Did You Know...
...that on Dec. 15, 1836, the Patent Office was completely destroyed by fire? Lost were some 7,000 models, 9,000 drawings, and 230 books plus all records of patent applications and grants.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8143416 | Alternative synthesis of renin inhibitors and intermediates thereof The present invention relates to synthetic routes to prepare a compound of the formula wherein R1 is halogen, C1-6halogenalkyl, C1-6alkoxy-C1-6alkyloxy or C1-6alkoxy-C | 03/27/2012 |
| 8093399 | Benzoxazole derivative, and light-emitting element, light-emitting device, and electronic device using benzoxazole derivative Disclosed is a novel benzoxazole derivative which has high excitation energy, particularly high triplet excitation energy, and is a bipolar substance. A benzoxazole derivative represented by the following General Formula (G1) is provided. | 01/10/2012 |
| 7642358 | Substituted phenylacetic acids Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion. ... | 01/05/2010 |
| 7579478 | Process for the purification of substituted benzoxazole compounds The present invention provides processes for the purification of substituted benzoxazole compounds, and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol. The processes include recrystallizing the compound from a solution comprising acetone and ac... | 08/25/2009 |
| 7414138 | Benzoxazole and benzodiazole UV-A sunscreens The present invention relates to 1,3-benzoxazole or benzodiazole UV-A sunscreens and to compositions, in particular topical compositions, containing the above UV-A sunscreens. ... | 08/19/2008 |
| 7384965 | Fused heterocyclic derivatives as PPAR modulators The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U ia an aliphatic linker; (c) Y is selected from the gr... | 06/10/2008 |
| 7307094 | Benzoxazole carboxamides for treating CINV and IBS-D Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D. | 12/11/2007 |
| 7294643 | UK-1 analogues: methods of preparation and use The present invention includes a number of structural analogues of UK-1. A comparision of the anticancer activity of the UK-1 analogues with their ability to inhibit the growth of methicillin-sensitive and methicillin-resistant Staphylococcus aureus demonstra... | 11/13/2007 |
| 7276627 | One pot sequential reactions and novel products produced thereby A method for producing sequenced reaction products comprising performing, in one pot, a first reaction at a lower temperature followed by a second reaction at a higher temperature in the presence of a catalyst system comprising a proazaphosphatrane in combination wi... | 10/02/2007 |
| 7253154 | Substituted thiazolopyrimidines as xanthine oxidase inhibitors The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which m... | 08/07/2007 |
| 7214696 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective... | 05/08/2007 |
| 7214695 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective... | 05/08/2007 |
| 7148247 | Substituted benzoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as def... | 12/12/2006 |
| 7144893 | 4-aryl quinols and analogs thereof as therapeutic agents The present invention pertains to compounds of the formula (1) which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitor: wherein: Q is ═O or ═N—S(... | 12/05/2006 |
| 6967251 | Reagents for labeling biomolecules having aldehyde or ketone moieties Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. In one embodiment is provided reagents that have the following formula: | 11/22/2005 |
| 6960607 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, and R4, and X as defined in the specification, or a p... | 11/01/2005 |
| 6887877 | Compounds and methods for the treatment or prevention of Flavivirus infections The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating Flaviviridae viral infection. ... | 05/03/2005 |
| 6867227 | Compounds that exhibit specific molecular recognition of mixed nucleic acid sequences and bind the DNA minor groove as a dimer Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been... | 03/15/2005 |
| 6861533 | Solution phase sythesis of arylbenzoxazoles This invention provides methods for the solution-phase synthesis of arylbenzoxazoles. The methods involve condensation of aminophenols with benzaldehydes to form a Schiff base. The Schiff base is then induced to undergo oxidative cyclization in the presence of DDQ. ... | 03/01/2005 |
| 6800380 | Organometallic luminescent materials and organic electroluminescent device containing same An organometallic luminescent material comprising the compound of formula (I) of the present invention can emit pure blue light and have high thermal stability: wherein, M1 is a monovalent or tetravalen... | 10/05/2004 |
| 6794403 | Substituted benzoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in t... | 09/21/2004 |
| 6777410 | Isoindole derivatives This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 ... | 08/17/2004 |
| 6737431 | Benzoxazole derivatives as novel melatonergic agents Novel benzoxazole derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents. ... | 05/18/2004 |
| 6706744 | Glucagon antagonists/inverse agonists Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein... | 03/16/2004 |
| 6608098 | Isoindole derivatives This invention relates to compounds represented by the general formula [I] ##STR1## wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are th... | 08/19/2003 |
| 6451988 | Naphthol derivatives Novel naphthol derivatives, and various azo compounds and metal complexes prepared by using the derivatives are provided. The instant invention provides naphthol derivatives represented by general formula (1); ##STR1## wherein at least one of Y1 | 09/17/2002 |
| 6417213 | Tricyclic compound, their production and use A compound of the formula ##STR1## wherein R1 is H or a substituent; m is 1-3; Ar is an aromatic group which may be substituted; X is a bond or a divalent straight-chain group having 1-6 atoms which may be substituted; Y is --S--, --O--, or ... | 07/09/2002 |
| 6376485 | Benzoxazoles with PDE-inhibiting activity Compounds of formula I ##STR1## in which R1, R2, R3 and A have the meaning set forth in the specification, are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors useful as therapeutics in human and veterinary medicine. They are distinguished ... | 04/23/2002 |
| 6352958 | Cycloimido-substituted benzofused heterocyclic herbicides Novel herbicidal compounds, compositions containing them, and methods for their use in controlling weeds are disclosed. The novel herbicidal compounds are represented by formula I: ##STR1## where J is a 1-substituted-6-trifluoromethyl-2,4-pyrimidinedione-... | 03/05/2002 |
| 6251689 | Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of com... | 06/26/2001 |
| 6222044 | Process for making 2-aryl benz (ox, thi, imid) azoles and 2-aminoaryl aminobenz (ox, thi, imid) azoles 2-(aryl)-benz(ox, thi, imid)azoles are prepared by reacting an aromatic aldehyde with hydroxylamine to form an aromatic aldehyde oxime, halogenating the oxime to form an aromatic hydroxamoyl halide, and then reacting this halide with certain aromatic amin... | 04/24/2001 |
| 6177572 | Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.... | 01/23/2001 |
| 6166216 | Compounds useful as neuro-protective agents This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.... | 12/26/2000 |
| 6100405 | Benzothiazole-containing two-photon chromophores exhibiting strong frequency upconversion There are provided asymmetrical two-photon chromophores of the formula: D--Ar--A wherein Ar is selected from the group consisting of ##STR1## wherein Fl is a fluorene group of the formula: ##STR2## wherein R1 and R2 are alkyl gr... | 08/08/2000 |
| 6048631 | Organic electroluminescence device and organic electroluminescence device material An object of this invention is to provide an organic EL device material stable against heat, having a high purity in bluish light emission and a high efficiency. The organic EL device comprises a glass substrate, a transparent anode, a TPD which is an ele... | 04/11/2000 |
| 6015827 | Benzoxazole-4-carboxamides and their use in inhibiting poly (adp-ribose) polymerase activity and improving cytotoxic effectiveness of cytotoxic drugs or radiotherapy Benzoxazole carboxamides are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damagin... | 01/18/2000 |
| 5952515 | Diaryl-2h-napthopyrans The description concerns a photochromicsubstance, with a diaryl-2H-naphthopyrane having a link in the form Y--Ar, Z--Ar, Y--Ar--Y, Y--Ar--Y', Y--Ar--Z, Z--Ar--Z or Z--Ar--Z', in which Y, Y', Z and Z' are pyranes. The photochromic substance is also disting... | 09/14/1999 |
| 5925759 | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive int... | 07/20/1999 |
| 5883259 | Benzoxazole based nonlinear optical derivatives and polymers obtained therefrom The present invention provides benzoxazole derivatives and nonlinear optical (NLO) materials obtained therefrom as a novel organic NLO material having following general formula (I), which can be used as optical devices such as electro-optic modulator, opt... | 03/16/1999 |
| 5783590 | 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenzCD!indoles 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenzcd!indoles are provided which are useful in modifying the function of serotonin in mammals.... | 07/21/1998 |
