Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7851635 | Mitotic kinesin inhibitor A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a h... | 12/14/2010 |
| 7425636 | Thiadiazoline derivative (wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alken... | 09/16/2008 |
| 7408068 | Compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R3, R5, R7, U, X, Y and Z are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. Thi... | 08/05/2008 |
| 7390908 | Compounds effecting glucokinase The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or preventio... | 06/24/2008 |
| 7253195 | Compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R3, R5, R7, U, X, Y and Z are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-p... | 08/07/2007 |
| 7232820 | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R3, R5, R7, X, Y and U are as defined. Compounds of the Formula I have activity inhibiting produ... | 06/19/2007 |
| 7053220 | Hydroxyalkanoyl aminopyrazoles and related compounds This invention is directed to a class of compounds (Formula I) including hydroxyalkanoyl amino pyrazoles, hydroxyalkanoyl amino thiadiazoles, hydroxyalkanoyl amino acid esters, hydroxyalkanoyl amino acid amides, hydroxyalkanoyl amino alcohols, hydroxyalkanoyl amino ... | 05/30/2006 |
| 7045544 | Substituted 2,5-diamidoindoles as ECE inhibitors for the treatment of cardiovascular diseases The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals ... | 05/16/2006 |
| 6951945 | Heteroaromatic glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the ... | 10/04/2005 |
| 6903104 | Indol-3-YL-2-oxoacetamide compounds and methods of use thereof The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following formula. In this formul... | 06/07/2005 |
| 6890942 | Acyl sulfonamides as inhibitors of HIV integrase The present invention relates a series of compounds of Formula I wherein R1, R2, R3, and B are as defined in the specification. The compounds are useful for the inhibition of HIV integr... | 05/10/2005 |
| 6881844 | Indole-3-carboxamides as glucokinase activators The present invention provides glucokinase activators of formula I: wherein R1, R2 and R3 are defined in the specification. Glucokinase activators are useful for increasing insulin secr... | 04/19/2005 |
| 6852752 | Urea compounds, compositions and methods of use and preparation Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.... | 02/08/2005 |
| 6780995 | Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer... | 08/24/2004 |
| 6632817 | Fluoromethoximino compounds The invention relates to novel fluoromethoximino compounds, to a process for their preparation and to their use as pesticides, and also to novel intermediates and to a plurality of processes for their preparation.... | 10/14/2003 |
| 6511988 | Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preven... | 01/28/2003 |
| 6506738 | Benzimidazolone antiviral agents The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazolone derivatives for the treatment of respiratory syncytial virus infection.... | 01/14/2003 |
| 6352985 | Benzimidazole compounds A benzimidazole compound represented by the formula (I): ##STR1## wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable... | 03/05/2002 |
| 6320050 | Heteroaromatic glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in ... | 11/20/2001 |
| 6306871 | Activated iododerivatives for the treatment of cancer and AIDS A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preven... | 10/23/2001 |
| 6239152 | Oxazolidinone combinatorial libraries, compositions and methods of preparation Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as ph... | 05/29/2001 |
| 6225323 | Activated iododerivatives for the treatment of cancer and AIDS A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preven... | 05/01/2001 |
| 6150385 | 1,3,4-thiadiazoles useful for the treatment of CMV infections The present invention presents novel 1,3,4-thiadiazole derivatives of formula I ##STR1## which have useful antiviral activity against herpes virus, cytomegalovirus (CMV).... | 11/21/2000 |
| 5977149 | Dihydrotriazole compounds and their use for controlling fungal plant diseases Cyclic amides of Formula (I) which are useful as fungicides wherein: A is O; S; N; NR5 ;or CR14--, G is C or N; W is O or S; X is OR1, S(O)m R1 or halogen; R1, R2, and R5 a... | 11/02/1999 |
| 5977373 | Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents The present invention provides thiadiazolyl and oxadiazolyl phenyl oxzolidinone compounds of formula I ##STR1## wherein Q is thiadiazolyl or oxadiazolyl; wherein X1 and X2 are independently hydrogen, fluorine or chlorine; and wh... | 11/02/1999 |
| 5965738 | Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same Described is a process for producing an N-biphenyl-methylthiadiazoline derivative (7) in accordance with the reaction formula described below. According to the process of the present invention, it is possible to produce a compound (7) advantageously from ... | 10/12/1999 |
| 5912353 | Process for producing tetrazolylated biphenylmethane derivatives The present invention relates to a process for producing a tetrazolylated biphenylmethane derivatives (6) or salts thereof in accordance with the below-described reaction scheme wherein R1 represents an alkyl; R2 represents H, etc.; ... | 06/15/1999 |
| 5912258 | Thiadiazoleamide derivative and anti-ulcer drug A thiadiazoleamide derivative or a salt thereof expressed by the following Formula 1: ##STR1## wherein each of R1 and R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylamino group or an ... | 06/15/1999 |
| 5847149 | Thiadiazole derivatives, process for their preparation, and their use as precursors for the production of liquid crystals Thiadiazole derivatives of the formula (I) X-B-A1 -(M1 -A2 -)m (M2 -A3)n -R1(I ) in which the symbols and indices have the following meanings: X is Cl, Br or I; B is 1,3,4-thiadi... | 12/08/1998 |
| 5830869 | Thiadiazole amide MMP inhibitors The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are ... | 11/03/1998 |
| 5747514 | Metalloproteinase inhibitors The present invention relates to therapeutically active hydroxamic acid and carboxylic acid derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to the use of such compounds in medicine. In particular, the c... | 05/05/1998 |
| 5677282 | Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase Amino acid amides of 5-amino-1,3,4-thiadiazole-2-thione are disclosed. These compounds inhibit matrix metalloproteinase enzymes and cartilage degradation. Methods of treating diseases caused by over-activity of matrix metalloproteinases, such as osteoarth... | 10/14/1997 |
| 5627198 | Heterocyclic amides The invention relates to heterocyclic amides of the formula ##STR1## in which the radicals A, Z, A1, R1, R2 and R3 are as defined in the description, to a process for the preparation of these amides and to ... | 05/06/1997 |
| 5538991 | Endothelin antagonists bearing 5-membered heterocyclic amides Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral... | 07/23/1996 |
| 5516442 | Polymeric thioheterocyclic rust and corrosion inhibiting marine diesel engine lubricant additives A rust and corrosion inhibiting marine diesel engine lubricating oil additive is provided which comprises a mixture of: (a) an oligomeric polythiocyclic imide represented by the formula ##STR1## wherein R and R1 each are a (C1 -C | 05/14/1996 |
| 5457122 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, possess an antagonistic activity on leukotriene B4.... | 10/10/1995 |
| 5412117 | Benzopyran derivatives Benzopyran derivatives represented by formula (I): ##STR1## wherein X represents =O, =S, =N-Z (Z represents a lower alkyl group, etc.), or =CHNO2 ; Y represents a substituted amino group, an alkoxy group, an alkylthio group, etc., and R | 05/02/1995 |
| 5401853 | Thiadiazole derivatives for the treatment of depressive states Thiadiazole derivatives of general formula (I) ##STR1## wherein R1 is selected from the class consisting of: C1 -C10 linear or branched alkyl, benzyl, optionally substituted at the aromatic ring with one or more group... | 03/28/1995 |
| 5350856 | 2-(substituted imino)-1,3,4-dihydrothiadiazoles This invention relates to a process for producing a compound of the formula ##STR1## comprising reacting a compound having the formula ##STR2## with cyanogen chloride or cyanogen bromide.... | 09/27/1994 |
| 5344927 | Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same A tetrahydrobenzimidazole derivative represented by formula (I): ##STR1## wherein Het represents a heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, ... | 09/06/1994 |
