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Class 548/189 - Nitrogen attached indirectly to the thiazole ring by nonionic bonding


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein nitrogen is attached indirectly to the
No. of patents: 134
Last issue date: 07/19/2011


1        
NumberTitleIssue Date
7982048Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m...
07/19/2011
7388098Dynamic resolution of isomers and resolved isomers
Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha substitution i...
06/17/2008
7335778Intermediate for biotin and process for producing the same
The present invention is to provide a process for preparing a synthetic intermediate of biotin which is industrially advantageous, and discloses a process for preparing a compound represented by the formula (I):
02/26/2008
7323564Preparation of thiazoles
The present invention is directed to a process for preparing a compound having the formula: wherein R is a range of organic groups and X is a leaving group. The process may include reacting a compound of the form...
01/29/2008
7259157N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ...
08/21/2007
7202404Fungicidal amides
Compounds of Formula I are disclosed which are useful as fungicides wherein R1 is hydrogen; halogen; C1–C2 alkoxy; C1–C2
04/10/2007
7183301Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel oxazolidinone compounds of the general formula (I). where R1, R2, R3, Y1, Y2, Y3, and Z are as defined in t...
02/27/2007
7129243Peptide compounds
The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts...
10/31/2006
7109223Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EPreceptor agonists in the treatment of glaucoma
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a p...
09/19/2006
6908939Biaromatic ligand activators of PPARγ receptors
Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for regulatin...
06/21/2005
6762198Dihetero-substituted metalloprotease inhibitors
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I):
07/13/2004
6566381Hetero-substituted metalloprotease inhibitors
Heterocyclic substituted compounds having the general structure: ##STR1## which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes....
05/20/2003
6528652Composition and device for detecting leukocytes in urine
Thiazole esters are suitable for detecting the presence of leukocytes in urine. Such thiazole esters are suitable for use in compositions, diagnostic devices, and methods for detecting the presence of leukocytes. A thiazole ester of the invention is of th...
03/04/2003
6452014Telomerase inhibitors and methods of their use
Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be...
09/17/2002
6432993Substituted fused heterocyclic compound
Substituted fused heterocyclic compounds of the formula (I) and pharmacologically acceptable salts thereof: ##STR1## wherein R1 is a group of the formula (II) or (III): ##STR2## R4 is a substituted phenyl or a pyridyl which may have ...
08/13/2002
64139973-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds
3-(Substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of...
07/02/2002
6369233Process for the preparation of thiazole derivatives
The Invention relates to a process for the preparation of a compound of the formula ##STR1## wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting a c...
04/09/2002
6252083Carbamates and crop protection agents containing them
Carbamates of the formula I ##STR1## where the substituents have the following meanings: Z is methoxy, NH2, NHCH3, N(CH3)2, CH3, C2 H5, CF3 or CCl3, X and Y are ...
06/26/2001
6177571Method for removing heavy metals from organic compounds
A method for removing heavy metals, selected from palladium, tin and nickel, from heavy metal complexes with thiazole compounds in aqueous or alcoholic solution, by precipitation as sulfides, characterised in that such solutions are treated with a water-s...
01/23/2001
6174908Potassium channel inhibitors
Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases, conditions and disorders....
01/16/2001
6110946Antivirally active heterocyclic azahexane derivatives
There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted or substituted by one or ...
08/29/2000
6096898One pot synthesis of 1,2,4-triazoles
One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent....
08/01/2000
6075148Carbamates and crop protection agents containing them
Carbamates of the formula I where the substituents have the following meanings: Z is methoxy, NH2, NHCH3, N(CH3)2, CH3, C2 H5, CF3 or CCl3, X and Y are identical...
06/13/2000
60573492-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides and ureas and their use
The present invention concerns novel compounds represented by the Formula: ##STR1## wherein: A is R1q (R3 R60 N)m (Z)(NR2)n ; m and q are each 0 or 1, with the proviso that when ...
05/02/2000
6037354Alpha 1a adrenergic receptor antagonists
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds ...
03/14/2000
5990135Retroviral protease inhibiting compounds
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed....
11/23/1999
5981532Carbamates and crop protection agents containing them
Carbamates of the formula I ##STR1## wherein B is a saturated or unsaturated heterocyclic group, and the other substituents are defined in the specification, and having crop protection properties....
11/09/1999
59689585-Methanesulfonamido-3H-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of ...
10/19/1999
5914328Heterocyclic ether compounds useful in controlling neurotransmitter release
Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R1, R2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibi...
06/22/1999
5824661Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S (b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing ...
10/20/1998
57894043-substituted 1-arylindole compounds
3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or -thioxo; R1 -R4 are hydrog...
08/04/1998
57507122-(n-cyanoimino)-thiazolidin-4-one derivatives
A class of novenl compounds represented by the formula (I) ##STR1## wherein R1 s are the same or different groups and each represents hydrogen atom or alkyl group having 1 to 4 carbon atoms; R2 is phenyl group, naphthyl group, o...
05/12/1998
57339366-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients
6-dimethylaminomethyl-1-phenyl-cyclohexane compounds, methods of preparing them and the use of these compounds in drugs are described....
03/31/1998
5728696Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides
Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides. The invention relates to compounds of the formula ##STR1## in which Ar...
03/17/1998
5679795Method of synthesizing dyes and precursor compounds therefor
A method of synthesizing a compound having a 1,3-thiazolidin-4-one ring appended at the 2-position by a double bond to the active methylene position of a ketomethylene or malononitrile moiety, which comprises reacting the corresponding ketomethylene compo...
10/21/1997
5663185Heteroaromatic compounds and crop protection agents containing them
Heteroaromatic compounds of the formulae IA and IB ##STR1## where the dashed line is a double bond between the carbon atom and a Z atom, and the index and the substituents have the following meanings: R1 alkyl, alkoxy, alkylamino R2 ...
09/02/1997
5631376Retroviral protease inhibiting compounds
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed....
05/20/1997
5622983N-substituted cycloalkyl and polycycloalkyl ଱-substituted Trp-Phe- and phenethylamine derivatives
Novel unnatural dipeptoids of ଱-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, colorectal tumors, or as antipsychotics are disclosed. Further the com...
04/22/1997
5621109Retroviral protease inhibiting compounds
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed wherein the terms R1, R2, R5, R6, Y, Y', m and n are herein defined....
04/15/1997
5618835Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds....
04/08/1997
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