...that the Band-Aid Bandage was invented by a Johnson & Johnson employee whose wife had cut herself? Earl Dickson's wife was rather accident prone, so he set out to develop a bandage that she could apply without help. He placed a small piece of gauze in the center of a small piece of surgical tape, and what we know today as the Band Aid bandage was born!
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| Number | Title | Issue Date |
| 7982048 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m... | 07/19/2011 |
| 7388098 | Dynamic resolution of isomers and resolved isomers Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha substitution i... | 06/17/2008 |
| 7335778 | Intermediate for biotin and process for producing the same The present invention is to provide a process for preparing a synthetic intermediate of biotin which is industrially advantageous, and discloses a process for preparing a compound represented by the formula (I): | 02/26/2008 |
| 7323564 | Preparation of thiazoles The present invention is directed to a process for preparing a compound having the formula: wherein R is a range of organic groups and X is a leaving group. The process may include reacting a compound of the form... | 01/29/2008 |
| 7259157 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ... | 08/21/2007 |
| 7202404 | Fungicidal amides Compounds of Formula I are disclosed which are useful as fungicides wherein R1 is hydrogen; halogen; C1–C2 alkoxy; C1–C2 | 04/10/2007 |
| 7183301 | Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel oxazolidinone compounds of the general formula (I). where R1, R2, R3, Y1, Y2, Y3, and Z are as defined in t... | 02/27/2007 |
| 7129243 | Peptide compounds The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts... | 10/31/2006 |
| 7109223 | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EPreceptor agonists in the treatment of glaucoma This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a p... | 09/19/2006 |
| 6908939 | Biaromatic ligand activators of PPARγ receptors Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for regulatin... | 06/21/2005 |
| 6762198 | Dihetero-substituted metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): | 07/13/2004 |
| 6566381 | Hetero-substituted metalloprotease inhibitors Heterocyclic substituted compounds having the general structure: ##STR1## which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes.... | 05/20/2003 |
| 6528652 | Composition and device for detecting leukocytes in urine Thiazole esters are suitable for detecting the presence of leukocytes in urine. Such thiazole esters are suitable for use in compositions, diagnostic devices, and methods for detecting the presence of leukocytes. A thiazole ester of the invention is of th... | 03/04/2003 |
| 6452014 | Telomerase inhibitors and methods of their use Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be... | 09/17/2002 |
| 6432993 | Substituted fused heterocyclic compound Substituted fused heterocyclic compounds of the formula (I) and pharmacologically acceptable salts thereof: ##STR1## wherein R1 is a group of the formula (II) or (III): ##STR2## R4 is a substituted phenyl or a pyridyl which may have ... | 08/13/2002 |
| 6413997 | 3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds 3-(Substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of... | 07/02/2002 |
| 6369233 | Process for the preparation of thiazole derivatives The Invention relates to a process for the preparation of a compound of the formula ##STR1## wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting a c... | 04/09/2002 |
| 6252083 | Carbamates and crop protection agents containing them Carbamates of the formula I ##STR1## where the substituents have the following meanings: Z is methoxy, NH2, NHCH3, N(CH3)2, CH3, C2 H5, CF3 or CCl3, X and Y are ... | 06/26/2001 |
| 6177571 | Method for removing heavy metals from organic compounds A method for removing heavy metals, selected from palladium, tin and nickel, from heavy metal complexes with thiazole compounds in aqueous or alcoholic solution, by precipitation as sulfides, characterised in that such solutions are treated with a water-s... | 01/23/2001 |
| 6174908 | Potassium channel inhibitors Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases, conditions and disorders.... | 01/16/2001 |
| 6110946 | Antivirally active heterocyclic azahexane derivatives There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted or substituted by one or ... | 08/29/2000 |
| 6096898 | One pot synthesis of 1,2,4-triazoles One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.... | 08/01/2000 |
| 6075148 | Carbamates and crop protection agents containing them Carbamates of the formula I where the substituents have the following meanings: Z is methoxy, NH2, NHCH3, N(CH3)2, CH3, C2 H5, CF3 or CCl3, X and Y are identical... | 06/13/2000 |
| 6057349 | 2-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides and ureas and their use The present invention concerns novel compounds represented by the Formula: ##STR1## wherein: A is R1q (R3 R60 N)m (Z)(NR2)n ; m and q are each 0 or 1, with the proviso that when ... | 05/02/2000 |
| 6037354 | Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds ... | 03/14/2000 |
| 5990135 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 11/23/1999 |
| 5981532 | Carbamates and crop protection agents containing them Carbamates of the formula I ##STR1## wherein B is a saturated or unsaturated heterocyclic group, and the other substituents are defined in the specification, and having crop protection properties.... | 11/09/1999 |
| 5968958 | 5-Methanesulfonamido-3H-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2 The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of ... | 10/19/1999 |
| 5914328 | Heterocyclic ether compounds useful in controlling neurotransmitter release Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R1, R2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibi... | 06/22/1999 |
| 5824661 | Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S (b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing ... | 10/20/1998 |
| 5789404 | 3-substituted 1-arylindole compounds 3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or -thioxo; R1 -R4 are hydrog... | 08/04/1998 |
| 5750712 | 2-(n-cyanoimino)-thiazolidin-4-one derivatives A class of novenl compounds represented by the formula (I) ##STR1## wherein R1 s are the same or different groups and each represents hydrogen atom or alkyl group having 1 to 4 carbon atoms; R2 is phenyl group, naphthyl group, o... | 05/12/1998 |
| 5733936 | 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds, methods of preparing them and the use of these compounds in drugs are described.... | 03/31/1998 |
| 5728696 | Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides. The invention relates to compounds of the formula ##STR1## in which Ar... | 03/17/1998 |
| 5679795 | Method of synthesizing dyes and precursor compounds therefor A method of synthesizing a compound having a 1,3-thiazolidin-4-one ring appended at the 2-position by a double bond to the active methylene position of a ketomethylene or malononitrile moiety, which comprises reacting the corresponding ketomethylene compo... | 10/21/1997 |
| 5663185 | Heteroaromatic compounds and crop protection agents containing them Heteroaromatic compounds of the formulae IA and IB ##STR1## where the dashed line is a double bond between the carbon atom and a Z atom, and the index and the substituents have the following meanings: R1 alkyl, alkoxy, alkylamino R2 ... | 09/02/1997 |
| 5631376 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 05/20/1997 |
| 5622983 | N-substituted cycloalkyl and polycycloalkyl -substituted Trp-Phe- and phenethylamine derivatives Novel unnatural dipeptoids of -substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, colorectal tumors, or as antipsychotics are disclosed. Further the com... | 04/22/1997 |
| 5621109 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed wherein the terms R1, R2, R5, R6, Y, Y', m and n are herein defined.... | 04/15/1997 |
| 5618835 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.... | 04/08/1997 |