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| Number | Title | Issue Date |
| 8293920 | Synthesis of enone intermediate The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously suscep... | 10/23/2012 |
| 8071783 | -heterocyclic carbene catalyzed synthesis of -phenylisoxazolidin-5-one derivative and synthesis of β-amino acid ester derivative A process for preparing a N-phenylisoxazolidin-5-one derivative is provided. The process for preparing the N-phenylisoxazolidin-5-one derivative comprises reacting an α,β-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) ca... | 12/06/2011 |
| 7714142 | Process for production of (4,5-dihydroisoxazol-3-Y) thio-carboxamidine salts To provide a method for producing a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound simply, safely and in good yield, whereby drawbacks of prior art have been solved. A method for producing a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound... | 05/11/2010 |
| 7405226 | Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, card... | 07/29/2008 |
| 7368578 | Five-membered heterocyclic compounds The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom... | 05/06/2008 |
| 7351730 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,... | 04/01/2008 |
| 7348342 | Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of inflammatory diseases. ... | 03/25/2008 |
| 7342039 | Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them. ... | 03/11/2008 |
| 7282412 | Trench semiconductor device having gate oxide layer with multiple thicknesses and processes of fabricating the same The a trench semiconductor device such as a power MOSFET the high electric field at the corner of the trench is diminished by increasing the thickness of the gate oxide layer at the bottom of the trench. Several processes for manufacturing such devices are described... | 10/16/2007 |
| 7279494 | Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of formula I or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions c... | 10/09/2007 |
| 7238568 | Trench semiconductor device having gate oxide layer with multiple thicknesses and processes of fabricating the same The a trench semiconductor device such as a power MOSFET the high electric field at the corner of the trench is diminished by increasing the thickness of the gate oxide layer at the bottom of the trench. Several processes for manufacturing such devices are described... | 07/03/2007 |
| 7238689 | Isoxazoline derivative and herbicide comprising the same as active ingredient An isoxazoline derivative represented by the following general formula [I]: wherein R1 and R2 may be the same or different and are each an alkyl group; R | 07/03/2007 |
| 7235664 | Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, | 06/26/2007 |
| 7205403 | 8-Heteroaryl xanthine adenosine Areceptor antagonists The present invention relates generally to compounds of the formula (I): wherein: X is a five or six-membered heteroaromatic ring, containing one to four heteroatoms, selected f... | 04/17/2007 |
| 7173047 | Benzo (f) insoindol derivatives and their use as ep4 receptor ligands Compounds of formula (I) and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, i... | 02/06/2007 |
| 7166627 | Antibiotic compositions and methods of using the same The present invention relates to a process for the production of substituted 5-isoxazolidinone antibiotics. More specifically the patent relates to the production of compounds that mimic the antibiotic action of β-lactams, are resistant to β-lactamase degradation,... | 01/23/2007 |
| 7160923 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 01/09/2007 |
| 7161006 | Sulphones for inhibition of gamma secretase The invention provides compounds of formula I: which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease. ... | 01/09/2007 |
| 7129259 | Halogenated biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiet... | 10/31/2006 |
| 7125863 | Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t... | 10/24/2006 |
| 7109214 | Substituted cyclopentene compounds The present invention relates to substituted cyclopentene compounds of the general formula I, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use thereof for the production of pharmaceutical preparations.... | 09/19/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7081538 | Substituted isoxazolines and their use as antibacterial agents Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is O, S or NH; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selecte... | 07/25/2006 |
| 7078424 | N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating... | 07/18/2006 |
| 7060710 | Isoxazole pyrazoloindane derivatives as cognition enhancing GABAα5 subtype ligands The present invention provides compounds of formula I: in which: one of X and Y is a nitrogen atom substituted by a group R6′ and the other is a carbon atom substituted by an isoxazole group ... | 06/13/2006 |
| 7052742 | Five membered-ring compounds and utilization thereof in liquid crystal mixtures Fluorinated five-membered ring compounds of the formula (I) R1—X—(A1—M1)a—(A2—M2)b—A3—Y—E (I) where E is a radical T—Z—R2 | 05/30/2006 |
| 7045535 | Compounds useful for inhibiting paramyxovirus neuraminidase Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas: ... | 05/16/2006 |
| 7022725 | Isoxazole derivatives A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic h... | 04/04/2006 |
| 7012088 | Indolone oxazolidinones and derivatives thereof The present invention provides antibacterial agents of formula I described herein and intermediates for their preparation. ... | 03/14/2006 |
| 6974826 | Imidazolidinedione derivatives for the treatment of diabetes and other diseases The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymph... | 12/13/2005 |
| 6946466 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders. | 09/20/2005 |
| 6939886 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor Type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8 | 09/06/2005 |
| 6903216 | Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, | 06/07/2005 |
| 6890942 | Acyl sulfonamides as inhibitors of HIV integrase The present invention relates a series of compounds of Formula I wherein R1, R2, R3, and B are as defined in the specification. The compounds are useful for the inhibition of HIV integr... | 05/10/2005 |
| 6884813 | Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein A is a structure i, ii, iii, or iv X is CR7; Y is ... | 04/26/2005 |
| 6875784 | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for... | 04/05/2005 |
| 6852716 | Substituted-aryl compounds for treatment of disease The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmac... | 02/08/2005 |
| 6841519 | Isoxazoline derivatives and herbicides containing the same as the active ingredient The isoxazoline derivative of the present invention is represented by the following general formula [I]: [wherein Q is a group represented by —S(O)n—(CR5R6)m- (wherein n ... | 01/11/2005 |
| 6828276 | Herbicidally active benzoylcyclohexanediones There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radic... | 12/07/2004 |
| 6825225 | Bicyclic isoxazolinones as antibacterial agents The present invention provides compounds of formula I useful as anti microbial agents wherein X, Y, R1, and n are as defined in thereof. ... | 11/30/2004 |
