Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7884210 | Ureido-thiazole glucokinase activators The invention provides a compound of general formula (I) wherein the compounds are of the class ureido-thiazole glucokinase activators, useful for the treatment of various diseases, for example, type 2 diabetes. ... | 02/08/2011 |
| 7880012 | Benzamide glucokinase activators The present invention relates to N-heteroaryl-benzamides of the formula (I), pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful as glucokinase activators. ... | 02/01/2011 |
| 7851636 | Heteroaryl-ureas and their use as glucokinase activators This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity i... | 12/14/2010 |
| 7582769 | Dicycloalkyl urea glucokinase activators Dicycloalkyl urea glucokinase activators compounds are glucokinase inhibitors useful for the treatment of diabetes. (I) ... | 09/01/2009 |
| 7544808 | Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula ... | 06/09/2009 |
| 7312350 | Process for preparing arylalkynes The invention relates to a process for preparing arylvinyl halides and sulphonates and arylalkynes by reacting haloaromatics or aryl sulphonates with vinyl halides or sulphonates in the presence of a palladium catalyst and a base and, if appropriate, subsequent elim... | 12/25/2007 |
| 7183302 | Iminothiazolidinones as inhibitors of HCV replication Compounds having the structure of formula I are described wherein R, R′, R1, R2, and R3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV) repl... | 02/27/2007 |
| 7161006 | Sulphones for inhibition of gamma secretase The invention provides compounds of formula I: which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease. ... | 01/09/2007 |
| 7105553 | Thiazolyl amide derivatives The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments. ... | 09/12/2006 |
| 7045535 | Compounds useful for inhibiting paramyxovirus neuraminidase Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas: ... | 05/16/2006 |
| 6790978 | Thyromimetic organic compounds Compounds of the present invention of the formula are thyromimetic agents which can be used to prevent and/or treat diseases associated with an imbalance of thyroid hormones, such as hypo- and hyper-thyroidism, obesity, ... | 09/14/2004 |
| 6743790 | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use The present invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5, R6, A, X, m and n have the meanings indicated in the claims. The... | 06/01/2004 |
| 6613911 | Process for preparing arylacetylaminothiazoles The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-arylacetylaminothiazole compounds of formula I: ##STR1## or a pharmnaceutically acceptable salt thereof, wherein: R1, R2, ... | 09/02/2003 |
| 6610687 | Benzofuranylsulfonates ##STR1## The invention relates to benzofuranylsulfonates of the general formula (I), their preparation and their use for the treatment of inflammation.... | 08/26/2003 |
| 6515004 | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases The present invention describes compounds of formula I: ##STR1## and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula I compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases,... | 02/04/2003 |
| 6500817 | Thiazolyl urea derivatives and their utilization as antiviral agents The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.... | 12/31/2002 |
| 6498172 | Prostaglandin agonists and their use to treat bone disorders This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 12/24/2002 |
| 6476055 | 5,5-disubstituted thiazolidine derivative pesticides Fungicidal 5, 5-disubstituted thiazolidine derivatives are provided having the formula: ##STR1## wherein R1 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cycloalkyl, or optionally substituted phenyl; R2 is C2-C6 alkyl or optionally substituted phenyl; X is ... | 11/05/2002 |
| 6413997 | 3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds 3-(Substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of... | 07/02/2002 |
| 6414156 | Process for preparing azacycloalkanoylaminothiazoles The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-azacycloalkanoylaminothiazole compounds of formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R is alkyl, aryl or heteroaryl... | 07/02/2002 |
| 6395282 | Immunogenic conjugates of Gram-negative bacterial autoinducer molecules The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine fo... | 05/28/2002 |
| 6392053 | Process for preparing arylacetylaminothiazoles The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-arylacetylaminothiazole compounds of formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R1, R2, R... | 05/21/2002 |
| 6214852 | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases The present invention describes compounds of formula I ##STR1## and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula I compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases, ... | 04/10/2001 |
| 6124333 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124332 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6110946 | Antivirally active heterocyclic azahexane derivatives There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted or substituted by one or ... | 08/29/2000 |
| 6096898 | One pot synthesis of 1,2,4-triazoles One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.... | 08/01/2000 |
| 6040321 | Aminothiazole inhibitors of cyclin dependent kinases Compounds of the formula ##STR1## and pharmaceuticaly acceptable salts thereof. As used in formula I, and throughout the specification, the symbols have the following meanings: R1 and R2 are independently hydrogen, fluorine or alkyl;... | 03/21/2000 |
| 5935973 | Heterocyclcarboxamide derivatives and their use as therapeutic agents Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R1 is an optional substituent; U is an alkylene chain optionally substituted by one or more... | 08/10/1999 |
| 5919809 | 3-substituted-2-oxindole derivatives This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the pharmaceutically-acceptable salts thereof which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynt... | 07/06/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5714499 | 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease ... | 02/03/1998 |
| 5663185 | Heteroaromatic compounds and crop protection agents containing them Heteroaromatic compounds of the formulae IA and IB ##STR1## where the dashed line is a double bond between the carbon atom and a Z atom, and the index and the substituents have the following meanings: R1 alkyl, alkoxy, alkylamino R2 ... | 09/02/1997 |
| 5594016 | Naphthalene derivatives Naphthalene derivatives represented by the formula (I): ##STR1## wherein the symbol ##STR2## --X-- represents --O-- or --S--, .dbd.Y-- represents .dbd.N-- or .dbd.CR5 --, R1, C2, R3, R4 and ... | 01/14/1997 |
| 5538991 | Endothelin antagonists bearing 5-membered heterocyclic amides Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral... | 07/23/1996 |
| 5413997 | Triphenylmethane derivatives A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.... | 05/09/1995 |
| 5369107 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same Compounds of the formula: ##STR1## wherein A is S, SO, or SO2, R1 is H or acyl, R2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R3 is pyridyl are claimed. The compounds are useful as therapeutic agent... | 11/29/1994 |
| 5362880 | Method of preparing a magenta development inhibitor releasing coupler Disclosed is a method of preparing a photographic coupler comprised of 1-aryl-3-substituted-4-heterocyclic-5-pyrazolone development inhibitor releasing coupler for use in a photographic element, said coupler capable of reacting with oxidized color develop... | 11/08/1994 |
| 5344927 | Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same A tetrahydrobenzimidazole derivative represented by formula (I): ##STR1## wherein Het represents a heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, ... | 09/06/1994 |
| 5342937 | Heterocyclic thione A solvent soluble heterocyclic o-hydroxy thione carrying a lipophilic group and the process for the selective extraction of gallium, and certain other related metals, especially from solutions containing excess aluminium.... | 08/30/1994 |
