Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 8119813 | Method for preparing enantiomerically enriched -carboxyanhydride This disclosure relates to methods for preparing an enantiomerically enriched N-carboxyanhydride of an amino alpha acid of the formula (IIIa) or (IIIb): from a compound of the formula (IIa) or (IIb), respectively: | 02/21/2012 |
| 8003803 | Fused ring thrombin receptor antagonists Fused-ring, heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an option... | 08/23/2011 |
| 7435751 | 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropy... | 10/14/2008 |
| 7432290 | Inhibitors of IMPDH enzyme The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH e... | 10/07/2008 |
| 7420061 | Process for preparing prodrugs of benzenesulfonamide-containing COX-2 inhibitors Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders. ... | 09/02/2008 |
| 7396847 | Oxazolidinone and/or isoxazoline as antibacterial agents Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, and compounds as shown in (I) wherein C is for example wherein A and... | 07/08/2008 |
| 7378530 | Anti-cancer and anti-microbial 5-membered heterocyclic compounds Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activit... | 05/27/2008 |
| 7368578 | Five-membered heterocyclic compounds The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom... | 05/06/2008 |
| 7342035 | Process for preparing zolmitriptan compounds In particular, zolmitriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and acidification to give hydrazine (III); b) In situ Reaction of the hydrazine hy... | 03/11/2008 |
| 7304050 | Antibacterial agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a... | 12/04/2007 |
| 7273885 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents.... | 09/25/2007 |
| 7265140 | Acyloxymethylcarbamate prodrugs of oxazolidinones The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria. ... | 09/04/2007 |
| 7160912 | Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them. The present invention also relates to a process for t... | 01/09/2007 |
| 7141588 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ... | 11/28/2006 |
| 7129259 | Halogenated biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiet... | 10/31/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 6962936 | Triazole-derived kinase inhibitors and uses thereof Described herein are compounds that are useful as protein kinase inhibitors having the formula: where Ht, R2, T, and m are as described in the specification. The compounds are useful... | 11/08/2005 |
| 6919329 | N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ... | 07/19/2005 |
| 6821994 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a compound of formula (I) (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having a... | 11/23/2004 |
| 6821991 | 2-substituted thiazolidinones as β-3 adrenergic receptor agonists This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 a... | 11/23/2004 |
| 6806369 | Peptide deformylase inhibitors PDF inhibitors and novel methods for their use are provided. ... | 10/19/2004 |
| 6787552 | PPAR delta activators Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient: wherein R1 and R2 each are hydrogen, C1-8 ... | 09/07/2004 |
| 6770664 | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: wherein Y is a radical of Formulae II or III: in which the substituents have the meaning indi... | 08/03/2004 |
| 6759402 | Cyclic felbamate derived compounds The present invention relates to novel felbamate derivatives and their use to treat neurological diseases such as epilepsy and to treat tissue damage resulting form ischemic events. The felbamate derivatives are modified to prevent the formation of metabolites that ... | 07/06/2004 |
| 6747104 | Azlactone photoiniferters for radical polymerization Photoiniferters for controlled radical polymerizations are described. The photoiniferters have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers. ... | 06/08/2004 |
| 6605631 | Ortho-substituted 2-methoxyiminophenyl-N-methylacetamides Compounds of the general formula I ##STR1## where the index and the substituents have the following meanings: n is 0 or 1 to 4; X is O or S; Y is a five-membered heteroaromatic ring; R1 is nitro; cyano; halogen; alkyl; haloalkyl; alkoxy; haloalkoxy; alky... | 08/12/2003 |
| 6589969 | Carboxylic acid derivatives and drugs containing the same as the active ingredient A peroxisome proliferator activated receptor regulator containing a compound of formula (I) ##STR1## (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compo... | 07/08/2003 |
| 6562816 | Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease The invention provides compounds of Formula I: compounds of the Formula I: ##STR1## wherein R1, R2, R4, R6, X, and W are defined herein. These compounds may be in the form of pharmaceutical salts or compositions... | 05/13/2003 |
| 6545154 | Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products The invention relates to a process for preparing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides in which, in a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonyl halides in the presence of an acid acceptor and in the presence of a ... | 04/08/2003 |
| 6538142 | Process for the preparation of metaxalone A process for the preparation of 5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone, which includes: a) reacting 3,5-dimethylphonel with epichlorohydrin to obtain a mixture of 1-(3,5-dimethylphenoxy)2,3-epoxy propane (1) and 1-(3,5-dimethylphenoxy)-3-chloro-2-... | 03/25/2003 |
| 6528535 | Bicyclic inhibitors of protein farnesyl transferase The present invention provide compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable... | 03/04/2003 |
| 6506905 | Method of preparation of paclitaxel (taxol) using 3-(alk-2-ynyloxy) carbonyl-5-oxazolidine carboxylic acid 3-(alk-2-ynyloxy)carbonyl-5-oxazolidine carboxylic acid and its analogs having a formula ##STR1## and wherein R1 is hydrogen, aryl, heteroaryl, alkyl, alkenyl, alkynyl, R2 and R3 are independently selected from hydrogen, a... | 01/14/2003 |
| 6479514 | Quinoline-aminomethyl-pyridyl derivatives with anti-helicobacter activity Compounds of formula (I) in which the substituents and symbols have the meanings indicated in the description, are suitable for the control of Helicobacter bacteria. ##STR1##... | 11/12/2002 |
| 6476202 | 5-acylamino-2-arylazo, nitro, or nitroso-4-substituted-phenol compounds and method of using them Disclosed is a 5-acylamino-2-arylazo, nitro, or nitroso-4-substituted-phenol having the structural formula I: ##STR1## wherein: R* is an arylazo, nitro, or nitroso group, Y is a coupling-off group, and R' is a substituent group. Also disclosed is a method of u... | 11/05/2002 |
| 6448286 | Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.... | 09/10/2002 |
| 6441013 | Sulphonyloxazolamines as therapeutic active ingredients The present invention relates to sulphonylexazolamines of general formula (I), wherein R1, R2 represent independently from each other H, A, --(CH2)n --Ar or alkenyl with 2-6 C atoms, R1 and R2 | 08/27/2002 |
| 6436967 | Process for preparing prodrugs of benzenesulfonamide-containing cox-2 inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to prodrugs of compounds which selectively inhibit cyclooxygenase-2. The use of non-steroidal antiinflammatory drugs (NSAIDs) in treating pain and the swelli... | 08/20/2002 |
| 6420613 | Process for preparing reductants of unsaturated organic compounds by the use of trichlorosilane and reducing agents A method of preparing a reduced product by efficiently reducing an unsaturated organic compound by using, as a reducing agent, a trichlorosilane which is industrially cheaply available and is easy to handle, and a reducing agent therefor. A reduced produc... | 07/16/2002 |
| 6399774 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 06/04/2002 |
| 6395724 | Multibinding inhibitors of cyclooxygenase-2 Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently ... | 05/28/2002 |
