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| Number | Title | Issue Date |
| 7893272 | Reagents and kits for detection of influenza virus and the like The present invention relates to reagents and methods for influenza virus detection. These reagents and methods disclosed in the present invention enable simple, rapid, specific and sensitive detection of influenza virus types A and B. These reagents are N-acetylneu... | 02/22/2011 |
| 7692022 | Luminescence-based methods and probes for measuring cytochrome P450 activity The present invention provides methods, compositions, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step... | 04/06/2010 |
| 7495106 | -aminophenol-containing AB-monomer for heterocyclic rigid-rod polymers A novel o-aminophenol-carboxylic AB-monomer with the following chemical structure: for synthesizing new rigid-rod polybenzobisazoles was prepared from the corresponding nitrobenzothiazolecarboxylic acid via an enzymatic pro... | 02/24/2009 |
| 7335674 | Benzothiazole-4,7-diones and benzoxazole-4,7-diones with substituents in position 5 or 6 and method for production thereof A targetted production method for benzothiazole-4,7-dione and benzoxazole-4,7-dione derivatives, mono-substituted in the 5 or 6 position with an amino group, itself optionally substituted. ... | 02/26/2008 |
| 7332354 | Compounds for chemiluminescense procedures The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converte... | 02/19/2008 |
| 7309715 | Compound A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl... | 12/18/2007 |
| 7208450 | Pesticidal (dihalopropenyl) phenylalkyl substituted benzoxazole and benzothiazole derivatives Certain novel (dihalopropenyl)phenylalkyl substituted benzoxazole and benzothiazole derivatives have unexpected insecticidal activity. These compounds are represented by formula (I): where R through R11, inclusively. x, A, B, y, D, E and G are fully descr... | 04/24/2007 |
| 7144893 | 4-aryl quinols and analogs thereof as therapeutic agents The present invention pertains to compounds of the formula (1) which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitor: wherein: Q is ═O or ═N—S(... | 12/05/2006 |
| 7129258 | Substituted benzoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X a... | 10/31/2006 |
| 7125863 | Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t... | 10/24/2006 |
| 7045518 | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, rela... | 05/16/2006 |
| 7041691 | Compounds for the modulation of PPARγ activity Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 05/09/2006 |
| 6949543 | Amide derivative The invention relates to a novel amide derivative which is an N-({[4-(substituted thiazol-4-yl)phenyl]carbamoyl}methyl)amide derivative having a characteristic in that an aryl or heteroaryl group as an aromatic ring group is directly substituted on the N atom of ami... | 09/27/2005 |
| 6852548 | Benzothiazole dioxetanes Chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature, represented by the formulas I or II: wherein T is: | 02/08/2005 |
| 6852711 | HIV protease inhibitors The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the... | 02/08/2005 |
| 6723741 | Benzimidazoles and benzothiazoles and uses thereof This invention is directed to novel indole and benzothiazole compounds which are selective for cloned human alpha 2 receptors. This invention is also related to uses of these compounds for any indication where use of an alpha 2 agonist may be appropriate. Specifical... | 04/20/2004 |
| 6716865 | Benzoxa- and benzthiazoles Benzoxa- and benzthiazoles substituted at the 2 position and carrying a sulfamic acid ester group bound via oxygen to the phenyl part of the ring structure, such as the compounds of formula (I) wherein the symbols have various significances, possess interesting phar... | 04/06/2004 |
| 6667307 | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu... | 12/23/2003 |
| 6498177 | Indole and benzothiazole derivatives This invention is directed to novel indole and benzothiazole compounds which are selective for cloned human alpha 2 receptors. This invention is also related to uses of these compounds for any indication where use of an alpha 2 agonist may be appropriate.... | 12/24/2002 |
| 6495693 | N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 12/17/2002 |
| 6482859 | Microbicidal N-sulfonylglycin alkynyloxyphenethyl amide derivatives The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsu... | 11/19/2002 |
| 6469004 | Benzoheterocycles and their uses as MEK inhibitors The invention provides compounds having formula (I), wherein W is OH, or derivatives of the carboxylic acid, and Q is a heterocyclo-condensed ortho-phenylene residue. These compounds are useful as MEK inhibitors, particularly in the treatment of prolifera... | 10/22/2002 |
| 6436978 | Guanidinylamino heterocycle compounds useful as -2 adrenoceptor agonists This invention involves compounds having the following structure: ##STR1## as described in the Claims; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmac... | 08/20/2002 |
| 6380188 | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu... | 04/30/2002 |
| 6362205 | Substituted 3,3-diamino-2-propenenitriles, their preparation and use Described are substituted cyanoenamines of formula I ##STR1## wherein Z, R1, R2 and R3 are defined in the description, compositions thereof and methods for preparing these compounds. These compounds are useful in the treat... | 03/26/2002 |
| 6358885 | Substituted phenylheterocyclic herbicides This invention relates to certain phenylheterocyclic compounds, herbicidal compositions thereof and a method for their use as general and selective preemergent or postemergent herbicides or plant growth regulants.... | 03/19/2002 |
| 6310080 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, rela... | 10/30/2001 |
| 6307090 | Acylated oligopeptide derivatives having cell signal inhibiting activity The invention relates to an acylated peptide, namely a compound of formula (I), ##STR1## wherein n is 0 to 15, X is oxalyl PTI is the bivalent radical of tyrosine or (preferably) the bivalent radical of phosphotyrosine or a phosphotyrosine mimetic, AA sta... | 10/23/2001 |
| 6303643 | Substituted indoles and uses thereof This invention is directed to indole and benzothiazole compounds which are selective for cloned human alpha 2 receptors. This invention is also related to uses of these compounds for any indication where use of an alpha 2 agonist may be appropriate. Speci... | 10/16/2001 |
| 6277849 | N-sulphonyl and N-sulphinyl amino acid amides as microbiocides The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsubs... | 08/21/2001 |
| 6232498 | Process for the preparation of benzothiazolone compounds There are described processes for the preparation of a compound of formula I ##STR1## and novel intermediates in the preparative process.... | 05/15/2001 |
| 6214861 | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected heterocycle carbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, mo... | 04/10/2001 |
| 6169085 | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu... | 01/02/2001 |
| 6156891 | Production of pyridazine herbicides Carboxylic acids of formula (1): ##STR1## wherein R2 and R3 are independently hydrogen or C1 -C3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one d... | 12/05/2000 |
| 6153642 | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents Benzoheterocyclic distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; A is O, S, or NR, wherein R is hydrogen or C1 -C4 alkyl; B is CH or N; R1 is hydrogen or C1 -C4 alkyl; T is selected fr... | 11/28/2000 |
| 6147219 | Process for the preparation of benzothiazolone compounds There are described processes for the preparation of a compound of formula I ##STR1## and novel intermediates in the preparative process.... | 11/14/2000 |
| 6143747 | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: ##STR1## or a... | 11/07/2000 |
| 6136831 | Pyrazole derivatives and COX inhibitors containing them The purpose is to provide anti-inflammatory agents which have potent pharmacological actions and exert a selective inhibitory activity on COX-2, thereby being expected to reduce adverse effects such as disorders in gastric mucosa. The present invention en... | 10/24/2000 |
| 6034246 | 2-arylbenzazole compounds There are disclosed herein 2-phenylbenzazole compounds having a 3'-substituent and a 4'-NR2 R6 substituent in the phenyl group where R5 and R6 are each hydrogen or alkyl, or where the $'-NR5 R6 | 03/07/2000 |
| 5985870 | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu... | 11/16/1999 |
