Class 548/171 - Nitrogen bonded directly to the -C(=X)- group

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which nitrogen is bonded directly to the group.
No. of patents: 102
Last issue date: 10/24/2006

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Number	Title	Issue Date
7125863	Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t...	10/24/2006
6825223	Anilide compounds and pharmaceutical compositions comprising them The invention provides novel anilide compounds and pharmaceutical compositions comprising them. The invention relates to compounds of a formula: wherein Ar is an optionally-substituted aryl group; ...	11/30/2004
6713477	Hydroxamic acid derivatives A hydroxamic acid derivative represented by formula (1) or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which has a matrix metalo-proteinase inhibitor. ...	03/30/2004
6603044	Phthalamide derivatives, or salt thereof agrohorticultural insecticide, and method for using the same The present invention provides a phthalamide derivative of the formula (I): ##STR1## wherein A1 is (substituted) C1 -C8 alkylene, (substituted) C3 -C8 alkenylene, (substituted) C3 -C8...	08/05/2003
6596738	Heterocyclic compound, composition and method for inhibiting adenosine deaminase Heterocyclic compounds of the following formula: ##STR1## wherein B is ##STR2## [wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; and X is hydrogen or hydroxy protective group], lower alkanoyl or hydroxyimino(lo...	07/22/2003
6569855	Substituted cyclic amine metalloprotease inhibitors The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a stru...	05/27/2003
6518292	Heterocyclic aromatic compounds usefuls as growth hormone secretagogues Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocycl...	02/11/2003
6472414	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters...	10/29/2002
6417219	Hetero-substituted cyclic amine metalloprotease inhibitors The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a stru...	07/09/2002
6362208	Anilide compounds and drugs containing the same The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same. The invention relates to a compound represented by the following general formula: ##STR1## represents a divalent residue of benzene with a substituent(...	03/26/2002
6362138	Heterocyclic thioethers as additives for lubricants This invention relates to compounds which are suitable as ash-free antiwear additives and antioxidants, to lubricant compositions comprising said compounds as well as to their use. ##STR1## are particularly preferred. In the preferred compounds I', R...	03/26/2002
6204278	Anilide compounds, including use thereof in ACAT inhibitition The invention provides novel anilide compounds and pharmaceutical compositions comprising them. The invention relates to compounds of a formula: ##STR1## where Ar is an optionally-substituted aryl group; R4 and R5 are the same or differen...	03/20/2001
6177572	Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed....	01/23/2001
6172057	N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase...	01/09/2001
6150307	Heterocyclic thioethers as additives for lubricants This invention relates to compounds which are suitable as ash-free antiwear additives and antioxidants, to lubricant compositions comprising said compounds as well as to their use. Compounds of formulae ##STR1## are particularly preferred. In the pre...	11/21/2000
6028069	Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter Cyclic sulphones of formula (I) are disclosed, in which: R1 and R2 each independently of one another stand for H, A, CF3, CH2 F, CHF2, C2 F5, Hal, OH, OA, NH2, NHA, NA...	02/22/2000
5981559	Azole derivative with leukotriene (LTs) antagonizing activity and thromboxane (TX) A₂ antagonizing activity An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and being useful in preventing or treating allergic diseases, i...	11/09/1999
5942535	a!-Annelated pyrrole derivatives and pharmaceutical use thereof The present invention relates to heterocyclic compounds of the formula ##STR1## in which R1 -R7, B, a and X have the meanings recited in the specification. These compounds are usable in the treatment of diseases of the rheumatoi...	08/24/1999
5929100	Biologically active benzothiazolone ethanamines Compounds of formula I, ##STR1## wherein X represents naphthyl optionally substituted by alkyl or halogen; and p, q and r independently represent 2 or 3, and pharmaceutically acceptable salts thereof; processes for their preparation and methods for their ...	07/27/1999
5821256	Endothelin receptor antagonists Novel compounds of the formula I ##STR1## in which R1, R2, R3 and X have the meaning indicated in claim 1, and their salts exhibit endothelin receptor-antagonistic properties....	10/13/1998
5804601	Aromatic hydroxamic acid compounds, their production and use The present invention relates to a compound of the formula: ##STR1## wherein Ar represents an optionally substituted aromatic group; Q represents a divalent aliphatic hydrocarbon group; R1 represents hydrogen, cyano, an optionally substitu...	09/08/1998
5792765	Substituted oxazolidinones The present invention relates to new substituted oxazolidinones of the general formula (1) ##STR1## in which the substituents have the meaning indicated in the description, processes for their preparation and their use as medicaments, in particu...	08/11/1998
5763465	7-(2-aminoethyl) benzothiazolones There are disclosed compounds of formula I, Ar--CH2 CH2 --NH--CR1 R2 --X--Y I in which Ar represents a group, ##STR1## X represents a C1-12 alkylene chain optionally interrupted or terminated b...	06/09/1998
5760246	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug e...	06/02/1998
5708171	Imidazole derivatives for pharmaceutical use A compound selected from the group consisting of a compound of the formula ##STR1## having antagonist properties to histamine H3 -receptors....	01/13/1998
5648370	7-(2-aminoethyl) benzothiazolones There are disclosed compounds of formula I, Ar--CH2 CH2 --NH--CR1 R2 --X--Y I in which Ar represents a group, ##STR1## X represents a C1-12 alkylene chain optionally interrupted or terminated b...	07/15/1997
5597819	Phenothiazine cytokine inhibitors New benzothiazine derivatives corresponding to the general formula I: ##STR1## in which: X represents halogen, n represents 0, 1, or 2, B represents the following formula: ##STR2## in which: R1 & R2 together with the carbons to ...	01/28/1997
5563168	O-Benzyloxime ethers and crop protection agents containing these compounds O-Benzyloxime ethers of the formula I ##STR1## where 5 X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cy...	10/08/1996
5559113	Imidazole compounds and their therapeutic applications A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having antagonist properties to histamine H3 -receptors....	09/24/1996
5529998	Benzoxazolyl- and benzothiazolyloxazolidinones The invention relates to benzoxazolyl- and benzothiazolyloxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments....	06/25/1996
5521145	Iminothiazoline derivatives and herbicides containing them as active ingredients There is disclosed an iminothiazoline derivative of the general formula: ##STR1## wherein R1 is (halo)alkyl, (halo)alkenyl, (halo)alkynyl or the like; R2 is (halo)alkyl, optionally substituted aryl, formyl, cyano or the like; R	05/28/1996
5492925	Thienyl-and furylpyrrole insecticidal and acaricidal agents There are provided thienyl- and furylpyrrole compounds of formula I ##STR1## and their use for the control of insects and acarina. Further provided are compositions and methods comprising those compounds for the protection of plants from attack by in...	02/20/1996
5461162	Process of synthesizing n-acyl auxiliaries A process of synthesizing N-acyl auxiliary compounds is disclosed. A compound of the formula: ##STR1## is reacted with an anhydride in the presence of a lithium salt and an amine base to produce the N-acylated auxiliary....	10/24/1995
5413997	Triphenylmethane derivatives A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis....	05/09/1995
5371222	Alkoxyiminoacetamide derivatives and their use as fungicides A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R1 and R2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R3 is lower alkyl or cyclo(lower)alkyl; R4...	12/06/1994
5371223	Alkoxyiminoacetamide derivatives and their use as fungicides A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R1 and R2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R3 is lower alkyl or cyclo(lower)alkyl; R4...	12/06/1994
5356864	New herbicidal fluorobenzothiazolyloxyacetamides Novel herbicidal fluorobenzothiazolyloxyacetamides of the formula ##STR1## in which R1 represents hydrogen or an optionally substituted radical from the group consisting of alkyl, alkenyl, alkinyl and aralkyl, R2 represents an option...	10/18/1994
5258395	Thiazole compounds as inhibitors of SRS-A Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis (SRS-A)....	11/02/1993
5250690	Haloalkoxy anilide derivatives of 2-4(-heterocyclic oxyphenoxy)alkanoic or alkenoic acids and their use as herbicides The present invention is directed to novel substituted aniline compounds, the optically active isomers of said compounds, compositions containing said compounds, and the use of these compounds in the selective kill and control of grassy weeds in the prese...	10/05/1993
5248689	Substituted N-(imidazolyl)alkyl alanine derivatives Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m...	09/28/1993

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Class 548/171 - Nitrogen bonded directly to the -C(=X)- group