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Class 548/193 - Chalcogen attached indirectly to the thiazole ring by nonionic bonding


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium,
No. of patents: 250
Last issue date: 09/23/2008


1              
NumberTitleIssue Date
7427635Substituted hydantoins
The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, ...
09/23/2008
7414067Ophthalmic compositions for treating ocular hypertension
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such co...
08/19/2008
7408069Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives
A method for preparing a compound of the structure I, ...
08/05/2008
7384968Thiazole-amine compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula I wherein R1, R3, R4, R5, R6 and R7 are as defined. Compounds of the Formula I have activity inhibi...
06/10/2008
7381736Thiazole and thiadiazole inhibitors of tyrosine phosphatases
Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B. ...
06/03/2008
7285567Halogenated benzamide derivatives
A halogenated benzamide derivative characterized by greater specificity for viral pathogens and less disruptive to beneficial gut microflora, according to formula (III): in which ...
10/23/2007
7205291Carbapenem compounds
A compound or its pharmaceutically acceptable salt represented by the following formula: The invention is a carbapenem compound which has a potent antibacterial activity over a broad range of Gram negative and Gr...
04/17/2007
RE39140Heterocyclic compounds
Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by...
06/20/2006
RE39131Heterocyclic compounds
Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atoms or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted b...
06/13/2006
RE39127Heterocyclic compounds
Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by...
06/13/2006
RE39129Heterocyclic compounds
Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by...
06/13/2006
RE39130Heterocyclic compounds
Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by...
06/13/2006
6974830NR1H4 nuclear receptor binding compounds
The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear re...
12/13/2005
6960664Aza hydroxylated ethyl amine compounds
Disclosed are compounds of formula: and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R...
11/01/2005
6949536Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ...
09/27/2005
6727238Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi...
04/27/2004
6720427Thiazole derivatives
The invention provides compounds of formula 1 wherein R1, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inh...
04/13/2004
6706920Antistatic composition
An antistatic composition comprises (a) at least one ionic salt consisting of a nonpolymeric nitrogen onium cation and a weakly coordinating fluoroorganic anion, the conjugate acid of the anion being a superacid; and (b) at least one thermoplastic polymer. The compo...
03/16/2004
6706747Conformationally rigid bicyclic and adamantane derivatives useful as α2-adrenergic blocking agents
A compound of formula I in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; ...
03/16/2004
66998952-aminothiazoline derivatives and process for preparing the same
The present invention relates to a class of 2-aminothiazoline derivatives of formula I: ##STR1## in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, --CH2 --R3, --C...
03/02/2004
6677353Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating...
01/13/2004
6677341(R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and m...
01/13/2004
6670376Aryl aniline 댢 adrenergic receptor agonists
The invention provides novel 댢 adrenergic receptor agonist compounds of formula (I): ##STR1## wherein R1 -R13 and w have any of the values described in the specification. The invention also provides pharmaceutic...
12/30/2003
6586433Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating...
07/01/2003
6586456Aminothiazole derivatives and their use as CRF receptor ligands
Substituted 4-phenyl-2-aminothiazole derivatives, processes for preparing the same, and the use thereof as corticotropin releasing factor (CRF) antagonists....
07/01/2003
6531497Epothilone derivatives and their synthesis and use
The invention relates to epothilone analog represented by formula (I) wherein (i) R2 is absent or oxygen; "a" can be either a single or double bond; "b" can be either absent or a single bond; and "c" can be either absent or a single bond, with ...
03/11/2003
6458803Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating...
10/01/2002
6448286Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors
The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors....
09/10/2002
6348482Catechols as antimicrobial agents
Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: ##STR1## wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino...
02/19/2002
6319935Conformationally rigid bicyclic and adamantane derivatives useful as 댒-adrenergic blocking agents
A compound of formula I ##STR1## in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or ...
11/20/2001
6307090Acylated oligopeptide derivatives having cell signal inhibiting activity
The invention relates to an acylated peptide, namely a compound of formula (I), ##STR1## wherein n is 0 to 15, X is oxalyl PTI is the bivalent radical of tyrosine or (preferably) the bivalent radical of phosphotyrosine or a phosphotyrosine mimetic, AA sta...
10/23/2001
6300357Triazole antifungal agent
A triazole compound having the formula: ##STR1## wherein Ar1 represents a phenyl group which may be substituted, Ar2 represents a heterocyclic group which may be substituted, R0 represents a hydrogen atom or a lower alkyl;...
10/09/2001
6265553Intermediate thiazoles and process for the preparation of 2-chloro-5-chloromethyl-thiazole
The present invention relates to intermediate thiazole compounds and a process for preparing 2-chloro-5-chloromethylthiazole which is a known compound useful for the preparation of insecticides....
07/24/2001
6187802Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use
Compounds of Formula I ##STR1## including pharmaceutically acceptable salts thereof in the form of individual enantiomers, racemates, or other mixtures of enantiomers, in which Ar is phenyl, naphthyl or benzo[b]thiophenyl, each of which may be option...
02/13/2001
6165943Thiazolimine derivatives
Thiazolimine derivatives of the formula I ##STR1## where: X and Y independently of one another are each hydrogen, halogen, C1 -C4 -alkyl, C1 -C4 -haloalkyl; Z is hydrogen; Cl -C8 -alkyl, C
12/26/2000
6107487Methine and azamethine dyes based on 5-membered heterocycles with a trifluoromethyl group
Dyes of the formula Q-X=Het where X is nitrogen or CH, Q is a 5- or 6-membered carbocyclic or heterocyclic radical and Het is a radical of the formula ##STR1## where Y is oxygen, sulfur, imino, C1 -C4 -alkylimino, substituted o...
08/22/2000
6096898One pot synthesis of 1,2,4-triazoles
One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent....
08/01/2000
6080772Thiazole compounds and methods of modulating signal transduction
The present invention relates to thiazole containing compounds capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such compounds to modulate or regulate signal transduction by inhibiting protein tyrosi...
06/27/2000
6057451Anti-herpesvirus compounds and methods for identifying, making and using same
This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes h...
05/02/2000
60573492-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides and ureas and their use
The present invention concerns novel compounds represented by the Formula: ##STR1## wherein: A is R1q (R3 R60 N)m (Z)(NR2)n ; m and q are each 0 or 1, with the proviso that when ...
05/02/2000
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