Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 7589213 | Therapeutic substituted lactams Therapeutic compounds, compositions, medicaments, and methods are disclosed herein. ... | 09/15/2009 |
| 7414137 | Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to novel compo... | 08/19/2008 |
| 7402600 | Nitroderivatives of cardiovascular agents Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C1 are two bi... | 07/22/2008 |
| 7220881 | Process for production of acid anhydride According to the present invention there is provided a process for producing an acid anhydride by reacting a carboxylic acid, preferably a carboxylic acid having a polymerizable group, with a sulfonyl halide compound in the presence of a tertiary amine or in the pre... | 05/22/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7105564 | Pharmaceutical composition comprising a dual antagonist against PGD/TXAreceptors having a [2.2.1] or [3.1.1] bicyclic skeleton The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D2 receptor and pharmaceutical compositions comprising them. A compound of the formula (I): | 09/12/2006 |
| 6987120 | Pharmaceutical compounds Compounds of their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C1 are two bi... | 01/17/2006 |
| 6942980 | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ... | 09/13/2005 |
| 6809107 | Neurotrophic pyrrolidines and piperidines, and related compositions and methods This invention provides compounds having the following general structures: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders... | 10/26/2004 |
| 6656911 | Serine protease inhibitors The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, s... | 12/02/2003 |
| 6656910 | Serine protease inhibitors The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, s... | 12/02/2003 |
| 6569874 | Thiazoles as factor Xa inhibitors The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is O or S and D may be C(.dbd.NH)NH2, which ar... | 05/27/2003 |
| 6559168 | Thiazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the for... | 05/06/2003 |
| 6403612 | Thrombin receptor antagonists A thrombin receptor antagonist having the formula ##STR1## or a pharmaceutically acceptable salt thereof, useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises ad... | 06/11/2002 |
| 6399783 | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents The invention relates to a method for preparing an ester, by admixing a compound having the structure I or IV: ##STR1## with a base and an alcohol to produce an ester, wherein the alcohol is a precursor to Taxol and its analogs. The present invention also... | 06/04/2002 |
| 6372913 | Process for preparing 2-substituted 5-formylthiazoles 2-substituted 5-formylthiazoles are prepared in an advantageous manner by reacting halogenomalonaldehydes in the presence of a solvent and a C1 -compound of the formula (III) ##STR1## in which X represents oxygen or sulfur and R1 is ... | 04/16/2002 |
| 6369225 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 04/09/2002 |
| 6355672 | Benzothiepin derivatives, process for the preparation of the same and uses thereof The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/12/2002 |
| 6331639 | Process for preparing 2-alkyl-3-aminothiophene derivative and 3-aminothiophene derivative A compound represented by the formula (1) which is useful as an agricultural fungicide or an intermediate thereof can be obtained by reacting a compound of the general formula (2) with a compound of the general formula (3) in the presence of an acid and r... | 12/18/2001 |
| 6255330 | Heterocyclically substituted phenylglycinolamides The heterocyclically substituted phenylglycinolamides are obtained by reaction of heterocyclically substituted phenylacetic acids with appropriate phenylglycinols. The heterocyclically substituted phenylglycinolamides are suitable as active compounds in m... | 07/03/2001 |
| 6184386 | Compound for photography A compound for photography is described, which is represented by following formula (I): ##STR1## wherein R1, R2, and R3 each represents a hydrogen atom or a group capable of being substituted; A and B each represents a hyd... | 02/06/2001 |
| 6124455 | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification have retinoid-like biological activity.... | 09/26/2000 |
| 6096898 | One pot synthesis of 1,2,4-triazoles One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.... | 08/01/2000 |
| 6080760 | Alpha 1A adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds ... | 06/27/2000 |
| 6037354 | Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds ... | 03/14/2000 |
| 6022868 | Substituted azacyclic or azabicyclic compounds Disclosed are compounds of formula (I) selected from the following ##STR1## wherein Y is ##STR2## and wherein A, B, C, D, R, k, m, n, o, p, s, t and u are as defined in the specification. These compounds are useful in treating diseases in the ... | 02/08/2000 |
| 6004543 | L-2-oxothiazolidine-4-carboxylic acid derivatives and use thereof for skincare The invention relates to novel compounds of formula (I): ##STR1## where R1 is chosen from hydrogen, saturated or unsaturated linear or branched C1 to C8 alkyl groups which are optionally substituted with a substituent, and optionally substituted benz... | 12/21/1999 |
| 5973161 | Enantioselective synthesis of cyclopentenes Methods of synthesizing compounds of the Formula V: ##STR1## wherein Xc is a chiral auxiliary, m is from 1 to 4, and R8 is hydrogen or --OH, are provided. Additionally, methods of synthesizing compounds of the Formula XII: ##STR... | 10/26/1999 |
| 5935973 | Heterocyclcarboxamide derivatives and their use as therapeutic agents Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R1 is an optional substituent; U is an alkylene chain optionally substituted by one or more... | 08/10/1999 |
| 5925658 | Optically active thiazolidinone derivative An optically active thiazolidinone derivative having the general formula: ##STR1## wherein: R1 represents a hydrogen atom, a C1 -C4 alkyl group, a phenyl group, a substituted phenyl group (said substituent represents ... | 07/20/1999 |
| 5869679 | Methods for preparing l-2-oxothiazolidine-4-carboxylate and its carboxylic acid Method for synthesizing L-2-oxothiazolidine-4-carboxylate and its acid, L-2-oxothiazolidine-4-carboxylic acid. The present invention involves the separation of phenol from a reaction mixture containing L-2-oxothiazolidine-4-carboxylate and phenol. In the ... | 02/09/1999 |
| 5861380 | Serine protease inhibitors-keto and di-keto containing ring systems The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respira... | 01/19/1999 |
| 5846988 | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents Compounds useful as cytoprotective agents are disclosed. The compounds possess dual activity, containing a phenolic portion selected to have antioxidant or free radical scavenging properties and a thiazolidine-4-carboxylate portion selected for its potent... | 12/08/1998 |
| 5843973 | Thiazolidinone compounds and composition for angina pectoris comprising the compounds as an active ingredient A thiazolidinone compound represented by general formula (I) or a pharmacoligically acceptable salt thereof, ##STR1## wherein W represents sulfur or oxygen and X represents --N(R1)--, or alternatively X represents sulfur or oxygen and W re... | 12/01/1998 |
| 5795890 | Sulfonamide derivatives A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.... | 08/18/1998 |
| 5773491 | (Co)polycarbonates stabilized against γ-radiation The object of the present invention is polycarbonate molding compositions containing polycarbonates, stabilizers of the general formula (I) R1 --X--CZ--Y--R2 and optionally polypropylene glycols. The object of the present invention is als... | 06/30/1998 |
| 5693594 | Herbicidal thiazole derivatives A compound of general formula (I) wherein: A represents a group of general formula (1) or (2) in which each X independently represents a halogen atom or an optionally substituted alkyl, cycloalkyl, alkoxy, aryl or aryloxy group, or an alkenyloxy, alkynylo... | 12/02/1997 |
| 5693310 | Amide complexes Compounds of general Formula I ##STR1## wherein R3 is a saturated, unsaturated, straight- or branched-chain or cyclic aliphatic hydrocarbon residue of up to 16 carbon atoms or, if R4 is a hydrogen atom, a cycloalkyl group or an ... | 12/02/1997 |
| 5672710 | Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity | 09/30/1997 |
| 5618835 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.... | 04/08/1997 |
