Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 7741490 | Intermediates for the preparation of pramipexole Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis. ... | 06/22/2010 |
| 7365086 | Pramipexole acid addition salts The benzene sulfonic acid salts of pramipexole have moderate water solubility and are useful pharmaceutical active agents. ... | 04/29/2008 |
| 7354542 | Lightweight, heat insulating, high mechanical strength shaped product and method of producing the same This invention relates to a process of a lightweight, heat insulating, high compressive strength, water insoluble material by heat treatment at temperatures between 650-950° C., possessing a low bulk density (from 300 to 800 kg/m3) and improved heat insu... | 04/08/2008 |
| 7285669 | Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole, which is useful for making pramipexole, is made by: (i) reacting bromine with a solution of 4-acetamido-cyclohexanone in water to produce 2-bromo-4-acetamido-cyclohexanone; (ii) after step (i), adding thiourea to produce... | 10/23/2007 |
| 7141595 | Amino benzothiazole compounds with NOS inhibitory activity The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are useful for treating stroke and n... | 11/28/2006 |
| 7125893 | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I in which R1a, R1b, R2a, R3a, R3b, R4, R... | 10/24/2006 |
| 7087761 | Cyclization process for substituted benzothiazole derivatives The present invention relates to a process for preparation of amino substituted benzothiazole derivatives of formula I wherein R1, R2 and R3 are independently from ea... | 08/08/2006 |
| 7022823 | Diazonium salt, its synthesizing method and recording material The present invention relates to a diazonium salt represented by the following general formula (1) and a synthesizing method thereof, as well as a recording material using the diazonium salt. In general formula (1), R1 represents a hydrogen atom, a... | 04/04/2006 |
| 6825355 | Benzothiazole protein trosine kinase inhibitors Novel benzothiazoles and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders. ... | 11/30/2004 |
| 6727367 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor A process for resolving or enriching (R,S) 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole (pramipexole) into optical isomers uses a monovalent salt thereof, e.g. pramipexole monohydrochloride, as a substrate. The monovalent salt is treated with an optically a... | 04/27/2004 |
| 6727270 | Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 04/27/2004 |
| 6699921 | Rubber composition for tire and tire using the same There is provided a rubber composition whose run-flat durability is improved and in which precipitation of sulfur and a vulcanization accelerator on the rubber surface before vulcanization is prevented. Sulfur in an amount of 2 to 8 parts by weight and tw... | 03/02/2004 |
| 6649758 | Preparation of trans-thiazineindigo pigments A process for preparing symmetrical or asymmetrical trans-thiazineindigo pigments of the formula (1) ##STR1## which comprises a) condensing, in an aqueous medium, a compound of the formula (2) with a compound of the formula (3a) or (3b) or a compound ... | 11/18/2003 |
| 6613743 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and phy... | 09/02/2003 |
| 6232498 | Process for the preparation of benzothiazolone compounds There are described processes for the preparation of a compound of formula I ##STR1## and novel intermediates in the preparative process.... | 05/15/2001 |
| 6232470 | Substituted pyrazol-3-ylbenzazoles, their use as herbicides or desiccants/defoliants, and their preparation Substituted Pyrazol-3-ylbenzazoles I ##STR1## salts thereof, and their use as herbicides or for the desiccation/defoliation of plants.... | 05/15/2001 |
| 6204278 | Anilide compounds, including use thereof in ACAT inhibitition The invention provides novel anilide compounds and pharmaceutical compositions comprising them. The invention relates to compounds of a formula: ##STR1## where Ar is an optionally-substituted aryl group; R4 and R5 are the same or differen... | 03/20/2001 |
| 6143747 | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: ##STR1## or a... | 11/07/2000 |
| 6124468 | Process for the preparation of benzothiazolone compounds There are described processes for the preparation of a compound of formula I ##STR1## and novel intermediates in the preparative process.... | 09/26/2000 |
| 6007865 | Reversing the formation of advanced glycosylation endproducts The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylatio... | 12/28/1999 |
| 6002013 | 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compound... | 12/14/1999 |
| 5986102 | Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases Compounds of Formula I are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathsepsin D. The compounds are useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I... | 11/16/1999 |
| 5968942 | - and ଲ-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors - and ଲ-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 10/19/1999 |
| 5853703 | Preventing and reversing the formation of advanced glycosylation endproducts The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylatio... | 12/29/1998 |
| 5834500 | Sulfur-containing heterocyclic bradykinin antagonists, process for their preparation, and their use Sulfur-containing heterocyclic bradykinin antagonists, process for their preparation, and their use Compounds of the formula (I) ##STR1## in which one of the radicals X1, X2 or X3 is C--O--R2 and the other ... | 11/10/1998 |
| 5795903 | 6-polyfluoroalkoxy-and 6-polyfluoroalkyl-2-aminobenzothiazole derivatives Compounds of formula (I): ##STR1## wherein R is a polyfluoroalkoxy or polyfluoroalkyl radical and R1 is a hydrogen atom and R2 is a hydroxyl radical, or R1 is a hydroxyl radical and R2 is a hydrogen atom, s... | 08/18/1998 |
| 5656261 | Preventing and reversing advanced glycosylation endproducts The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reve... | 08/12/1997 |
| 5567822 | Process for the preparation of 2-amino-7-nitrobenzo-thiazoles This invention relates to the process for the preparation of 2-amino 7-nitro benzothiazoles of formula (I) ##STR1## consisting in a) nitrating a derivative of formula (II) ##STR2## and b) reacting the compound of formula (III) ##STR3## ... | 10/22/1996 |
| 5567716 | Trans and cis traumatic acid salts having cicatrizant activity associated to bacteriostatic, antiviral, antibiotic or antifungal activity Traumatic acid salts, wherein B is a cation selected from: a) a quaternary ammonium, b) a cation of a linear or branched C1 -C20 mono-, di- or trialkanolamine, c) a cation of a biologically active primary, secondary or tertiary amine, d) silve... | 10/22/1996 |
| 5449680 | 2,2 disubstituted glycerol and glycerol-like compounds, compositions and methods of use Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also disclosed are methods of synthesizing and using the compounds... | 09/12/1995 |
| 5424439 | Process for the preparation of 2-amino-4-nitrobenzothiazole derivatives and intermediates This invention relates to the process for the preparation of a method for preparing derivatives of formula (I), ##STR1## wherein R is an alkyl, alkoxy, alkylthio, polyfluoroalkyl, polyfluoroalkoxy, alkenyl, phenyl, alkylsulphonyl, alkoxycarbonyl, ami... | 06/13/1995 |
| 5380735 | Benzothiazole derivatives and methods of use The present invention relates to a novel benzothiazole derivative of the following general formula (I) or its (E) , (Z)isomer, and processes for preparation thereof, ##STR1## in which R1, R2 and R3 independently of on... | 01/10/1995 |
| 5374737 | Process for the preparation of 2-aminobenzothiazoles A process for the preparation of a 2-aminobenzothiazol of the formula ( I ) ##STR1## in which R1 and R2 independently of each other are hydrogen, fluorine, chlorine, bromine or iodine, trifluoromethyl or C1 -C4 ... | 12/20/1994 |
| 5288749 | Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors The present invention provides tertiary and secondary amine compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof which are antagonists for alpha-2 adrenoreceptors and which inhibit serotonin (5-hydroxytryptamine, 5... | 02/22/1994 |
| 5278177 | Bicyclic heterocyclic derivatives as 5-lipoxygenase inhibitors The invention concerns a bicyclic heterocyclic derivative of the formula I ##STR1## wherein Q is an optionally substituted 9-membered bicyclic heterocyclic moiety containing 1 or 2 N's and optionally a further N, O or S heteroatom; A1 is a... | 01/11/1994 |
| 5240948 | 3-(3-alkylthiopropyl)benzothiazoline derivatives, their preparation and the medicament containing them Compounds of formula: ##STR1## in which R1 represents a polyfluoroalkoxy radical and R2 represents an alkylthio, alkylsulphinyl or alkylsulphonyl radical, their salts, their preparation and the medicaments containing them.... | 08/31/1993 |
| 5055582 | Process for preparing thromboxane A2 antagonists This invention relates to a process for preparing useful thromboxane A2 inhibiting (&#b1;)7-[3-[1-[[(phenylamino)thioxomethyl]hydrazono]ethyl]-1 ,4-bicyclo[2.2.1]hept-2ଲ-yl]-heptenoic acids and useful derivatives ... | 10/08/1991 |
| 5010198 | Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents Benzoxazol- and benzothiazolamine derivatives having anti-anoxic properties which compounds are useful in the treatment of anoxia. These compounds are produced from certain benzoxazol- and benzothizolamine intermediates.... | 04/23/1991 |
| 4987146 | N-hetaryl imidazole derivatives N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R3 represents hydrogen, a straight or branched C1-6 -alkyl group, or ... | 01/22/1991 |
| 4962040 | 2-hydrazono-4,6-dinitrobenzthiazolones useful to form dyestuffs and as color formers for detecting peroxide 2-Hydrazono-4,6-dinitrobenzthiazolones of the formula ##STR1## in which X1 represents hydrogen, C1 -C4 -alkyl, C1 -C4 -hydroxyalkyl, C1 -C4 -sulphoalkyl or C1 -C4... | 10/09/1990 |
