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| Number | Title | Issue Date |
| 7737283 | Anti-inflammatory medicaments Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel com... | 06/15/2010 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7432292 | Sulfhydantoins as phosphate isosteres The present invention relates to novel phosphate isosteres. The invention relates to compounds having a sulfhydantoin or a reverse sulfhydantoin moiety, uses thereof, and related methods. The present invention relates to compounds of formula I or II: | 10/07/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7338968 | Thiadiazoles AS CXC- and CC- chemokine receptor ligands Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl... | 03/04/2008 |
| 7291635 | 5-substituted 1,1-dioxo-1,2,5,-thiadiazolidin-3-one derivatives Compounds of the formula provide pharmacological agents which are inhibitors of PTPases, in particular, the compounds of formula I inhibit PTP-1B and TC PTP, and thus may be employed for the treatment of conditio... | 11/06/2007 |
| 7253202 | Substituted benzodioxepines Benzodioxepines of the formula (I) and physiologically tolerated salts and solvates thereof, in which R1, R2, R3, R4, A, B, a and b have the meanings indicated in claim 1, are ligands of the 5HT1A receptors and/or the 5HT4... | 08/07/2007 |
| 7160909 | Cyclopenta[b]indole derivatives as sPLAinhibitors A novel class of tricyclic compounds of the following formula (I) is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock. ... | 01/09/2007 |
| 7125869 | Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the field... | 10/24/2006 |
| 7108948 | Organophotoreceptor with charge transport compositions An organophotoreceptor comprises an electrically conductive substrate and photoconductive element on the electrically conductive substrate, the photoconductive element having a) a charge transport composition with the formula ... | 09/19/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 6987104 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in th... | 01/17/2006 |
| 6720342 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azabicyclic compounds, a method of preparing the same and to pharmaceutical or veterinary compositions comprising the compounds. The novel compounds are useful in treating a disease in the central nervous syste... | 04/13/2004 |
| 6617339 | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described.... | 09/09/2003 |
| 6559171 | 7-oxo-2-azabicyclo[2.2.1]heptanes as selective muscarinic receptor antagonist The present invention relates to muscarinic receptor modulators, specifically, 7-oxo-2-azabicyclo[2.2.1]heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, p... | 05/06/2003 |
| 6537948 | Uracil compounds and use thereof The present invention relates to an uracil compound of the formula [I]: ##STR1## [wherein, Q--R3 represents a R3 -substituted group of a 5-membered or 6-membered heterocyclic ring having one or two nitrogen selected from the group co... | 03/25/2003 |
| 6395762 | Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists This invention provides compounds of Formula I having the structure ##STR1## wherein, ##STR2## R1, R2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting ... | 05/28/2002 |
| 6331537 | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodengenerative diseases, for treating alopecia and pr... | 12/18/2001 |
| 6300325 | IL-8 receptor antagonists This invention relates to novel benzo-2-triazole substituted compounds, pharmaceutical compositions, processes for their preparation, and use thereof in treating IL-8, GRO, GROଲ, GROγ and NAP-2 mediated diseases.... | 10/09/2001 |
| 6187798 | Heterocyclic compounds The present invention provides aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic receptor.... | 02/13/2001 |
| 6130225 | Substituted p-trifluoromethylphenyluracils The invention relates to novel substituted p-trifluoromethylphenyluracils of the general formula (I) in which R1, R2, R3, R4 and R5 are each as defined in the description, to a process for their prepa... | 10/10/2000 |
| 6124312 | Heterocyclic compounds The present invention provides heterocyclic 2-aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic ptor.... | 09/26/2000 |
| 6100252 | Heterocyclic compounds and their use as angiotensin antagonists | 08/08/2000 |
| 6069159 | Heterocyclic compounds The present invention provides heterocyclic compounds which are useful for modulating a muscarinic receptor.... | 05/30/2000 |
| 6040442 | Process for preparing 1,2,5-thiadiazole containing ethers The presently claimed process provides a method for preparing compounds of the formula ##STR1## phosphorous (III) compound and a diester of azodicarboxylate.... | 03/21/2000 |
| 6022868 | Substituted azacyclic or azabicyclic compounds Disclosed are compounds of formula (I) selected from the following ##STR1## wherein Y is ##STR2## and wherein A, B, C, D, R, k, m, n, o, p, s, t and u are as defined in the specification. These compounds are useful in treating diseases in the ... | 02/08/2000 |
| 6015813 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azabicyclic compounds of formula I ##STR1## wherein X, R1, R2, R3, Ar, m and n are defined in the description, a method of preparing the same and to pharmaceutic... | 01/18/2000 |
| 5977129 | Azacyclic and azabicyclic substituted oxa- or thia-diazole compounds The present invention relates to compounds of formula I: wherein one or both G is an azacyclic ring of formula II: ##STR1## and Z is oxygen or sulfur and the remaining variables are as defined in the specification. The compounds are useful as stimulants o... | 11/02/1999 |
| 5972978 | Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their... | 10/26/1999 |
| 5948916 | Arylthiadiazole derivative and antiviral agent containing the same Novel arylthiadiazole derivatives and salts thereof useful for preventing and treating human viral infection and a novel virucide which contains the arylthiadiazole derivative or a salt thereof are provided. N,N-dimethyl 3-(3-(amino-2,6-dichlorophenyl)-... | 09/07/1999 |
| 5929247 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 07/27/1999 |
| 5919809 | 3-substituted-2-oxindole derivatives This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the pharmaceutically-acceptable salts thereof which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynt... | 07/06/1999 |
| 5914338 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azatricyclic compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a disease... | 06/22/1999 |
| 5821370 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 10/13/1998 |
| 5821371 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 10/13/1998 |
| 5767280 | Process for making heterocyclic compounds The present invention relates to a process for making intermediates useful for preparing therapeutically active azacyclic or azabicyclic compounds.... | 06/16/1998 |
| 5760222 | Thiadiazole dioxide derived oxaziridines as bleaching compounds Bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are thiadiazole dioxide derived mono- and di- oxaziridines. Substrates such as fabrics may be bleached in an aqueous so... | 06/02/1998 |
| 5747514 | Metalloproteinase inhibitors The present invention relates to therapeutically active hydroxamic acid and carboxylic acid derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to the use of such compounds in medicine. In particular, the c... | 05/05/1998 |
| 5731441 | Hydroxamic acid derivatives with tricyclic substitution The invention provides hydroxamic acid derivatives of the general formula ##STR1## wherein R1 represents cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; R2 represents a saturated 5- to 8-membered monocyclic or bridged N-hete... | 03/24/1998 |
| 5719170 | Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparations Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the given meaning. The compounds are pharmacologically active and may therefore be used as pharmaceuticals, in particular for treating diabetes and other diseases ... | 02/17/1998 |
