...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 7427635 | Substituted hydantoins The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, ... | 09/23/2008 |
| 7414067 | Ophthalmic compositions for treating ocular hypertension This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such co... | 08/19/2008 |
| 7408069 | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives A method for preparing a compound of the structure I, ... | 08/05/2008 |
| 7384968 | Thiazole-amine compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R3, R4, R5, R6 and R7 are as defined. Compounds of the Formula I have activity inhibi... | 06/10/2008 |
| 7381736 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B. ... | 06/03/2008 |
| 7285567 | Halogenated benzamide derivatives A halogenated benzamide derivative characterized by greater specificity for viral pathogens and less disruptive to beneficial gut microflora, according to formula (III): in which ... | 10/23/2007 |
| 7205291 | Carbapenem compounds A compound or its pharmaceutically acceptable salt represented by the following formula: The invention is a carbapenem compound which has a potent antibacterial activity over a broad range of Gram negative and Gr... | 04/17/2007 |
| RE39140 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/20/2006 |
| RE39131 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atoms or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted b... | 06/13/2006 |
| RE39127 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/13/2006 |
| RE39129 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/13/2006 |
| RE39130 | Heterocyclic compounds Novel heterocyclic compounds of the formula wherein, R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group which may be substituted by alkyl or a trimethylene group which may be substituted by... | 06/13/2006 |
| 6974830 | NR1H4 nuclear receptor binding compounds The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear re... | 12/13/2005 |
| 6960664 | Aza hydroxylated ethyl amine compounds Disclosed are compounds of formula: and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R... | 11/01/2005 |
| 6949536 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ... | 09/27/2005 |
| 6727238 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi... | 04/27/2004 |
| 6720427 | Thiazole derivatives The invention provides compounds of formula 1 wherein R1, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inh... | 04/13/2004 |
| 6706920 | Antistatic composition An antistatic composition comprises (a) at least one ionic salt consisting of a nonpolymeric nitrogen onium cation and a weakly coordinating fluoroorganic anion, the conjugate acid of the anion being a superacid; and (b) at least one thermoplastic polymer. The compo... | 03/16/2004 |
| 6706747 | Conformationally rigid bicyclic and adamantane derivatives useful as α2-adrenergic blocking agents A compound of formula I in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; ... | 03/16/2004 |
| 6699895 | 2-aminothiazoline derivatives and process for preparing the same The present invention relates to a class of 2-aminothiazoline derivatives of formula I: ##STR1## in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, --CH2 --R3, --C... | 03/02/2004 |
| 6677353 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 01/13/2004 |
| 6677341 | (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and m... | 01/13/2004 |
| 6670376 | Aryl aniline 댢 adrenergic receptor agonists The invention provides novel 댢 adrenergic receptor agonist compounds of formula (I): ##STR1## wherein R1 -R13 and w have any of the values described in the specification. The invention also provides pharmaceutic... | 12/30/2003 |
| 6586433 | Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 07/01/2003 |
| 6586456 | Aminothiazole derivatives and their use as CRF receptor ligands Substituted 4-phenyl-2-aminothiazole derivatives, processes for preparing the same, and the use thereof as corticotropin releasing factor (CRF) antagonists.... | 07/01/2003 |
| 6531497 | Epothilone derivatives and their synthesis and use The invention relates to epothilone analog represented by formula (I) wherein (i) R2 is absent or oxygen; "a" can be either a single or double bond; "b" can be either absent or a single bond; and "c" can be either absent or a single bond, with ... | 03/11/2003 |
| 6458803 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 10/01/2002 |
| 6448286 | Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.... | 09/10/2002 |
| 6348482 | Catechols as antimicrobial agents Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: ##STR1## wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino... | 02/19/2002 |
| 6319935 | Conformationally rigid bicyclic and adamantane derivatives useful as 댒-adrenergic blocking agents A compound of formula I ##STR1## in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or ... | 11/20/2001 |
| 6307090 | Acylated oligopeptide derivatives having cell signal inhibiting activity The invention relates to an acylated peptide, namely a compound of formula (I), ##STR1## wherein n is 0 to 15, X is oxalyl PTI is the bivalent radical of tyrosine or (preferably) the bivalent radical of phosphotyrosine or a phosphotyrosine mimetic, AA sta... | 10/23/2001 |
| 6300357 | Triazole antifungal agent A triazole compound having the formula: ##STR1## wherein Ar1 represents a phenyl group which may be substituted, Ar2 represents a heterocyclic group which may be substituted, R0 represents a hydrogen atom or a lower alkyl;... | 10/09/2001 |
| 6265553 | Intermediate thiazoles and process for the preparation of 2-chloro-5-chloromethyl-thiazole The present invention relates to intermediate thiazole compounds and a process for preparing 2-chloro-5-chloromethylthiazole which is a known compound useful for the preparation of insecticides.... | 07/24/2001 |
| 6187802 | Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use Compounds of Formula I ##STR1## including pharmaceutically acceptable salts thereof in the form of individual enantiomers, racemates, or other mixtures of enantiomers, in which Ar is phenyl, naphthyl or benzo[b]thiophenyl, each of which may be option... | 02/13/2001 |
| 6165943 | Thiazolimine derivatives Thiazolimine derivatives of the formula I ##STR1## where: X and Y independently of one another are each hydrogen, halogen, C1 -C4 -alkyl, C1 -C4 -haloalkyl; Z is hydrogen; Cl -C8 -alkyl, C | 12/26/2000 |
| 6107487 | Methine and azamethine dyes based on 5-membered heterocycles with a trifluoromethyl group Dyes of the formula Q-X=Het where X is nitrogen or CH, Q is a 5- or 6-membered carbocyclic or heterocyclic radical and Het is a radical of the formula ##STR1## where Y is oxygen, sulfur, imino, C1 -C4 -alkylimino, substituted o... | 08/22/2000 |
| 6096898 | One pot synthesis of 1,2,4-triazoles One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.... | 08/01/2000 |
| 6080772 | Thiazole compounds and methods of modulating signal transduction The present invention relates to thiazole containing compounds capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such compounds to modulate or regulate signal transduction by inhibiting protein tyrosi... | 06/27/2000 |
| 6057451 | Anti-herpesvirus compounds and methods for identifying, making and using same This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes h... | 05/02/2000 |
| 6057349 | 2-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides and ureas and their use The present invention concerns novel compounds represented by the Formula: ##STR1## wherein: A is R1q (R3 R60 N)m (Z)(NR2)n ; m and q are each 0 or 1, with the proviso that when ... | 05/02/2000 |