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| Number | Title | Issue Date |
| 7858803 | Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders The present invention relates to compounds and methods for imaging and treating Alzheimer's disease or an amyloidosis-associated pathological condition that utilize a novel amyloid imaging tracer for detecting amyloid deposits in a subject suffering from these condi... | 12/28/2010 |
| 7692021 | NPN-type low molecular aromatic ring compounds and organic semiconductors and electronic devices incorporating such compounds Disclosed herein are NPN-type low molecular aromatic ring compounds, organic semiconductor layers formed from such compounds that exhibit improved electrical stability and methods of forming such layers using solution-based processes, for example, spin coating proce... | 04/06/2010 |
| 7351807 | Cyanine-sulfenates for dual phototherapy Dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds comprise sulfenates having the formula, t,0080 where E is selected from the group consisting of somatostatin receptor binding molecules, heat se... | 04/01/2008 |
| 7270800 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds.... | 09/18/2007 |
| 7235320 | Proton-conducting membrane and use thereof The present invention relates to a novel proton-conducting polymer membrane based on polyazoles which can, because of its excellent chemical and thermal properties, be used in a variety of ways and is particularly useful as polymer electrolyte membrane (PEM) to prod... | 06/26/2007 |
| 7172907 | Cyanine dye labelling reagents with -substitution Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1): in which groups R3 and R4 are attached to the... | 02/06/2007 |
| 7112413 | Heteroaryl substituted benzothiazole dioxetanes Chemiluminescent heteroaryl substituted benzothiazole 1,2-dioxetane compounds capable of producing light energy when decomposed are provided. These chemiluminescent compounds are represented by the general formula: The... | 09/26/2006 |
| 7074840 | Light adjustable lenses capable of post-fabrication power modification via multi-photon processes The invention relates to novel photoinitiators and their use in light adjustable compositions. The initiatives comprise two or more multiphoton chromophores linked by a bridging compound. The bridging compound consists of a material that is compatible with the base ... | 07/11/2006 |
| 7045539 | Therapeutic benzoxazole compounds Compounds of the formula (I) for use as an estrogen receptor-β-selective ligand are described wherein: X is O or S; and R1, R3 R6 are as described in the specification. The use of these compounds in treating Alzheimer's disease, anx... | 05/16/2006 |
| 7025949 | In-vivo diagnostic method by means of near infrared radiation This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluoresc... | 04/11/2006 |
| 6995262 | Use of acylsulfonamido-substituted polymethine dyes as fluorescene dyes and/or markers The invention relates to a novel polymethine dyes containing at least one acylsulfonamido group of the formula (I) in which n, Y, A and R have the meaning given in the claims, and at least one compound of the formulae ... | 02/07/2006 |
| 6956032 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods The present invention pertains to luminescent dyes and methods for covalently attaching the dyes to a component or mixture of components so that the components may be detected and/or quantified by luminescence detection methods. The dyes are cyanine and cyanine-type... | 10/18/2005 |
| 6926885 | In-vivo diagnostic method by means of near infrared radiation This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluoresc... | 08/09/2005 |
| 6884891 | Methine dyes, manufacturing methods thereof, and silver halide photographic materials containing same dyes Methine dye compounds represented by formula (1) and highly sensitive silver halide photographic materials containing these compounds: Dye1-(L1-(Dye2)m1)m2 (CI1)y1 (1) wherein L1 | 04/26/2005 |
| 6867304 | Photoinitiators for two-photon induced free-radical polymerization Provided are new TPA chromophores of the formula: wherein R is an alkyl group having 1 to 20 carbon atoms and Q is —C6H13, —CH2—C6H5, or —C6H | 03/15/2005 |
| 6849742 | Binaphthol derivative and process for producing the same The present invention provides a binaphthol compound represented by formula [1]: and a salt thereof. The binaphthol compound of the present invention is useful for manufacturing antiseptic compounds or chiral catalysts... | 02/01/2005 |
| 6737532 | Organic electroluminescent materials An organic electroluminescent compound of the formula (I) wherein: X1 is selected from the group consisting of oxygen, sulfur, C(CH3)2 and N—R, wherein R is hydrogen, alkyl of fr... | 05/18/2004 |
| 6730793 | Two-photon responsive chromophores containing electron accepting core units Provided are chromophores of the formula Q—(—L—Z)x, wherein x is 2 or 3, wherein Q is selected from the group consisting of wherein L is | 05/04/2004 |
| 6716413 | Indole compounds as tissue-specific exogenous optical agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 04/06/2004 |
| 6669926 | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are usef... | 12/30/2003 |
| 6667330 | Furanone derivatives Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial i... | 12/23/2003 |
| 6660529 | Heteroaryl substituted benzothiazole dioxetanes Chemiluminescent heteroaryl substituted benzothiazole 1,2-dioxetane compounds capable of producing light energy when decomposed are provided. These chemiluminescent compounds are represented by the general formula: ##STR1## The heteroaryl substituent Y ca... | 12/09/2003 |
| 6630470 | G-CSF mimetics Invented are G-CSF mimetics. Also invented are selected octacyclic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds as G-CSF mimetics. Also invented are novel processes used in preparing these compoun... | 10/07/2003 |
| 6576780 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 06/10/2003 |
| 6552199 | Fluorescence dyes and their use as fluorescence markers The subject matter of the invention are new xanthene derivatives of the formula I, ##STR1## wherein R1,R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and X, Y, are as defined herein. The compounds according to the invention provide molecules that are--due... | 04/22/2003 |
| 6498004 | Silver halide light sensitive emulsion layer having enhanced photographic sensitivity This invention provides a photographic element comprising at least one silver halide emulsion layer in which the silver halide is sensitized with a compound of the formula (a): Ɗ-(t)m -XY' (a) XY'-(t)m -Ɗ (b) Ɗ-(t)m -XY'-(... | 12/24/2002 |
| 6451988 | Naphthol derivatives Novel naphthol derivatives, and various azo compounds and metal complexes prepared by using the derivatives are provided. The instant invention provides naphthol derivatives represented by general formula (1); ##STR1## wherein at least one of Y1 | 09/17/2002 |
| 6437141 | Cyanine dyes and synthesis methods thereof A cyanine dye having the formula ##STR1## wherein R1 -R8 are each independently selected from a group consisting of hydrogen, C1 -C6 alkyl group, and C0 -C4 alkyl group having a hydrophilic... | 08/20/2002 |
| 6420130 | Optical molecular sensors for cytochrome P450 activity The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe... | 07/16/2002 |
| 6403807 | Bridged fluorescent dyes, their preparation and their use in assays Bridged fluorescent dyes of the cyanine and squaraine families are disclosed. The dyes are useful as markers in assay techniques and offer advantages of undergoing excitation at a common wavelength but emitting at structure dependent different wavelengths... | 06/11/2002 |
| 6399392 | Xanthene dyes and their application as luminescence quenching compounds The quenching compounds of the invention are nitrogen-substituted xanthenes that are substituted by one or more aromatic or heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable fluorescence and effici... | 06/04/2002 |
| 6335450 | Efficient cyclic-bridged cyanine dyes This invention provides cyclic-bridged dyes, particularly cyclic-bridged cyanine dyes, of the general formula: ##STR1## In this formula, each dotted line represents carbon atoms necessary to form a fused substituted or unsubstituted aromatic ring; n=1-18;... | 01/01/2002 |
| 6331632 | Cyanine dye phosphoramidites This invention provides dye phosphoramidites, particularly phosphoramidites of cyanine and related dyes, of the general formula: ##STR1## In this formula, each dotted line represents carbon atoms necessary to form a fused substituted or unsubstituted arom... | 12/18/2001 |
| 6300502 | Multi-armed chromophores with very large two-photon absorption cross-sections Provided are chromophores with very large two-photon absorption cross-sections. One group of these chromophores has the formula: (T--Q)n --N--Phm wherein Q is a single bond or 1,4-phenylene, Ph is a phenyl group, n has a value of 1-3 and ... | 10/09/2001 |
| 6284924 | Compounds A novel compound represented by the general formula (1) ##STR1## or salts thereof. The compound is useful as a structural component of polymers such as polyesters and polyamides. The compound wherein Y1, Y2, Y3, and/or Y | 09/04/2001 |
| 6224644 | Cyanine dyes and synthesis methods thereof A cyanine dye having the formula ##STR1## wherein R1 -R8 are each independently selected from a group consisting of hydrogen, C1 -C6 alkyl group, and C0 -C4 alkyl group having a hydrophilic... | 05/01/2001 |
| 6225050 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods Cyanine and related dyes, such as merocyanine, styryl and oxonol dyes, are strongly light-absorbing and highly luminescent. Cyanine and related dyes having functional groups make them reactive with amine, hydroxy and sulfhydryl groups are covalently attac... | 05/01/2001 |
| 6204389 | Cyanine dyes and synthesis methods thereof A cyanine dye having the formula ##STR1## wherein R1 --R8 are each independently selected from a group consisting of hydrogen, C1 -C6 alkyl group, and C0 -C4 alkyl group having a hydrophili... | 03/20/2001 |
| 6197956 | Cyanine dyes and synthesis methods thereof A cyanine dye having the formula ##STR1## wherein R1 -R8 are each independently selected from a group consisting of hydrogen, C1 -C6 alkyl group, and C0 -C4 alkyl group having a hydrophilic... | 03/06/2001 |
| 6156772 | Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both m... | 12/05/2000 |
