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| Number | Title | Issue Date |
| 7790903 | Process for production of optically active PPAR-activating compound and intermediate of the same A process for obtaining a compound (1) and an intermediate thereof in high yield and high optical yield is provided. A process for producing a compound (4), the process including reacting a compound (2) with a compound (3) in the presence of a base; and a pro... | 09/07/2010 |
| 7714141 | Processes for production of optically active PPAR-activating compounds and intermediates for production thereof The invention provides a process for producing an optically active butyric acid compound and a production intermediate therefore at high yield and high purity. The present invention provides a process for producing Compound (6), including reacting Compound (1... | 05/11/2010 |
| 7414046 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also re... | 08/19/2008 |
| RE40245 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates ... | 04/15/2008 |
| 7312338 | 3-phenylpropionic acid derivatives The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1-C4-alkyl group; Y represents NH, N—C1-C10-alkyl, O, or S; Z... | 12/25/2007 |
| 7300966 | Method for producing blends of phthalic acid diesters, decanols and tridecanols A process is described for preparing mixtures of diesters of phthalic acid with decanols and tridecanols by reacting phthalic acid or a reactive derivative of phthalic acid with a mixture made from at least one decanol and at least one tridecanol. Mixtures ob... | 11/27/2007 |
| 7301033 | PPAR-activating compound The present invention provides a compound selectively activating PPARα, which is useful as a medicament. The present invention is specifically directed to a benzoic acid derivative represented by the following general formula (1): | 11/27/2007 |
| 7285566 | Resistance-repellent retroviral protease inhibitors Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided. ... | 10/23/2007 |
| 7282498 | Substituted fused pyrroleoximes and fused pyrazoleoximes Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, ant... | 10/16/2007 |
| 7265130 | NPY Y5 antagonist The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, ... | 09/04/2007 |
| 7244752 | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are ... | 07/17/2007 |
| 7166616 | Substituted alkanoic acids The invention is directed to physiologically active compounds of general formula (I): wherein: represents (i) a saturated 3 to 6 membered carbocycle, optiona... | 01/23/2007 |
| 7125893 | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I in which R1a, R1b, R2a, R3a, R3b, R4, R... | 10/24/2006 |
| 7109226 | PPAR-activating compound and pharmaceutical composition comprising the compound A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPARα. ... | 09/19/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 6995181 | Modulators of the glucocorticoid receptor and method Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the s... | 02/07/2006 |
| 6992083 | Benzoxazol derivatives The invention relates to compounds of formula wherein R is phenyl, unsubstituted or substituted by halogen or —CH2N(CH3)(CH2)nOCH3 | 01/31/2006 |
| 6905856 | Soluble GlcNAc phosphotransferase The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same. ... | 06/14/2005 |
| 6812237 | N-substituted peptidyl nitriles as cysteine cathepsin inhibitors Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in ... | 11/02/2004 |
| 6800486 | Method for quantitative determination of amino acids A novel method for the determination of amino acids by HPLC using pre-column derivatization is described. In this procedure, the aminno acids are derivatized with 2-chlorobenzoxazole to yield highly fluroresent N-(2-benzoxazolyl)-amino acids (BOX-AAs) for detection ... | 10/05/2004 |
| 6787651 | Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-γ binding agents Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-γ mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis. ... | 09/07/2004 |
| 6784199 | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, isoxazolidine compounds which have ... | 08/31/2004 |
| 6660858 | 2-aminobenzoxazole derivatives and combinatorial libraries thereof The present invention relates to novel 2-aminobenzoxazole derivative compounds of the following formula: ##STR1## wherein R1 to R4 and Z have the meanings provided herein. The invention further relates to combinatorial libraries cont... | 12/09/2003 |
| 6653334 | Benzoxazole compound and pharmaceutical composition containing the same The present invention is directed to a benzoxazole compound represented by the following formula (1): ##STR1## (wherein R1 represents an alkyl group, a C6-10 aryl-C1-8 alkyl group, etc.; each of R2 and R3 | 11/25/2003 |
| 6632809 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: ##STR1## or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for tr... | 10/14/2003 |
| 6630470 | G-CSF mimetics Invented are G-CSF mimetics. Also invented are selected octacyclic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds as G-CSF mimetics. Also invented are novel processes used in preparing these compoun... | 10/07/2003 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6593354 | Substituted benzoxazole compounds The invention is directed to physiologically active compounds of formula (Ia): ##STR1## wherein R1 is optionally substituted aryl or optionally substituted heteroaryl; R2 is hydrogen, halogen, lower alkyl or lower alkoxy; R... | 07/15/2003 |
| 6562851 | Substituted bicyclic compounds The invention is directed to physiologically active compounds of general formula (I): ##STR1## wherein Het is an optionally substituted, saturated, partially saturated or fully unsaturated 8 to 10 membered bicyclic ring system containing at least one... | 05/13/2003 |
| 6541423 | 4-(3',4'-heterocyclyl benzoyl) pyrazoles as herbicidal agents The invention relates to pyrazolyl derivatives of benzo-condensated, unsaturated 5-membered nitrogen heterocycles of the general formula (I), wherein X represents N or a group C--R3 ; Y is O, S, SO, SO2 or NR4 or X--Y is S... | 04/01/2003 |
| 6541497 | Hypoglycemic and hypolipidemic compounds This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.... | 04/01/2003 |
| 6518291 | Inhibitors of IMPDH enzyme The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly... | 02/11/2003 |
| 6486187 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6 alkyl or aryl; ... | 11/26/2002 |
| 6482951 | Isoindolin-1-one glucokinase activators Isoindolin-1-one-substituted propionamide glucokinase activators which increase insulin secretion in the treatment of type II diabetes.... | 11/19/2002 |
| 6451792 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.... | 09/17/2002 |
| 6441184 | Fused heteroaromatic glucokinase activators Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.... | 08/27/2002 |
| 6441012 | Chemical compounds ##STR1## Compound of formula (I) wherein: A is a bicyclic heteroaryl, optionally substituted with one or more substituents; B is linker group connecting group A to group D and comprising a 3 or 4 atom linker where each atom is independently selected from ... | 08/27/2002 |
| 6433188 | Fused heteroaromatic glucokinase activators Glucokinase activating amides as herein disclosed are useful for increasing insulin secretion in the treatment of type II diabetes.... | 08/13/2002 |
| 6417213 | Tricyclic compound, their production and use A compound of the formula ##STR1## wherein R1 is H or a substituent; m is 1-3; Ar is an aromatic group which may be substituted; X is a bond or a divalent straight-chain group having 1-6 atoms which may be substituted; Y is --S--, --O--, or ... | 07/09/2002 |
| 6372736 | Heterocyclic compounds as inhibitors of rotamase enzymes Compounds of the formula (I): ##STR1## wherein A, Y, R, X, R1, R2, R3 and R4 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal r... | 04/16/2002 |
