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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 7709654 | Process for producing oxazole, imidazole, pyrrazole boryl compounds Process for the preparation of oxazole, imidazole, and pyraxole boryl compounds. The compounds are intermediates to functionalized compounds, both natural and synthetic which are cytotoxic, anticancer and antiviral agents. ... | 05/04/2010 |
| 7662971 | Inhibitors of fatty acid amide hydrolase Improved competitive inhibitors of FAAH employ an α-keto heterocyclic pharmacophore and a binding subunit having a ?-unsaturation. The α-keto heterocyclic pharmacophore and a binding subunit are attached to one another, preferably by a hydrocarbon chain. The impro... | 02/16/2010 |
| 7608721 | Hexafluoroisopropanol derivatives The invention is concerned with novel hexafluoroisopropanol derivatives of formula (I) wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptab... | 10/27/2009 |
| 7544809 | Method for the preparation of oxazoles by condensing aromatic aldehydes with α-ketoximes to form n-oxides and reacting same with activated acid derivatives The present invention is comprised of improved methods in the preparation of oxazoles which results in higher yields with less impurities and contaminants. Oxazoles constitute valuable intermediates in the synthesis of pharmaceutically active substances such as, for... | 06/09/2009 |
| 7521563 | Hydroxamic acid derivative and medicine containing the same as active ingredient A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxam... | 04/21/2009 |
| 7465804 | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an o... | 12/16/2008 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7432293 | Heterocyclic compounds useful as Nurr-1 activators The present invention relates to compounds of formula (I): wherein R1 is hydroxy, C1-4 alkoxy, amino, C1-4 alkyl-amino, di C1-4alkylamino, benzyloxy or C2-C7 alkanoyl, R2 is C1-4 | 10/07/2008 |
| 7429607 | 5-HTreceptor antagonists The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalky... | 09/30/2008 |
| 7429669 | Therapeutic compounds Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed. ... | 09/30/2008 |
| 7427636 | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such comp... | 09/23/2008 |
| 7423058 | Inhibitors of hepatitis C virus NS3 protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 09/09/2008 |
| 7399765 | Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute... | 07/15/2008 |
| 7384964 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (... | 06/10/2008 |
| 7368578 | Five-membered heterocyclic compounds The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom... | 05/06/2008 |
| 7365207 | Process for the production of chiral propionic acid derivatives The present invention is concerned with a novel process for the preparation of compounds of formula I comprising catalytic asymmetric hydrogenation of a compound of formula (II) i... | 04/29/2008 |
| 7365084 | Cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals Provided herein are cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals. ... | 04/29/2008 |
| 7358254 | Method for treating atherosclerosis employing an aP2 inhibitor and combination A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin. ... | 04/15/2008 |
| 7358386 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic d... | 04/15/2008 |
| 7351728 | Oxazolyl-aryloxyacetic acid derivatives and their use as PPAR agonists Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H... | 04/01/2008 |
| 7348349 | Oxazole derivatives The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present ... | 03/25/2008 |
| 7342041 | 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 03/11/2008 |
| 7332514 | Dibenzylamine compound and medicinal use thereof A dibenzylamine compound represented by the formula (1) wherein R1 and R2 are each a C1-6 alkyl group optionally substituted by halogen atoms and the like; R3, R4 ... | 02/19/2008 |
| 7320995 | Benzimidazoles and benzothiazoles as inhibitors of map kinase The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of m... | 01/22/2008 |
| 7320978 | Oxazole derivatives, preparation and therapeutic use thereof This invention relates to compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as described herein. The i... | 01/22/2008 |
| 7319152 | 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators Compounds of formula I or II are provided, wherein R1-R8 are defined herein, and pharmaceutical compositions and kits containing these compounds. Also provided are methods of inducing contraception, providing hormone replacement therapy, treati... | 01/15/2008 |
| 7319104 | hPPARs activators Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseases or conditions associated w... | 01/15/2008 |
| 7314884 | DPP IV inhibitors The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are... | 01/01/2008 |
| 7312211 | Pryanone compounds useful as reversible inhibitors of cysteine proteases Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R2, R3, R4, R6, R8 and Y are defined herein. The compounds are useful for treating autoimmune and othe... | 12/25/2007 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7307095 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides m... | 12/11/2007 |
| 7291622 | Medical uses of carbamate-substituted pyrazolo-pyridine derivatives This invention relates to methods for treating sexual dysfunction, by administering a compound of the formula wherein R1 is H or a di-C1-6-alkylaminocarbonyl radical, and R2 is a ... | 11/06/2007 |
| 7288557 | Triazole derivatives The present invention relates to the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds,... | 10/30/2007 |
| 7279485 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method Substituted heterocyclic derivatives are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)... | 10/09/2007 |
| 7276526 | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands Provided herein are novel substituted thiazoles and oxazoles of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of variou... | 10/02/2007 |
| 7268132 | Substituted thioacetamides The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases. ... | 09/11/2007 |
| 7265170 | Polycarbonate or polyester carbonate containing optical brighteners A thermoplastic molding composition characterized by its optical brightness and good weathering resistance is disclosed. The composition contains a poly(ester) carbonate an optical brightener conforming to ... | 09/04/2007 |
| 7262303 | Process for the production of chiral propionic acid derivatives The present invention is concerned with a novel process for the preparation of compounds of formula I comprising catalytic asymmetric hydrogenation of a compound of formula (II) | 08/28/2007 |
| 7259262 | Arylazole derivatives, their manufacture and use as pharmaceutical agents There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments cont... | 08/21/2007 |
| 7259176 | Process for the preparation of the insulin sensitizer A novel process for the preparation of compounds of formula I and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I and the correspondi... | 08/21/2007 |
