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| Number | Title | Issue Date |
| 7960556 | Thiadiazole derivatives for the treatment of neuro-degenerative diseases The invention provides novel 1,2,4-thiadiazole derivatives useful for preventing or treating an α-synucleopathy such as Parkinson's disease, as well as pharmaceutical compositions including them as biologically active ingredients, and methods for manufacturing them... | 06/14/2011 |
| 7825256 | Inducible nitric oxide synthase dimerization inhibitors The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, X, and Y are independently s... | 11/02/2010 |
| 7786311 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological ... | 08/31/2010 |
| 7553973 | Pharmaceutical compounds The instant invention provides compounds of Formula Ia which are leukotriene biosynthesis inhibitors. Compounds of Formula Ia are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprot... | 06/30/2009 |
| 7442760 | Electroactive polymers Electroactive polymeric arylenes and intermediates useful for making such polymers are disclosed. The present invention also provides electroactive compositions comprising the electroactive polymeric arylenes, organic electronic devices which comprise these polymers... | 10/28/2008 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7414142 | 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators Compounds of formula I, wherein R1-R9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds are provided. Also provided are methods of inducing contraception, prov... | 08/19/2008 |
| 7407976 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to meth... | 08/05/2008 |
| 7399765 | Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute... | 07/15/2008 |
| 7375123 | 1,2,4-thiadiazole derivatives as melanocortin receptor modulators The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disor... | 05/20/2008 |
| 7371746 | 1,2,4-Thiadiazole compounds and pests controlling composition containing the same The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene optionally substituted with one to four of R2?, C4-C7 straight alkenylene o... | 05/13/2008 |
| 7361675 | 1,2,4-thiadiazole compounds and use thereof 1,2,4-Thiadiazole compounds represented by the formula (1) have excellent control activities against harmful arthropods: wherein R1 represents C3-C7 alkynyl group optionally substituted one or more halogen atom(s... | 04/22/2008 |
| 7361769 | Heterocyclyls as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders The present invention discloses compounds of formula I wherein m, n, p, R1, R2 and X, are herein defined, the compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as metho... | 04/22/2008 |
| 7358265 | Oxa-and thiadiazoles and their use as metalloproteinase inhibitors Compounds formula (IA) or (IB), wherein W represents HO(C═O)—, HONH(C═O)— or H(C═O)N(OH)—; X represents —O— or —S—; and R1, R2, and R3 are as defined in the description and claims, are inhibitors of matrix metallo... | 04/15/2008 |
| 7345009 | Substituted 4-hetaryl-pyrazolines as pest control agents The present invention relates to novel substituted pyrazolines of the formula (I) in which R1, R2, R3 and R4 are as defined in the disclosure, to a plural... | 03/18/2008 |
| 7342031 | Thiadiazole compound and use thereof The thiadiazole compound represented by the formula (A): wherein R1 represents a C1-C7 alkyl group, a C3-C7 alkenyl group, a C3-C7 alkynyl group and the like; R2 represents a C1-C4 alkyl group substituted with a ... | 03/11/2008 |
| 7319107 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological ... | 01/15/2008 |
| 7316851 | Electroluminescent material, electroluminescent element and color conversion filter An electroluminescent element is disclosed, comprising an electroluminescent material and a fluorescent substance emitting light having an emission maximum at the wavelength different from that of light emitted from the electroluminescent material upon absorption of... | 01/08/2008 |
| 7314875 | Tricyclic aromatic and bis-phenyl sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith. ... | 01/01/2008 |
| 7291744 | N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity The present application describes modulators of chemokine receptors of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 11/06/2007 |
| 7282512 | Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, inclu... | 10/16/2007 |
| 7271406 | Electron transport agents for organic electronic devices Compounds and compositions are provided that can be used as electron transport agents in organic electronic devices such as organic electroluminescent devices. The compounds are non-polymeric and have an aromatic core conjugated to end capping groups. The aromatic c... | 09/18/2007 |
| 7253195 | Compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R3, R5, R7, U, X, Y and Z are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-p... | 08/07/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7173030 | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and fo... | 02/06/2007 |
| 7166010 | Buffer layers for organic electroluminescent devices and methods of manufacture and use Organic electroluminescent device can be formed with multiple layers including an electrode, an emission layer, and a buffer layer. The emission layer includes a light emitting material. The buffer layer is disposed between and in electrical communication with the e... | 01/23/2007 |
| 7148219 | Biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety th... | 12/12/2006 |
| 7115639 | Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in... | 10/03/2006 |
| 7105471 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulph... | 09/12/2006 |
| 7098325 | Process for the sulfurization of a phosphorus-containing compound The invention relates to a process for the sulfurization of phosphorus-containing compounds which comprises contacting the phosphorus compound to be sulfurized with a sulfur transfer reagent of formula (I) wherei... | 08/29/2006 |
| 7094902 | Electroactive polymers Electroactive polymeric arylenes and intermediates useful for making such polymers are disclosed. The present invention also provides electroactive compositions comprising the electroactive polymeric arylenes, organic electronic devices which comprise these polymers... | 08/22/2006 |
| 7078403 | Antiviral agents Disclosed herein are compounds of formula II: wherein Alk, Z, X1, X2, R1, —R10 and R11 are defined herein, and their salts and pharmaceutically acceptable deriva... | 07/18/2006 |
| 7078424 | N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating... | 07/18/2006 |
| 7056932 | Heterocyclyl substituted 1-alkoxy acetic acid amides The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as ... | 06/06/2006 |
| 7049331 | 1,2,4-thiadiazole derivatives as melanocortin receptor modulators The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disor... | 05/23/2006 |
| 7015329 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 03/21/2006 |
| 6987104 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in th... | 01/17/2006 |
| 6974829 | Succinoyl aminopyrazoles and related compounds This invention is directed to a class of compounds (Formula I) including succinoyl amino pyrazoles, succinoyl amino thiadiazoles, succinoyl amino acid esters, succinoyl amino acid amides, succinoyl amino alcohols, succinoyl amino ketones, succinoyl amino hydantoins,... | 12/13/2005 |
| 6951945 | Heteroaromatic glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the ... | 10/04/2005 |
