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| Number | Title | Issue Date |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7056939 | 4-(4Methoxybenzyl)-n′-(5-nitro1,3-thiazol-2-yl)urea and its use in the treatment of conditions associated with glycogen-synthase kinase-3 (gsk3) The present invention relates to a new compound of formula I as a free base or a pharmaceutically acceptable salt thereof, a process for the preparation, pharmaceutical formulations containing said therapeutically active compound and to the use of said compound in t... | 06/06/2006 |
| 6716850 | Non-nucleoside reverse transcriptase inhibitors Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)... | 04/06/2004 |
| 6552054 | Chromone derivatives, process for the preparation of the same and uses thereof The invention provides chromone derivatives of the following general formula, a process for preparing such chromone derivatives and a prophylactic and therapeutic agent comprising such chromone derivatives for bone diseases and chondropathy: ##STR1##... | 04/22/2003 |
| 6486184 | -acyl- and -heteroatom-substituted benzene acetamide glucokinase activators Substituted benzene acetamide compounds which are glucokinase activators and pharmaceutically acceptable salts thereof.... | 11/26/2002 |
| 6239152 | Oxazolidinone combinatorial libraries, compositions and methods of preparation Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as ph... | 05/29/2001 |
| 6211373 | Phenyl urea antagonists of the IL-8 receptor This invention relates to novel compounds of Formula (I), and a novel use of these compounds in treating chemokine mediated diseases, wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (1) are represented by the structure: #... | 04/03/2001 |
| 6190923 | Diethylenetriamine-N,N',N"-triacetic acid derivatives The present invention relates to the field of immunoassays for metal ions. The invention presents: chelators, chelates, antibodies specific for the chelates, tracers comprising chelates conjugated to detectable labels, and immunoassays utilizing the foreg... | 02/20/2001 |
| 6140330 | Thiazole derivative A thiazole compound of the formula: ##STR1## wherein T is lower alkylene; u is 0 or 1; R1 and R2 are the same or different and are each H, or lower alkyl, etc.; R3 is ##STR2## R4 is H or lower alkanoyl... | 10/31/2000 |
| 6117894 | Acid stabilized pharmaceutical compositions of tizoxanide and nitazoxanide The present invention relates to a pharmaceutical composition containing as active agent, solid particles of a compound selected from the group consisting of: compound of formula I: ##STR1## compound of formula II: ##STR2## and mixtures the... | 09/12/2000 |
| 6100282 | Thiazole derivatives Compounds of the formula: as well as pharmaceutically usable salts and esters thereof, wherein R1, R2 and R3 have the significance ascribed herein, inhibit binding of adhesive proteins to the surface of different types of ... | 08/08/2000 |
| 6096898 | One pot synthesis of 1,2,4-triazoles One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.... | 08/01/2000 |
| 5968961 | Pharmaceutical compositions of tizoxanide and nitazoxanide The present invention relates to a pharmaceutical composition containing as active agent, solid particles of a compound selected from the group consisting of: compound of formula I ##STR1## and mixtures thereof, said particles having a particle size ... | 10/19/1999 |
| 5935973 | Heterocyclcarboxamide derivatives and their use as therapeutic agents Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R1 is an optional substituent; U is an alkylene chain optionally substituted by one or more... | 08/10/1999 |
| 5925622 | Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same An aryl glucuronide of 2-hydroxy-N-(5-nitro-2-thiazolyl)benzamide, preferably an O-aryl glucuronide, as well as methods for the convenient synthesis of these aryl glucuronides, highly stable and low toxicity pharmaceutical composition containing these ary... | 07/20/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5917048 | Substituted aryl or heteroarylamides having retinoid-like biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.... | 06/29/1999 |
| 5808085 | Stereoselective preparation of 2-substituted succinic acid derivatives A highly efficient and practical means has been developed which enables compounds of the formula: ##STR1## wherein R1 is lower alkoxy, lower alkylamino, di-(loweralkyl) amino, or the monovalent radical A--NR3, wherein A is lower... | 09/15/1998 |
| 5747514 | Metalloproteinase inhibitors The present invention relates to therapeutically active hydroxamic acid and carboxylic acid derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to the use of such compounds in medicine. In particular, the c... | 05/05/1998 |
| 5700811 | Potent inducers of terminal differentiation and method of use thereof This invention is directed to compounds having the structure: ##STR1## wherein R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or uns... | 12/23/1997 |
| 5663185 | Heteroaromatic compounds and crop protection agents containing them Heteroaromatic compounds of the formulae IA and IB ##STR1## where the dashed line is a double bond between the carbon atom and a Z atom, and the index and the substituents have the following meanings: R1 alkyl, alkoxy, alkylamino R2 ... | 09/02/1997 |
| 5578621 | Benzamide derivatives The present invention relates to a new compound of formula I ##STR1## with one of the symbols R1, R2, R3, R4 and R5 representing OH, whereas the remaining symbols represent H; to a pharmaceutical... | 11/26/1996 |
| 5314891 | Benzenesulphonamide derivatives The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R2 and R3 together form --A2 --X2 --A3 -- which d... | 05/24/1994 |
| 5290802 | 3-substituted-2-oxindole derivatives This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H | 03/01/1994 |
| 5202340 | Amino acid derivatives The compounds of the formula: ##STR1## (wherein R1 is hydrogen or alkyl; R2 is carbocyclic or heterocyclic ring, unsubstituted or substituted by R3 s; R3 is halogen, trihalomethyl, hydroxy, alkyl, alkoxy, a... | 04/13/1993 |
| 5101035 | Merocyanine-like thiazole dyes and thermal transfer thereof Useful thermal transfer dyes are thiazole dyes having the formula ##STR1## where R1 and R2 are each, independently of the other, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted phenyl or cyclohexyl or ... | 03/31/1992 |
| 5087288 | Herbicidal thioparaconic acid derivatives A method of controlling plant growth is provided comprising applying to the plants or to a habitat thereof a herbicidally effective amount of a compound having the structure: ##STR1## wherein R1 is selected from the group consisting of car... | 02/11/1992 |
| 5084571 | Substituted thiazole dye compounds There are disclosed substituted thiazole dye compounds represented by the following Formula (I): Formula (I) ##STR1## wherein R1 represents a hydrogen atom or a group capable of substitution onto a benzene ring, n is an integer of 1 to 4, ... | 01/28/1992 |
| 5071865 | Pesticidal 2-acylamino-4-halogeno-5-nitrothiazoles Pesticidal 2-acylamino-4-halogeno-5-nitrothiazoles of the formula ##STR1## in which Hal represents halogen, x represents an integer 0 or 1, A represents O, S or N--R2, where R2 represents hydrogen, alkyl, alkenyl, halogenoalkyl, cyanoalky... | 12/10/1991 |
| 5043443 | Aminomethyloxooxazolidinyl arylbenzene derivatives Novel aminomethyloxooxazolidinyl arylbenzene derivatives, wherein the aryl includes the phenyl, substituted phenyl, pyridyl, and substituted pyridyl groups, such as (l)-N-{3-[4- (4'-pyridyl)phenyl]-2-oxooxazolidin-5-ylmethyl}acetamide, possess useful ... | 08/27/1991 |
| 5028708 | Azamethinyl quinoline derivatives This invention provides azamethine compounds represented by the formula (I): ##STR1## (wherein X represents ##STR2## Y represents C.dbd.O, C.dbd.C(CN)2 or SO2 ; R1 to R4 represent independently a ... | 07/02/1991 |
| 4996218 | Chloroaniline derivatives Compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof, which have 댢 -adrenoreceptor stimulant activity. They may be used in the treatment of diseases associated with reversible airwa... | 02/26/1991 |
| 4987146 | N-hetaryl imidazole derivatives N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R3 represents hydrogen, a straight or branched C1-6 -alkyl group, or ... | 01/22/1991 |
| 4942242 | Certain thiazol-4-yl-phenoxy derivatives having lipid lowering properties Thiazolyl phenoxy derivatives are provided as well as pharmaceutical compositions containing such derivatives. The compositions are useful for lowering lipid activity in a subject and accordingly useful for reducing cholesterol and triglycerides.... | 07/17/1990 |
| 4910313 | Diselenobis benzoic acid amides of primary heterocyclic amines, process for producing the same and process for the treatment of certain diseases in humans The present invention is related to new diselenobis benzoic acid amides of primary heterocyclic amines of the general formula I ##STR1## process for producing the same and process for treating certain diseases in human beings by administration of the... | 03/20/1990 |
| 4902700 | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients Disclosed are a thiazole derivative represented by the following formula, a pharmaceutically acceptable salt thereof and leukotriene antagonist containing the same as the active ingredients: ##STR1## wherein R1 and R2 each indep... | 02/20/1990 |
| 4863947 | N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of their production This invention relates to novel N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and processes for preparing these compounds.... | 09/05/1989 |
| 4692518 | Crystalline (7R)-7-amino-3-(1'-pyridiniummethyl)-3-cephem-4-carboxylate monohydrate compound Crystalline (7R)-7-amino-3-(1'-pyridiniummethyl)-3-cephem-4-carboxylate monohydrate compound is an intermediate in the synthesis of the cephalosporin antibiotic ceftazidime.... | 09/08/1987 |
| 4687857 | Alkyl ଲ-oxo-benzenepropanoates Novel alkyl ଲ-oxo-benzenepropanoates of the formula ##STR1## wherein X is in the 5-,6-,7- or 8-position and is selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF3 ... | 08/18/1987 |
| 4663341 | Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides This invention relates to N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and processes for preparing these compounds.... | 05/05/1987 |
