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| Number | Title | Issue Date |
| 8143414 | Hepatitis C virus inhibitors This disclosure concerns novel compounds of Formula (I) or Formula (II) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded b... | 03/27/2012 |
| 8115008 | Method for producing optically active ester and method for producing optically active carboxylic acid Disclosed is a method for producing an optically active ester by highly selectively esterifying one enantiomer of a racemic carboxylic acid, while producing an optically active carboxylic acid which is the other enantiomer. An optically active ester is produced whil... | 02/14/2012 |
| 7601846 | Compounds having activity as inhibitors of apoptosis The present invention provides compounds that can protect mammalian cells from the damaging effects of chemotherapy, irradiation, or in other situations in which it is desirable to protect tissue from the consequences of clinical or environmental stress. ... | 10/13/2009 |
| 7517995 | Thiazolyl-dihydro-cyclopentapyrazole Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers... | 04/14/2009 |
| 7250429 | Aminomethyl-substituted thiazolobenzimidazole compounds This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate recepto... | 07/31/2007 |
| 7205316 | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R... | 04/17/2007 |
| 7161010 | Methine compound and silver halide photographic material containing the same Disclosed is a compound represented by the following formula (I): wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represe... | 01/09/2007 |
| 7132436 | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which act... | 11/07/2006 |
| 7022701 | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 04/04/2006 |
| 7018997 | Tricyclic 6-alkylidene-penems as β-lactamase inhibitors The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hy... | 03/28/2006 |
| 6989379 | Selective NPY (Y5) antagonists This invention is directed to triazine derivatives, bicyclic compounds and tricyclic compounds which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of... | 01/24/2006 |
| 6893650 | N2-phenylamidine derivatives The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R2 and R3, which may be the same or diff... | 05/17/2005 |
| 6864254 | Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular dis... | 03/08/2005 |
| 6858607 | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: or pharmaceutically acceptable salts or prodrugs thereof, wherein: wherein A, R1 | 02/22/2005 |
| 6770642 | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 08/03/2004 |
| 6706879 | Fluorescent dye The invention relates to fluorescent dyes. More particularly, the invention relates to fluorescent cyanine dyes, and especially to water soluble fluorescent cyanine dyes that contain additional sites for attachment to biomolecules. The invention provides a group of ... | 03/16/2004 |
| 6706744 | Glucagon antagonists/inverse agonists Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein... | 03/16/2004 |
| 6696441 | Inhibition of p53-induced stress response The present invention provides compounds that act to suppress p53 activity in mammalian cells, and a method to effectively suppress p53 activity in the cells of a mammal subject to a stress or pathology that is ameliorated by such suppression.... | 02/24/2004 |
| 6667405 | Methine compound and silver halide photographic material containing the same Disclosed is a compound represented by the following formula (I): ##STR1## wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represents an atomic group necessary to f... | 12/23/2003 |
| 6664283 | Pharmaceuticals for neurogenic pain This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention.... | 12/16/2003 |
| 6642264 | Thiazolobenzoimidazole derivatives This invention relates to novel thiazolo[3,2-a]benzoimidazole derivatives represented by the following general formula (I). The compounds provided by the invention act specifically on metabotropic glutamate receptors and are used as medicaments. The inven... | 11/04/2003 |
| 6583089 | Tricyclic benzoylcyclohexanedione derivatives Tricyclic benzoylcyclohexanedione derivatives of the formula I ##STR1## where X, Y, R1, R2, R3, R4, R5, R9, and m are defined herein, and their agriculturally useful salts. Process for prep... | 06/24/2003 |
| 6498176 | 3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors ##STR1## Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, D, X, Y and Z have the meaning as defined in the claims exhibit protein tyrosine kinase and protein serin/threonine kinase inhibitory activity.... | 12/24/2002 |
| 6387919 | Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors Compounds of formula (I): wherein X is N, CH, CCF3, or C(C1-12 aliphatic); R4 is sulfonic acid, C1-12 aliphatic-sulfonyl, sulfonyl-C1-12 aliphatic, C1-12 aliphatic-sulfonyl-C1-6 ... | 05/14/2002 |
| 6369086 | Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of prote... | 04/09/2002 |
| 6350747 | 3-(anilinomethylene) oxindoles The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of... | 02/26/2002 |
| 6268391 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases Compounds of general formula (I) wherein: R1 is H or optionally joined with R2 to form a fused ring selected from the group consisting of five to ten membered aryl, heteroaryl or heterocyclyl rings, R2 and R3 ar... | 07/31/2001 |
| 6248766 | Tricyclic compounds, their production and use A compound of the formula: ##STR1## wherein R1 is H or a substituent; m is 1-3; Ar is an aromatic group which may be substituted; X is a bond or a divalent straight-chain group having 1-6 atoms which may be substituted; Y is --S--, --O--, or ... | 06/19/2001 |
| 6245796 | Tricyclic pyrrole or pyrazole derivative A tricyclic pyrrole or pyrazole derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof, which shows strong affinity and selectivity for the 5-HT2C receptor and is useful for the treatment of c... | 06/12/2001 |
| 6225330 | Selective NPY (Y5) antagonists (tricyclics) This invention is directed to tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutic... | 05/01/2001 |
| 6222040 | Selective NPY (Y5) antagonists (tricyclics) This invention is directed to tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutic... | 04/24/2001 |
| 6197804 | 4,5-azolo-oxindoles Disclosed are novel 4,5-azolo-oxindoles having the formula ##STR1## These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. Thus, these compounds and their pharmaceutically acceptable salts, and *prodrugs of said compounds, are anti-p... | 03/06/2001 |
| 6191124 | Methanol derivatives for treatment of retroviral infections especially HIV infections The present invention relates to compounds of formula (I) which are imidazo[2,1-b]benzothiazole-3-methanol and imidazo[2,1-b]thiazole-5-methanol derivatives useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein ... | 02/20/2001 |
| 6153634 | 4,5-azolo-oxindoles Disclosed are novel 4,5-azolo-oxindoles having the formula ##STR1## These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. Thus, these compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are an... | 11/28/2000 |
| 6124331 | Selective NPY (Y5) antagonists (tricyclics) This invention is directed to tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutic... | 09/26/2000 |
| 6066658 | Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for cell differentiation induction factor action A compound represented by the formula: ##STR1## wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R1 represents an ... | 05/23/2000 |
| 6043373 | Heterocycle-fused thiazole derivatives A thiazole compound represented by general formula (I), wherein R is hydrogen atom, a hydroxy group, a straight or branched C1 -C6 lower alkyl group, a C1 -C4 lower alkoxy group, phenyl group, a phenyl group hav... | 03/28/2000 |
| 5955485 | Use of fused benzothiazoles as neuroprotectants The present invention is concerned with the method of using a 2,3-dihydro-imidazo2,1-b!benzothiazole derivative for the manufacture of a medicament for the therapeutic or prophylactic treatment of humans suffering from ageing of, or degenerative disease... | 09/21/1999 |
| 5919799 | Imidazothiazole compound An imidazothiazole compound having the formula (A): ##STR1## wherein R1 is a phenyl or napthyl which may have a substituent, R2 is an acyl, and the two bonds at dotted line portions may or may not exist simultaneously, or a phar... | 07/06/1999 |
| 5834499 | 5-HT3 receptor agonist, novel thiazole derivative and intermediate thereof A 5-HT3 receptor against containing a thiazole derivative as the effective ingredient is provided and is represented by the Formula (I): ##STR1## wherein the A ring is substituted or unsubstituted and represents a benzene or a heterocyclic... | 11/10/1998 |
