Class 548/194 - The chalcogen, X, is in a -C(=X)- group

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the chalcogen, X (i.e., oxygen, sulfur,
No. of patents: 385
Last issue date: 12/20/2011

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Number	Title	Issue Date
8080668	Thiazoles derivatives as AMPK activator The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5′-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds. ...	12/20/2011
7982049	α-form or β-form crystal of acetanilide derivative To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide. The α-form cryst...	07/19/2011
7838681	Synthesis of substituted heterocyclic compounds The invention relates to a method of synthesizing heterocyclic compounds. The invention is characterised in that it consists in opening a compound having formula (I), wherein: —X represents NH, O, S or a N-p group, p being a protective group, such as Boc or Troc; ...	11/23/2010
7696354	Cephem compounds having broad antibacterial spectrum A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substitut...	04/13/2010
7655804	Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of...	02/02/2010
7652146	Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors The invention is directed to processes for preparing 2-aminothiazole-5-carboxamides of formula I wherein R1, R2, R3, R4 and R5 are as defined a...	01/26/2010
7427635	Substituted hydantoins The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, ...	09/23/2008
7423055	2-(3-Aminoaryl)amino-4-aryl-thiazoles for the treatment of diseases The present invention relates to novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human an...	09/09/2008
7423156	Preparation and use of aryl alkyl acid derivatives for the treatment of obesity This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ...	09/09/2008
7414067	Ophthalmic compositions for treating ocular hypertension This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such co...	08/19/2008
7408069	Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives A method for preparing a compound of the structure I, ...	08/05/2008
7384928	Broad spectrum cephem compounds A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substitut...	06/10/2008
7384968	Thiazole-amine compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R3, R4, R5, R6 and R7 are as defined. Compounds of the Formula I have activity inhibi...	06/10/2008
7358267	Bis-aryl thiazole derivatives Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject c...	04/15/2008
7342117	α-form or β-form crystal of acetanilide derivative To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenyleth-yl)amino]ethyl]acetanilide. The α-form crys...	03/11/2008
7309791	3-phenylpropionic acid derivatives The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1–C4-alkyl group; Y represents NH, N—C1–C10-alkyl, O, or ...	12/18/2007
7291744	N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity The present application describes modulators of chemokine receptors of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ...	11/06/2007
7265109	Thiazole derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents have the significance given in the specification, and the compounds are neuropeptide Y(NPY) antagon...	09/04/2007
7253197	Aminothiazole derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4 have the significance given in the specification, and the compounds, salts and esters...	08/07/2007
7250431	Thiazole derivatives Thiazole derivatives of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, a and b have the significance given in the specification. Th...	07/31/2007
7250508	Cefdinir intermediate 7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula I in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. I...	07/31/2007
7244842	Amorphous hydrate of a cephalosporin antibiotic A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a terti...	07/17/2007
7244278	Agent and method for oxidative coloring of keratin fibers The object of the present invention is a ready-to-use agent for coloring keratin fibers containing (i) at least one heterocyclic hydrazone derivative of formula (I), (ii) at least one aromatic enamine of formula (IIa) or an acid addition compound thereof (IIb) and (...	07/17/2007
7232838	2-amino-4,5-trisubstituted thiazolyl derivatives This invention concerns the use of a compound of formula (I′), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C1-6alkyl; C1-6alkylcarbonyl; C1-6...	06/19/2007
7179827	Thiazoles and methods of their use This invention concerns novel thiazole compounds. Methods of using these compounds for the treatment, prevention and management of various diseases or disorders, as well as pharmaceutical compositions of these compounds, are also disclosed. ...	02/20/2007
7173137	Epothilone analogs Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancers agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of micro...	02/06/2007
7173129	Sulfonamide-substituted chalcone derivatives and their use to treat diseases The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the ...	02/06/2007
7163952	Azole compound and medicinal use thereof The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR7, —X1-A1-COOR7 (R7 is H, alkyl) or tetr...	01/16/2007
7145017	Preparation of Aztreonam The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3α(Z),4β]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreona...	12/05/2006
7138403	2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity This invention concerns the use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C1-6	11/21/2006
7125900	Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which act...	10/24/2006
7105564	Pharmaceutical composition comprising a dual antagonist against PGD/TXAreceptors having a [2.2.1] or [3.1.1] bicyclic skeleton The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D2 receptor and pharmaceutical compositions comprising them. A compound of the formula (I):	09/12/2006
7105659	Process for preparing cefdinir The present invention relates to a novel process for the preparation of a cefdinir by reacting O-acetyl thioester of Formula I with ...	09/12/2006
7091228	Preparation and use of aryl alkyl acid derivatives for the treatment of obesity This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ...	08/15/2006
7074794	Proline derivatives and the use thereof as drugs The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position...	07/11/2006
7067553	Thiourea compounds and the pharmaceutical compositions containing the same The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as an antagonist against vanilloid receptor (VR) and the pharmaceutical compositions thereof. As diseases assoc...	06/27/2006
7012143	Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines The present invention relates to novel cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are poten...	03/14/2006
6984735	Process for making an aldehyde A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a ...	01/10/2006
6974830	NR1H4 nuclear receptor binding compounds The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear re...	12/13/2005
6972297	2-Hydroxy-mutilin carbamate derivatives for antibacterial use 2-(S)-hydroxymutilin carbamate derivatives of formula (I), in which R1 is a 5- or 6-membered optionally substituted heteroaryl group; and R2 is vinyl or ethyl, are useful in the treatment of bacterial infections	12/06/2005

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Class 548/194 - The chalcogen, X, is in a -C(=X)- group