Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7799928 | Process for the preparation of irbesartan hydrochloride The present invention is concerned with a process for the preparation of 2n-butyl-4-spirocyclopentane-1-[(2′-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride, irbesartan hydrochloride, novel hydrated and anhydrous crystalline forms thereof, am... | 09/21/2010 |
| 7202251 | Bicyclic anilide spirohydantoin CGRP receptor antagonists The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache... | 04/10/2007 |
| 7199125 | Spiro-cyclic compounds useful as anti-inflammatory agents The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(═O)— or optionally substituted... | 04/03/2007 |
| 7189722 | Aryl spirohydantoin CGRP receptor antagonists The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pha... | 03/13/2007 |
| 7138483 | Monomers, conjugated polymers and electronic devices using such polymers The energy levels (HOMO, LUMO) of the conjugated polymer are tuned independently, so that an energy match on both sides of the device can be accomplished while keeping the emission color in the blue region. Such polymers can be formed by polymerization of a mixture ... | 11/21/2006 |
| 6911463 | 3-substituted oxindole β-3 agonists The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity. ... | 06/28/2005 |
| 6852548 | Benzothiazole dioxetanes Chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature, represented by the formulas I or II: wherein T is: | 02/08/2005 |
| 6822094 | Spiro compounds and their use Spiro compounds of the formula (I), in which at least one of the radicals K1, L, M, N1, R1, R2, R3, R4 is one of the following groups ... | 11/23/2004 |
| 6767864 | Heteroaryl-substituted heterocycles The present invention relates to novel compounds of the formula (I) in which A, B, W, G and Het are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and... | 07/27/2004 |
| 6683709 | Photochromic pyran compounds Photochromic pyran compounds and their use in synthetic resin objects of all types, especially for ophthalmic applications, particularly spiro compounds having a fluorene structure derived from naphthopyrans, which are known as spirofluorenopyrans. By int... | 01/27/2004 |
| 6576780 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 06/10/2003 |
| 6372912 | Process for ring cleavage of thiazolidine derivatives Process for the hydrolytic ring cleavage of thiazolidine derivatives to give 2-aminomercaptan derivatives and carbonyl compounds, which comprises bringing an aqueous solution of the thiazolidine derivative into contact with an acidic cation exchanger in the H | 04/16/2002 |
| 6365747 | Method for the preparation of citalopram The present invention relates to a method for the preparation of citalopram or any of its enantiomers and acid addition salts thereof comprising treatment of a compound of formula (IV), wherein X is O or S; R1 -R2 are each independen... | 04/02/2002 |
| 6358750 | Spiro[pyrrolidine-2,3'-oxindole] compounds and method of use The invention provides spiro[pyrrolidine-2,3'-oxindole] compounds and libraries of these compounds produced by the stereo- and regio-selective reaction of variously substituted isatins, -amino acids, and dipolarophiles (e.g., trans-chalcones, acryl... | 03/19/2002 |
| 6353006 | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and t... | 03/05/2002 |
| 6191160 | Spiro-indolines as Y5 receptor antagonists Compounds of the general structural formula I ##STR1## are selective NPY Y5 receptor antagonists. The compounds and compositions of the present invention are useful in the treatment of obesity and complications associated therewith.... | 02/20/2001 |
| 6172115 | Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering a retinoid, such as an RXR-selective retinoid, e.g. the compound of the formula: ##STR1## and pharmaceutically acceptable salts and esters and am... | 01/09/2001 |
| 6114540 | Spiro[pyrrolidine-2,3'-oxindole] compounds and methods of use The invention provides spiro[pyrrolidine-2,3'-oxindole] compounds produced by the stereo- and regio-selective reaction of variously substituted isatins, -amino acids, and dipolarophiles (e.g., trans-chalcones, acrylate esters, or vinyl oxindoles).... | 09/05/2000 |
| 6004963 | Substituted 2, 4-imidazolidinedione compounds as pharmaceutical active ingredients A substituted 2,4-imidazolidinedione compound corresponding to the formula I ##STR1## a process for production thereof and the use of these compounds in a pharmaceutical preparation are described. Substituents R1, R2, R3 and R4 have the same mea... | 12/21/1999 |
| 5994552 | Process for the production of substituted thiazoline-dioxetan substrates and use thereof Compounds of the general formula III, ##STR1## in which R represents ##STR2## and in which R1 and R2 are the same or different and represent hydrogen or straight-chained or branched lower alkyl C1 - C6... | 11/30/1999 |
| 5840217 | Spiro compounds and their use as electroluminescence materials Use of spiro compounds of the formula (I) ##STR1## where K1 and K2 are, independently of one another, conjugated systems, in electroluminescence devices. Preferred compounds of the formula (I) are 9,9'-spirobifluorene derivatives ... | 11/24/1998 |
| 5760029 | Spirocycle integrin inhibitors This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3-8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro-4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are useful as antagonists of the v ଲ | 06/02/1998 |
| 5622917 | Substituted 1H--3-aryl-pyrrolidine-2,4-dione derivatives The invention relates to new 1H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## in which A, B, X, Y and G have the meanings given in the description, to a plurality of processes for their preparation, and to their use as pes... | 04/22/1997 |
| 5618835 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.... | 04/08/1997 |
| 5597819 | Phenothiazine cytokine inhibitors New benzothiazine derivatives corresponding to the general formula I: ##STR1## in which: X represents halogen, n represents 0, 1, or 2, B represents the following formula: ##STR2## in which: R1 & R2 together with the carbons to ... | 01/28/1997 |
| 5591848 | Spiroconjugated charge-transfer dyes for optical applications New intramolecular charge-transfer organic dyes are described. The design of these molecules is based on the phenomenon of spiroconjugation, and it provides a modular approach to the preparation of unique materials with interesting optical properties. In ... | 01/07/1997 |
| 5529998 | Benzoxazolyl- and benzothiazolyloxazolidinones The invention relates to benzoxazolyl- and benzothiazolyloxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.... | 06/25/1996 |
| 5508428 | Spiro compound A compound of formula I, having antibacterial activity and a pharmaceutical composition containing the compound of formula I: ##STR1## wherein Q represents a partial structure of formula II: ##STR2## wherein all substituents are defined in the s... | 04/16/1996 |
| 5486532 | Benzospiroalkenes Compounds of formula (I): ##STR1## in which: X represents --CH2 --, --(CH2)2 --, --CH.dbd.CH--, --O--CH2 --, --S--CH2 --, --SO--CH2 -- or --SO2 --CH2 --, Y repres... | 01/23/1996 |
| 5457206 | Process for preparing intermediates to nizatidine and related compounds The present invention provides a process for preparing a 2-(aminomethyl)-4-thiazolemethanol. The compounds produced by the process of the present invention are useful for synthesizing anti-ulcer compounds such as Nizatidine.... | 10/10/1995 |
| 5455357 | Substituted thiazoline-dioxetan substrates, process for the production and use Compounds of the general formula III, ##STR1## in which R represents ##STR2## and in which R1 and R2 are the same or different and represent hydrogen or straight-chained or branched lower alkyl C1 -C6,... | 10/03/1995 |
| 5438146 | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers Triggerable dioxetanes with a fluorescent molecule containing group bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are useful in immunoassays and in probes using enzymes or other chemicals for... | 08/01/1995 |
| 5373009 | Dibenzofuranyl esters of N-heterocyclic carboxylic acids A compound of the formula: ##STR1## wherein R1 and R2 are, independently, halo, trifluoromethyl, cyano, nitro, alkyl, alkoxy, --CO2 H, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, mono- or di-alkylaminocarbonyl, o... | 12/13/1994 |
| 5344842 | Thiosemicarbazone derivatives The invention relates to novel thiosemicarbazones of formula I ##STR1## wherein R1 is lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-1-yl, R2 and R3 independently of one another are hydrogen or lower alkyl, or R | 09/06/1994 |
| 5338746 | Thiosemicarbazonic acid esters The invention relates to novel thiosemicarbazonic acid esters of formula I ##STR1## wherein R1 and R5 are lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-l-yl, R2 and R3 independently of one another are hydro... | 08/16/1994 |
| 5334725 | 2-aminomethyl-4-exomethylenethiazoline epoxides The present invention provides a novel process for preparing a 2-(aminomethyl)-4-thiazolemethanol. The compounds produced by the process of the present invention are useful for synthesizing anti-ulcer compounds such as Nizatidine.... | 08/02/1994 |
| 5329006 | Chromogenic lactam compounds, their preparation and their use Chromogenic lactam compounds of the formula ##STR1## in which the ring A is an aromatic or heteroaromatic radical which has 6 ring atoms and may contain a fused aromatic ring, it being possible for both the ring A and the fused ring to be substituted... | 07/12/1994 |
| 5288722 | 6-amino-6-desoxyfumagillols, production and use thereof The present invention relates to a compound of the formula: ##STR1## wherein R1 is 2-methyl-1-propenyl group or isobutyl group; R2 and R3 are each hydrogen atom, an optionally substituted hydrocarbon residue or an opt... | 02/22/1994 |
| 5276159 | Dynemicin analogs: syntheses, methods of preparation and use A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting prope... | 01/04/1994 |
| 5270317 | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present The invention relates to N-substituted heterocyclic derivatives and its salts. These derivatives have the formula ##STR1## in which the substituents are as defined in the specification. Application: Angiotensin II antagonists... | 12/14/1993 |
