Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7982047 | Derivatives of 1,3-diones having a herbicidal activity A description follows of 1,3-diones having general formula (I): together with their use as herbicides for the control of weeds in agricultural crops. ... | 07/19/2011 |
| 7572920 | Benzimidazole derivative and use as a II receptor antagonist The present invention relates to a compound represented by the formula (I) wherein R1 is a group represented by the formula wherein R2, R3, R... | 08/11/2009 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7390804 | N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity aga... | 06/24/2008 |
| 7351726 | Substituted oxadiazolidinediones The present invention relates generally to substituted oxadiazolidinediones and methods of using them. ... | 04/01/2008 |
| 7342039 | Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them. ... | 03/11/2008 |
| 7309711 | Fungicidal agent combinations The invention relates to novel fungicidallly active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and the active compounds listed in the disclosure. ... | 12/18/2007 |
| 7157584 | Benzimidazole derivative and use thereof The present invention relates to a compound represented by the formula (I) wherein R1 is a group represented by the formula wherein R2,... | 01/02/2007 |
| 7153848 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 12/26/2006 |
| 7151175 | Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suit... | 12/19/2006 |
| 7144908 | Agonists of beta-adrenoceptors The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. | 12/05/2006 |
| 7141672 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. ... | 11/28/2006 |
| 7141592 | Substituted oxadiazolidinediones The present invention relates generally to substituted oxadiazolidinediones and methods of using them. ... | 11/28/2006 |
| 7115639 | Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in... | 10/03/2006 |
| 7078424 | N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating... | 07/18/2006 |
| 7053110 | Heterocyclic aromatic compounds useful as growth hormone secreagogues Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocyclic a... | 05/30/2006 |
| 6960604 | Thyroid receptor ligands The invention provides thiazolidinedione, oxadiazolidinedione, and triazolone compounds of Formula (I) which compounds are thyroid receptor ligands. The invention further provides pharmaceutical compositions and kits com... | 11/01/2005 |
| 6746989 | Substituted benzoylpyrazoles as herbicides The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which n represents the numbers 0, 1, 2 or 3, A represents a single bond or represents alkanediyl(alkylene), ... | 06/08/2004 |
| 6737383 | Herbicidal oxadiazolidines Compounds of Formula (1) and processes for their preparation, their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein Q, X1, X2, X3, R1, R2, ... | 05/18/2004 |
| 6699896 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds having the structure ##STR1## wherein A is OR5, or ##STR2## R1 is alkyl, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl, ##STR3## R2 is H, alkyl, or aryl; R3 | 03/02/2004 |
| 6576632 | Biaryl compounds useful as anticancer agents The present invention relates to compounds of formula I ##STR1## and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b,... | 06/10/2003 |
| 6544931 | Substituted heteroaryloxyacetanilides and their use as herbicides The invention relates to novel substituted heteroaryloxyacetanilides of the general formula (I), ##STR1## in which n, R, X, and Z are to intermediates for their preparation and to their use as herbicides.... | 04/08/2003 |
| 6531485 | Prostaglandin agonists This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 03/11/2003 |
| 6521650 | Amines as pharmaceutical agents Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorder... | 02/18/2003 |
| 6518289 | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic... | 02/11/2003 |
| 6506738 | Benzimidazolone antiviral agents The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazolone derivatives for the treatment of respiratory syncytial virus infection.... | 01/14/2003 |
| 6472414 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters... | 10/29/2002 |
| 6436974 | Amino heterocycles useful as pharmaceutical agents The instant invention is a novel series of amino heterocycles useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, and sleep dis... | 08/20/2002 |
| 6380430 | Biphenyl derivatives Novel compounds of the formula I ##STR1## in which X, R1, R2, R3, R4 and R5 have the meaning indicated in Patent Claim 1, are inhibitors of the coagulation factor Xa and can be employed for the prophy... | 04/30/2002 |
| 6365611 | Pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same ##STR1## The invention relates to novel compounds derived from pentaerythrite compounds of formula (XII) and (XVI), which can be used as pharmaceutically active substances, specially in the treatment of cardiac and circulatory diseases.... | 04/02/2002 |
| 6331537 | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodengenerative diseases, for treating alopecia and pr... | 12/18/2001 |
| 6313294 | Process for preparing amides The present invention provides a process for preparing an amide, which comprises reacting an amine with an ester in a molten form in the absence of a solvent.... | 11/06/2001 |
| 6306855 | Fluoromethoximino compounds The invention relates to novel fluoromethoximino compounds, to a process for their preparation and to their use as pesticides, and also to novel intermediates and to a plurality of processes for their preparation.... | 10/23/2001 |
| 6288236 | Benzimidazole compounds containing a benzoxazole or benzothiazole ring, and compositions and methods of use containing the same Benzimidazole compounds represented by the formula set out below and analogs thereof, wherein Y represents a single bond or sulfur atom; Z represents oxygen atom, sulfur atom, or N--R4 ; R1 and R2 independently represent h... | 09/11/2001 |
| 6288096 | Thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives Novel thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives, process for their manufacture, pharmaceutical preparations containing them and the use of the compounds in conditions associated with insulin resistance.... | 09/11/2001 |
| 6258751 | Substituted triazoles imidazoles and pyrazoles as herbicides The present invention relates to novel heterocyclic compounds and their agronomically suitable salts, methods for the use of these compounds in controlling unwanted plant species, and the use of herbicidal compositions containing these compounds. In parti... | 07/10/2001 |
| 6211197 | Prostaglandin receptor ligands Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II: Ar1 --W--Ar2 --X--Q II The compounds of the invention are str... | 04/03/2001 |
| 6200997 | Heterocyclyl-substituted phenyl compounds, processes and intermediates for their preparation and their use for controlling harmful fungi and animal pests The present invention relates to heterocyclyl-substituted phenyl compounds of the formula I, ##STR1## where the substituents have the following meanings: Y is halogen, C1 -C4 -alkyl, C1 -C4 -haloalkyl or C1... | 03/13/2001 |
| 6153759 | Heterocyclic benzoyl intermediates for herbicidal compounds Heterocyclic substituted benzoyl derivatives of the formula ##STR1## where Z is a 5-membered or 6-membered heterocyclic, saturated or unsaturated radical containing one to three hetero atoms selected from the group consisting of oxygen, sulfur and ni... | 11/28/2000 |
| 6136830 | Sulphonyloxadiazolones and their use as microbicides Novel sulphonyloxadiazolones of the formula ##STR1## in which A represents oxygen, sulphur, --SO--, --SO2 -- or ##STR2## where R3 represents hydrogen or alkyl, R1 represents optionally substituted cycloalkyl, optiona... | 10/24/2000 |
