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| Number | Title | Issue Date |
| 8129541 | 5-phenylthiazole derivatives and use as PI3 kinase inhibitors Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediate... | 03/06/2012 |
| 8049016 | Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also ... | 11/01/2011 |
| 7999114 | Dicycloalkylcarbamoyl ureas as glucokinase activators This invention relates to dicycloalkylcarbamoyl ureas of formula (I), which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. | 08/16/2011 |
| 7902375 | 5-phenyl-4-methyl-thiazol-2-yl-amine derivatives as inhibitors of phosphatidylin ositol 3 kinase enzymes (PI13) for treatment of inflammatory diseases in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by... | 03/08/2011 |
| 7384967 | Aryl carbonyl derivatives as therapeutic agents This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. ... | 06/10/2008 |
| 7183300 | Inhibitors of HIV-1 capsid formation: substituted aryl aminomethyl thiazole ureas and analogues thereof Substituted aryl aminomethyl thiazole ureas and analogues thereof that act as inhibitors of viral capsid formation, including HIV capsid formation, are provided here. Generally the virus capsid formation inhibitors described herein are compounds of Formula I ... | 02/27/2007 |
| 7087599 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 08/08/2006 |
| 7060718 | Arylsulfonanilide ureas The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particular... | 06/13/2006 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6960605 | Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging Provided are, among other things, compounds of formula I or IA, Also provided are methods of treatment with such compounds. ... | 11/01/2005 |
| 6960664 | Aza hydroxylated ethyl amine compounds Disclosed are compounds of formula: and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R... | 11/01/2005 |
| 6960606 | Adamantyl Thiazole Thioureas Novel aromatic and heterocyclic thiazolyl thiourea compounds, pharameutical compositions including such, and methods for their use are disclosed. The compounds are effective agents for the treatment of HIV infection, including non-nucleoside inhibitor-resistant, and... | 11/01/2005 |
| 6863647 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents Compounds which are 2-ureido-1,3-thiazole derivatives of formula (I) wherein R is a halogen atom, a nitro group, an optionally substituted amino group or it is a group optionally further substituted, selected from: i) straight or branched C1-C6 | 03/08/2005 |
| 6720427 | Thiazole derivatives The invention provides compounds of formula 1 wherein R1, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inh... | 04/13/2004 |
| 6706735 | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 03/16/2004 |
| 6686363 | Cyclopropyl containing oxazolidinone antibiotics and derivatives thereof This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as... | 02/03/2004 |
| 6686476 | Substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents Antiatherosclerotic agents are provided which are represented by Formulas I or II: ##STR1## wherein R is ##STR2## wherein R9, R10, R11, R12, R13, and R14 are each, independently, hydro... | 02/03/2004 |
| 6660732 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 12/09/2003 |
| 6656933 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 12/02/2003 |
| 6583165 | Arylsulfonanilide ureas The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,... | 06/24/2003 |
| 6559168 | Thiazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the for... | 05/06/2003 |
| 6545152 | R-isomers of nonnucleoside inhibitors Novel chiral derivitaves of non-nucleoside inhibitors (NNI), particularly R-isomers of halopyridyl and thiazoyl thiourea compounds are provided as potent inhibitors of reverse transcriptase (RT), and particularly of retroviral RT, most particularly HIV RT... | 04/08/2003 |
| 6509363 | Heterocyclic inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides... | 01/21/2003 |
| 6448286 | Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.... | 09/10/2002 |
| 6358945 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 03/19/2002 |
| 6355672 | Benzothiepin derivatives, process for the preparation of the same and uses thereof The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/12/2002 |
| 6320054 | Thiazole derivatives Compounds of the formula: ##STR1## as well as pharmaceutically usable salts and esters thereof, wherein R1, R2 and R3 have the significance ascribed herein, inhibit binding of adhesive proteins to the surface of different ... | 11/20/2001 |
| 6316503 | LXR modulators The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The compounds and compo... | 11/13/2001 |
| 6313305 | Cephalosporins A compound having the formula selected from the group consisting of ##STR1## wherein either R3p and R4p are identical and selected from the group consisting of --OH, protected --OH and acyloxy of 1 to 8 carbon atoms, R2p i... | 11/06/2001 |
| 6297266 | Thiazole derivatives Compounds of formula (I) ##STR1## as well as pharmaceutically usable salts and esters thereof, wherein R1, R2 and R3 have the significance described in the specification, inhibit the binding of adhesive proteins to the sur... | 10/02/2001 |
| 6187799 | Inhibition of raf kinase activity using aryl ureas Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.... | 02/13/2001 |
| 6172260 | Preparation of high dye-yield couplers and intermediates useful therein Disclosed is a carbamyl chloride of an aminoarylcarbonyl compound having the structural formula I: ##STR1## wherein R is an alkyl, alkenyl, or aryl group; A is an aryl (including heteroaryl) ring group; each R' is independently an alkyl group which may form a ... | 01/09/2001 |
| 6165943 | Thiazolimine derivatives Thiazolimine derivatives of the formula I ##STR1## where: X and Y independently of one another are each hydrogen, halogen, C1 -C4 -alkyl, C1 -C4 -haloalkyl; Z is hydrogen; Cl -C8 -alkyl, C | 12/26/2000 |
| 6117894 | Acid stabilized pharmaceutical compositions of tizoxanide and nitazoxanide The present invention relates to a pharmaceutical composition containing as active agent, solid particles of a compound selected from the group consisting of: compound of formula I: ##STR1## compound of formula II: ##STR2## and mixtures the... | 09/12/2000 |
| 6096898 | One pot synthesis of 1,2,4-triazoles One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.... | 08/01/2000 |
| 6057349 | 2-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides and ureas and their use The present invention concerns novel compounds represented by the Formula: ##STR1## wherein: A is R1q (R3 R60 N)m (Z)(NR2)n ; m and q are each 0 or 1, with the proviso that when ... | 05/02/2000 |
| 6048884 | Amide derivatives and medicinal compositions thereof An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle. ##STR1## (The symbols in the formula have the following... | 04/11/2000 |
| 6022497 | Photochromic six-membered heterocyclic-fused naphthopyrans Described are novel photochromic six-membered heterocyclic-fused naphthopyran compounds, examples of which are naphthopyran compounds having a substituted or unsubstituted six-membered heterocyclic group fused to one side of the naphtho portion of the nap... | 02/08/2000 |
| 6004963 | Substituted 2, 4-imidazolidinedione compounds as pharmaceutical active ingredients A substituted 2,4-imidazolidinedione compound corresponding to the formula I ##STR1## a process for production thereof and the use of these compounds in a pharmaceutical preparation are described. Substituents R1, R2, R3 and R4 have the same mea... | 12/21/1999 |
| 5998410 | Sulfonamide derivatives A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.... | 12/07/1999 |
