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| Number | Title | Issue Date |
| 8178687 | Derivatives of pyrroloindole which are inhibitors of Hsp90, compositions containing same, and use thereof Pyrroloindoles of formula (I) are provided wherein Het is an aromatic or partially unsaturated, monocyclic or bicyclic heterocycle containing between 1 and 4 heteroatoms N, O or S, optionally substituted by R1 or R′1 which are the same or different; R is X-(A-B)n-... | 05/15/2012 |
| 8143415 | Processes for making epothilone compounds and analogs A process for making epi-epothilone compounds according to formula A.1, by reacting a compound according formula C with at least one halogenating agent followed by treatment with ... | 03/27/2012 |
| 8044213 | Thiazolyl-benzimidazoles The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof. ... | 10/25/2011 |
| 7622592 | Carbonylamino-benzimidazole derivatives as androgen receptor modulators Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the ute... | 11/24/2009 |
| 7560568 | Thiazole compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.... | 07/14/2009 |
| 7504513 | Thiazolyl-benzimidazoles The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof. ... | 03/17/2009 |
| 7470793 | Thiazol-(bi)cycloalkyl-carboxanilides This invention relates to novel thiazole(bi)cycloalkylcarboxanilides of the formula (I) in which Q and R1 are as defined in the disclosure, to a process for preparing these compounds and ... | 12/30/2008 |
| 7470792 | Process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same The present invention provides a synthesis for the preparation of epothilone derivatives of formula 9 wherein R1 is methyl, and R2 is an unsubstituted or substituted aryl; an unsubstituted or substituted heteroaryl; or an u... | 12/30/2008 |
| 7439258 | Viral polymerase inhibitors A compound of the formula I: wherein: X is CH or N; Y is O or S; Z is OH, NH2, NMeR3, NHR3; OR3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S... | 10/21/2008 |
| 7423058 | Inhibitors of hepatitis C virus NS3 protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 09/09/2008 |
| 7399765 | Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute... | 07/15/2008 |
| 7396833 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of ... | 07/08/2008 |
| 7396838 | Use of 1H-indol-3-yl-2-oxoacetamide compounds A method of treating cancer including administering to a subject in need thereof an effective amount of a compound of the formula 1: wherein R1, R2, R3, R4, and n are as defined h... | 07/08/2008 |
| 7348425 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 03/25/2008 |
| 7342030 | Indole derivatives The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions contai... | 03/11/2008 |
| 7342041 | 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 03/11/2008 |
| 7262200 | Indazolinone compositions useful as kinase inhibitors The present invention provides compounds of formula I: These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK... | 08/28/2007 |
| 7241899 | Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 07/10/2007 |
| 7241555 | Optical information recording medium and method for recording information The present invention provides an optical information recording medium including a substrate; and a recording layer provided onto the substrate, to which information can be recorded and from which the information can be replayed by irradiating the medium with a lase... | 07/10/2007 |
| 7235572 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents This invention relates to compounds of the formula wherein one of R6, R7 or R8 is and all enantiomers and pharmaceutically a... | 06/26/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7205406 | Azomethine dye and metal complex dye, as well as color toner and ink-jet ink using the same An azomethine dye represented by the following Formula 1: wherein Y represents a substituent of 0.2≦σp≦0.9, Z1 and Z2 each represent —CR1═, where R1 represents... | 04/17/2007 |
| 7205330 | Inhibitors of hepatitis C virus NS3 protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 04/17/2007 |
| 7166715 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and... | 01/23/2007 |
| 7166615 | Substituted indolinones, preparation thereof and their use as pharmaceutical compositions Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases. ... | 01/23/2007 |
| 7157585 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 01/02/2007 |
| 7153848 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 12/26/2006 |
| 7144903 | CCR4 antagonists Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds ... | 12/05/2006 |
| 7141672 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. ... | 11/28/2006 |
| 7122674 | Process for preparing high-purity hydroxyindolylglyoxylamides The invention relates to a process for preparing hydroxyindolylglyoxylamides in high yields and particularly pure form. ... | 10/17/2006 |
| RE39356 | Process for the preparation of epothilone analogs The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction ... | 10/17/2006 |
| 7119104 | Activator of peroxisome proliferator-activated receptor delta A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B | 10/10/2006 |
| 7119209 | Process for preparing indolinone derivatives The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process. ... | 10/10/2006 |
| 7119086 | Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopress... | 10/10/2006 |
| 7115596 | Thiazole compounds as integrin receptor antagonists derivatives The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of ... | 10/03/2006 |
| 7115644 | Heterocyclic compounds Disclosed are benzimidazolone compounds of formulas (I) & (II): wherein R1, R2, R3, R4, R5, X, L, m, n and t are defined herein. The compounds inhibit production of cytokines involved in inflammatory proc... | 10/03/2006 |
| 7112600 | Fused-ring compounds and use thereof as drugs The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a therape... | 09/26/2006 |
| 7094794 | Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to t... | 08/22/2006 |
| 7087576 | Dipeptide phenyl ethers Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune disease... | 08/08/2006 |
| 7078149 | Optical recording medium and method for making the same A method for fabricating an optical recording medium is provided. A dye layer is formed on a molded substrate by spin-coating. A reflection layer is formed on the dye layer by sputtering so that the optical disc has enough reflection rate. The dye layer comprises a ... | 07/18/2006 |
