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| Number | Title | Issue Date |
| 8143413 | Polycationized phospholipid derivatives The present invention provides novel phospholipid derivatives. Furthermore, the present invention provides lipid membrane structures excellent in gene/nucleic acid introduction efficiency into a cell. ... | 03/27/2012 |
| 7910744 | Method for the manufacture of substituted phosphanes, and substituted phosphanes manufactured according to said method The invention relates to a method for the manufacture of substituted phosphanes and substituted phosphanes manufactured according to the method. Phosphanes, phosphane oxides, sulfides or selenides are used as ligands in coordination compounds. They play a central ro... | 03/22/2011 |
| 7872144 | Process for producing biphosphonic acids and forms thereof Disclosed herein is a process for producing bisphosphonic acids and salts thereof. The process comprising reacting a carboxylic acid of Formula [I] with phosphorous acid and halophosphorus compound in the presence of a solvent selected from aliphatic hydrocarbon or ... | 01/18/2011 |
| 7803949 | Process for preparation of water-soluble azole prodrugs An object of the present invention is to provide a process, or the like, suitable for the industrialization of effective deprotection reaction without using a toxic solvent as well as to provide a process, or the like, for preparing a water-soluble azole prodrug eff... | 09/28/2010 |
| 7772402 | Optically detectable organophosphonates The invention relates to compounds having general formula I in which X represents an optically detectable moiety, n is an integer with 1≦n≦20, R1 is an unbranched or branched alkyl group having 1 to 20 carbon... | 08/10/2010 |
| 7687636 | Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation The invention relates to polymorphs of zoledronic acid and zoledronate sodium salts, amorphous zoledronate sodium salt, processes for making the polymorphs and amorphous zoledronate sodium salt, and pharmaceutical compositions containing the polymorphs and amorphous... | 03/30/2010 |
| 7601845 | Optically detectable organophosphonates The invention relates to compounds having general formula I in which X represents an optically detectable moiety, n is an integer with 1≦n≦20, R1 is an unbranched or branched alkyl group having 1 to 20 carbon... | 10/13/2009 |
| 7589211 | Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation The invention relates to polymorphs of zoledronic acid and zoledronate sodium salts, amorphous zoledronate sodium salt, processes for making the polymorphs and amorphous zoledronate sodium salt, and pharmaceutical compositions containing the polymorphs and amorphous... | 09/15/2009 |
| 7582768 | Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation The invention relates to polymorphs of zoledronic acid and zoledronate sodium salts, amorphous zoledronate sodium salt, processes for making the polymorphs and amorphous zoledronate sodium salt, and pharmaceutical compositions containing the polymorphs and amorphous... | 09/01/2009 |
| 7435827 | Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation The invention relates to polymorphs of zoledronic acid and zoledronate sodium salts, amorphous zoledronate sodium salt, processes for making the polymorphs and amorphous zoledronate sodium salt, and pharmaceutical compositions containing the polymorphs and amorphous... | 10/14/2008 |
| 7427636 | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such comp... | 09/23/2008 |
| 7410956 | Caspase inhibitor prodrugs The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. ... | 08/12/2008 |
| 7361761 | Process for the preparation of bisphosphonic acid The present invention is to relate an improved process using anisole as solvent for the preparation of compound of formula (I) and its pharmaceutically acceptable salts thereof. wherein R represents —NR1R2... | 04/22/2008 |
| 7361786 | Bisphosphines as bidentate ligands The present invention relates to ligands of the general formula (I). In addition, a process for the production thereof and the use thereof are demonstrated. ... | 04/22/2008 |
| 7332603 | Preparation of biphosphonic acids and salts thereof A process for preparing alendronate sodium includes the reaction of gammabutyric acid with phosphorous acid and phosphorus trichioride and subsequent treatment with an aqueous solution of an alkali metal hydroxide, in which the reaction is conducted in liquid ionic ... | 02/19/2008 |
| 7329758 | Imidazolidine-based metal carbene metathesis catalysts The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are of the formula wherein: | 02/12/2008 |
| 7323572 | Process for controlling the hydrate mix of a compound This invention relates to a process for controlling the hydrate mix of a compound, or a composition comprising the compound, the compound being capable of forming a plurality of hydration forms of differing stability and also of dissolution to give a solution that, ... | 01/29/2008 |
| 7312219 | Heteroaromatic inhibitors of fructose 1,6-bisphosphatase Novel FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 12/25/2007 |
| 7304163 | Benzotriazole-1-yl-N-oxy phosphonium coupling agent Novel phosphonium salts of benzotraizoles, which are highly reactive coupling agents, and are particularly useful in peptide synthesis, are disclosed. Further disclosed is a process of preparing the novel phosphonium salts and methods utilizing same for preparing pe... | 12/04/2007 |
| 7253154 | Substituted thiazolopyrimidines as xanthine oxidase inhibitors The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which m... | 08/07/2007 |
| 7241790 | Compounds active in spinigosine 1-phosphate signaling The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure of Formula (I) wherein R | 07/10/2007 |
| 7235666 | Process for the preparation of sodium fosphenytoin Phosphoric acid diester 2,5-dioxo-4,4-diphenylimidazolidin-1-ylmethyl esters, both of whose ester groups can be selectively cleaved, are obtained by converting 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione to an alkylsulfonate or arylsulfonate and reacting t... | 06/26/2007 |
| 7205404 | Phosphorus-containing prodrugs Novel cyclic phosphoramidate prodrugs of drugs of formula I in their use in delivery of drugs to the liver, their use in enhancing oral bioavailability, and their method of preparation are described. ... | 04/17/2007 |
| 7141672 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. ... | 11/28/2006 |
| 7125840 | Substituted dipeptides as growth hormone secretagogues This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in thes... | 10/24/2006 |
| 7112684 | Compounds and methods for fluorescent labeling Dye reagents useful in labeling biological materials are provided along with methods for their use. ... | 09/26/2006 |
| 7109186 | HIV integrase inhibitors The present invention describes novel compounds of Formula I which inhibit HIV integrase. The invention also describes compositions and treatments of AIDS or ARC by using these compounds ... | 09/19/2006 |
| 7081536 | Isoxazoline derivatives as P N ligands The invention relates to novel ligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of formula I and ... | 07/25/2006 |
| 7045634 | Prostamide receptor antagonists The present invention provides prostamide receptor antagonist compounds that may be represented by the general formula I. wherein A, R1, R2, R3, R4 and R6 ar... | 05/16/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 6977302 | Triazole derivatives useful in therapy The invention provides compounds of formula I, R1—OP(O)(OH)2 I wherein R1 represents the non-hydroxy portion of a triazole antifungal compound of the type comprising a tertiary hydroxy group; or a pharmaceu... | 12/20/2005 |
| 6951944 | Production of imidazole derivatives and novel intermediates of the derivatives An improvement in the production of imidazole derivatives including histamine H3 agonist immepip and histamine H3 antagonist VUF4929. Desired imidazole derivatives can be easily obtained in high yield by using novel intermediates represented by... | 10/04/2005 |
| 6921764 | Thieno-pyrimidin-4-one AMPA antagonists The present invention relates to novel quinazolin-4-one derivatives of the formula I, as defined in the specification, pharmaceutical compositions containing such compounds the use of such compounds to treat neurodegenerative, psychotropic, and drug and alcohol indu... | 07/26/2005 |
| 6921756 | Inhibitors of β-lactamase The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 07/26/2005 |
| 6906006 | N-arly-substituted nitrogen-containing heterocycles, processes and novel intermediates for their preparation, and their use as herbicides and plant growth regulators Substituted triazolinone compounds of the formula: wherein the variables R1, R2, R7, R8, R12 and X are as defined in the specification are useful as herbicides, pl... | 06/14/2005 |
| 6884791 | Inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/26/2005 |
| 6753431 | Production of mixed acid anhydride and amide compound There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p (1) wherein R1, R2 and Y denote the same as defined bel... | 06/22/2004 |
| 6706698 | α-Substituted β-aminoethyl phosphonate derivatives The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and ver... | 03/16/2004 |
| 6653485 | Ortho substituted chiral phosphines and phosphinites and their use in asymmetric catalytic reactions 3,3'-Substituted chiral biaryl phosphine and phosphinite ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes are useful as catalysts in asymmetric reactions, such as, hydrogenation, hy... | 11/25/2003 |
| 6632954 | Phosphinite-oxazolines and metal complexes Compounds of formulae I and Ia, ##STR1## wherein X1 is secondary phosphino; R3 is hydrogen, a hydrocarbon radical having from 1 to 20 carbon atoms, a heterohydrocarbon radical, bonded via a carbon atom, having from 2 to 20 atoms ... | 10/14/2003 |
