is provided having the formula: ##STR1## wherein R1 is selected from the group consisting of a branched or unbranched alkyl groups containing from 1 to 4 carbon atoms and R2 is selected from the group consi... | 12/03/1996 |
| 5571821 | Sulfonamides and derivatives thereof that modulate the activity of endothelin Sulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administeri... | 11/05/1996 |
| 5571810 | Thiophene derivatives This invention relates to new thiophene derivatives having antiinflammatory and analgesic activities and represented by the general formula [I]: ##STR1## wherein R1 is hydrogen, halogen, cyano, substituted lower alkyl, substituted or unsub... | 11/05/1996 |
| 5523302 | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other thera... | 06/04/1996 |
| 5514691 | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin N-(4-halo-isoxazolyl)sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(4-halo-3-isoxazolyl)sulfonamides and N-(4-halo-5-isoxazolyl)benzenesulfonamides and methods for inhi... | 05/07/1996 |
| 5514696 | Phenyl sulfonamide endothelin antagonists Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R1, R2 and R3 are each independently (a) hydrogen, except that R1 is other than hydrogen; (b) alkyl, alke... | 05/07/1996 |
| 5464853 | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin N-(5-isoxazolyl)biphenylsulfonamides and N-(3-isoxazolyl)biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(5-isoxazolyl)biphenylsulfonamides and N-(3-isoxazol... | 11/07/1995 |
| 5378715 | Sulfonamide endothelin antagonists Compounds of the formula ##STR1## inhibit endothelin, wherein: one of X and Y is N and the other is O; R is naphthyl or naphthyl substituted with R1, R2 and R3 ; R1, R2 and R3 are each inde... | 01/03/1995 |
| 5318720 | Liquid crystal composition, liquid crystal device, display apparatus and display method A mesomorphic compound represented by the following formula (I): ##STR1## wherein R1 and R2 respectively denote an alkyl group or alkoxy group each having 4-16 carbon atoms optionally substituted, halogen, --CN or --CF3. | 06/07/1994 |
| 5292737 | N,N'-bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-bis(amido)-2-amino-4-iminonaphthalen-1-ones N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-ones are disclosed. Methods of inhibiting protein kinase C activity which comprises contacting protein kinase C with an effective amount of an N,N'... | 03/08/1994 |
| 5290802 | 3-substituted-2-oxindole derivatives This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H | 03/01/1994 |
| 5273989 | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use Novel 3,5-disubstituted 2-isoxazolines and isoxazoles and novel pharmaceuticals are described which are suitable, in particular, for the prophylaxis and/or treatment of pathological, neurodegenerative disorders in humans and animals. Processes for the pre... | 12/28/1993 |
| 5256784 | Nonlineaphores and polymers incorporating such nonlineaphores Nonlinear-optic (NLO) compositions containing functionalized merocyanine dyes, such that the molecules, comprising the NLO-active compositions have a functional group at each end of the molecule and each functional group differing in reactivity, thus perm... | 10/26/1993 |
| 5245040 | Process for the preparation of nitroguanidine derivatives A process for the preparation of 1,3-disubstituted 2-nitroguanidines of the formula I ##STR1## in which R1 is hydrogen or C1 -C4 alkyl, R2 is hydrogen, C1 -C6 alkyl, C3 -C | 09/14/1993 |
| 5207816 | Cyclohexenone derivatives and their use for controlling undesirable plant growth Cyclohexenone derivatives of the formula ##STR1## where R1 is alkyl, R2 is alkyl, unsubstituted or halogen-substituted alkenyl or alkynyl, X is a substituted or unsubstituted five-membered heteroaromatic radical, and Z is hydrog... | 05/04/1993 |
| 5196541 | Process for the preparation of substituted 3-aminoacrylic esters There is described a new process for the preparation of substituted 3-aminoacrylic esters of the general formula (I) ##STR1## in which R1, R2, R3, R4, X and n have the meaning given in the description. The ... | 03/23/1993 |
