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| Number | Title | Issue Date |
| 7795442 | Preparation of thiazoles A process is provided for preparing compounds having the general formula I wherein R is a range of organic groups and X is a leaving group. The process comprises reacting a compound of formula II | 09/14/2010 |
| 7781594 | 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the treatment of acute and chronic inflammatory diseases The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, and to a method for the treatment an acute or chronic inflammatory disease by inhibiting the product... | 08/24/2010 |
| 7598391 | Heteroaryl-ureas and their use as glucokinase activators This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity i... | 10/06/2009 |
| 7439260 | 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents. | 10/21/2008 |
| 7378530 | Anti-cancer and anti-microbial 5-membered heterocyclic compounds Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activit... | 05/27/2008 |
| 7358266 | Cyclopropyl and cyclobutyl epothilone analogs The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and ... | 04/15/2008 |
| 7342039 | Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them. ... | 03/11/2008 |
| 7323564 | Preparation of thiazoles The present invention is directed to a process for preparing a compound having the formula: wherein R is a range of organic groups and X is a leaving group. The process may include reacting a compound of the form... | 01/29/2008 |
| 7320974 | Cytoskeletal active compounds, compositions and use The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable... | 01/22/2008 |
| 7273885 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents.... | 09/25/2007 |
| 7264813 | Therapeutic uses of powder A method for treating a disease selected from diabetes mellitus and atherosclerosis, and a method for reducing triglycerides and/or increasing HDL cholesterol levels in the plasma of a subject. The method comprises administrating. to a subject an effective amount of... | 09/04/2007 |
| 7256211 | 8-azaprostaglandin derivatives and medical use thereof The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification)... | 08/14/2007 |
| 7253196 | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R | 08/07/2007 |
| 7183301 | Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel oxazolidinone compounds of the general formula (I). where R1, R2, R3, Y1, Y2, Y3, and Z are as defined in t... | 02/27/2007 |
| 7169930 | Analogs of epothilone Designed epoxide and cyclopropane epothilone analogs with substituted side-chains are disclosed and characterized with respect to their biological activities against a series of human cancer cell lines. Among the several bioactive analogs, the epothilone B analog wi... | 01/30/2007 |
| 7148219 | Biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety th... | 12/12/2006 |
| 7144905 | Small molecules used to increase cell death The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death. ... | 12/05/2006 |
| 7119111 | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and m... | 10/10/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7078527 | Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles The present invention relates to a process for preparing compounds of the formula (I) where R is H or F, by (a) reacting a compound of the formula (II) | 07/18/2006 |
| 7052742 | Five membered-ring compounds and utilization thereof in liquid crystal mixtures Fluorinated five-membered ring compounds of the formula (I) R1—X—(A1—M1)a—(A2—M2)b—A3—Y—E (I) where E is a radical T—Z—R2 | 05/30/2006 |
| 6987104 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in th... | 01/17/2006 |
| 6963000 | Benzothiazole derivatives with activity as adenosine receptor ligands The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor. ... | 11/08/2005 |
| 6900218 | Pyruvate derivatives Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes... | 05/31/2005 |
| 6878727 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus ... | 04/12/2005 |
| 6821994 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a compound of formula (I) (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having a... | 11/23/2004 |
| 6762198 | Dihetero-substituted metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): | 07/13/2004 |
| 6734198 | Nematicidal trifluorobutenes The invention relates to compounds of formula (I) in which X represents halogen, and n represents 0, 1 or 2, to a process for their preparations and to their use as nematacides. ... | 05/11/2004 |
| 6727268 | 2-thioxothiazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 2-thioxothiazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein: | 04/27/2004 |
| 6710045 | Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (IV) The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which m represents integers from 3 to 10, n represents 0, 1 or 2 and Het represents the following, i... | 03/23/2004 |
| 6680387 | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analog... | 01/20/2004 |
| 6677457 | Process for the preparation of thiazole derivatives The invention relates to a process for the preparation of a compound of the formula ##STR1## wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting... | 01/13/2004 |
| 6667318 | LFA-1 antagonist compounds The invention relates to novel compounds having formula (I) ##STR1## wherein Cy, X, Y, L and R1-6 are as defined herein. The compounds bind CD11/CD18 adhesion receptors such as Lymphocyte Function-associated Antigen-1 (LFA-1) and are therefore ... | 12/23/2003 |
| 6656939 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula III: ##STR1## wherein Z1, Z2, and Z3 are as described in the specification; Q is --S--, --O--, --N(R4)--, or --CH(R6)--; R1 is T... | 12/02/2003 |
| 6620813 | Hydroxamate derivatives of non-steroidal anti-inflammatory drugs In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and 5-lipoxygenase (5-LO); as anticancer agents (through promoting ... | 09/16/2003 |
| 6617339 | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described.... | 09/09/2003 |
| 6589969 | Carboxylic acid derivatives and drugs containing the same as the active ingredient A peroxisome proliferator activated receptor regulator containing a compound of formula (I) ##STR1## (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compo... | 07/08/2003 |
| 6566381 | Hetero-substituted metalloprotease inhibitors Heterocyclic substituted compounds having the general structure: ##STR1## which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes.... | 05/20/2003 |
| 6544931 | Substituted heteroaryloxyacetanilides and their use as herbicides The invention relates to novel substituted heteroaryloxyacetanilides of the general formula (I), ##STR1## in which n, R, X, and Z are to intermediates for their preparation and to their use as herbicides.... | 04/08/2003 |
| 6541016 | Mixtures of alkylphosphoric esters and use thereof as cosmetic and pharmaceutical emulsifiers This invention relates to monoalkyl phosphoric esters, dialkyl phosphoric esters, and, in small amounts, trialkyl phosphoric esters or salts thereof, which are preferably based on ଲ-branched fatty alcohols, particularly Guerbet alcohol, which are ef... | 04/01/2003 |
