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| Number | Title | Issue Date |
| RE39762 | Polyketide synthase enzymes and recombinant DNA constructs therefor Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506. ... | 08/07/2007 |
| 7126000 | Method of synthesizing camptothecin-relating compounds The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis... | 10/24/2006 |
| 7084152 | 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, ... | 08/01/2006 |
| 6909001 | Method of making tricyclic aminocyanopyridine compounds A method of making aminocyanopyridine compounds which are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 is described. ... | 06/21/2005 |
| 6750223 | 4-Anilino[2,3-b]quinoline derivatives, their preparation processes and pharmaceutical compositions comprising the same Disclosed herein are 4-anilino[2,3-b]quinoline derivatives of formula (I): wherein each of R1, R2, R3 and Y is given the definition as set forth in the Specification and Claims. These com... | 06/15/2004 |
| 6716983 | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof A process for preparing S type 2-substituted hydroxy-2-indolidinylbutyric ester compound [II]: wherein Ro is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of â... | 04/06/2004 |
| 6660862 | Polyketide synthase enzymes and recombinant DNA constructs therefor Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506. ##STR1##... | 12/09/2003 |
| 6632418 | Radioligands and their use for identifying potassium channel modulators The present invention relates to novel radioligands and test methods using those radioligands in screening compounds.... | 10/14/2003 |
| 6444820 | Process for the manufacture of camptothecin derivatives This invention discloses and claims novel intermediates and procedures for the synthesis of camptothecin derivatives, such as irinotecan, and other compounds related to the synthesis of CPT-11. Related procedures and compounds are also disclosed, such as ... | 09/03/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6384047 | Benzonaphthyridine Compounds 8,9-diethoxy-2-methyl-6-[4(p-toluenesulfonamide) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridine and 9-ethoxy-8-methoxy-2-methyl-6-[4-(p-toluenesulfonamido)phenyl]-1,2,3,4,4a, 10b-hexahydrobenzo[c][1,6]naphthyridine and medicament comp... | 05/07/2002 |
| 6319929 | Suksdorfin analogs, compositions thereof, and methods for making and using thereof The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula IV: ##STR1## wherein R20 through R26, M and Z are defined herein. The ... | 11/20/2001 |
| 6277860 | Furopyridine antibacterials This invention provides a compound of formula (I): ##STR1## or pharmaceutically acceptable salts thereof, wherein X1 and X2 are C or N, respectively; R1 and R2 are independently phenyl optionally substituted wit... | 08/21/2001 |
| 6242604 | Process for preparing a morphinan derivative A process for preparing a morphinan derivative, by providing a dihydrofuranyl bridged tetracycle halide of the formula (19) ##STR1## wherein X is halogen, R is an alkyl group of from 1 to about 10 carbon atoms, and R1 is a protecting group; and... | 06/05/2001 |
| 6121451 | Intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds This invention relates to intermediates and processes for the synthesis of camtothecin derivatives, such as irinotecan. Related procedures and compounds are disclosed, such as a method of making mappicine.... | 09/19/2000 |
| 5994545 | Process for producing optically active amides The present invention provides a process for producing decahydro(4as, 8aS)isoquinoline-3(S)-carboxamides which are useful as intermediates of Saquinavir (EP 432694). Saquinavir is an anti-AIDS agent. The comprises reacting tetrahydroisoquinoline-3(S)-carb... | 11/30/1999 |
| 5990106 | Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof This invention relates to bicyclic amino group-substituted pyridonecarboxylic acid derivatives of the general formula A--Pri esters thereof and salts thereof, wherein: Pri is a pyridonecarboxylic acid residue, and A is a bicyclic amino group represented by the... | 11/23/1999 |
| 5958970 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond... | 09/28/1999 |
| 5932732 | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof A process for preparing S type 2-substituted hydroxy-2-indolidinyl-butyric ester compound ›II!: ##STR1## wherein Ro is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of "R"(in which the nit... | 08/03/1999 |
| 5866587 | Metalloprotease inhibitors Compound of formula (I): ##STR1## in which: m, n, which are identical or different, represent 0, 1 or 2, R1, R2, which are identical or different, represent hydrogen, optionally substituted alkyl, aryl, or form with the carbon atom c... | 02/02/1999 |
| 5760050 | Antipsychotic method utilizing certain tetrahydrochromeno›3,4-c!pyridin-5-ones 1,2,3,4-Tetrahydro-chromeno›3,4-c!pyridin-5-ones of the formula ##STR1## wherein R1, R2, R3, and R5 include hydrogen, alkyl, alkoxy, hydroxy, halo, nitro, amino, and trifluoromethyl; R4 is unsub... | 06/02/1998 |
| 5726182 | Quinolizinone type compounds Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is .dbd.CR6 --; R1 is cycloalkyl of from... | 03/10/1998 |
| 5700807 | Endothelin receptor antagonists Novel compounds of the formula ##STR1## in which --Y--Z--, R1 R2, R3, R4, R5 and X have the meaning indicated and their salts show endothelin receptor-antagonistic properties.... | 12/23/1997 |
| 5696130 | Tricyclic steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 12/09/1997 |
| 5641785 | Oxazoloquinolinone derivatives, their preparation and their therapeutic application as inhibitors of monoamine oxidase 3,3a,4,5-Tetrahydro-1H-oxazolo[3,4-a]quinolin-1-one derivatives of formula (I) ##STR1## in which: n is 0 or 1, R1 represents a hydrogen atom or an ethenyl, methyl, ethyl, phenyl, hydroxymethyl or methoxymethyl group, and (i) R2 ... | 06/24/1997 |
| 5637589 | Suksdorfin, analogs, compositions thereof, and methods for making and using thereof Compounds, including compositions and methods of making and using these compounds for treating retroviral infections, are provided according to formula (G-1): ##STR1## wherein M is O or NH; Z is O, NH or S; R240, and R250 are ea... | 06/10/1997 |
| 5599816 | Quinolizinone type compounds Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is.dbd.CR6 --; R1 is cycloalkyl of from ... | 02/04/1997 |
| 5514685 | Heteroatom-containing tricyclic compounds The invention concerns the compounds of formulae ##STR1## wherein the substituents have various significances. They can be prepared by various methods, e.g. acylation, reduction, alkylation, etc. They are indicated for use as pharmaceuticals, in part... | 05/07/1996 |
| 5391745 | Methods of preparation of camptothecin analogs Substituted analoguss of camptothecin possessing cytotoxic activity towards cancer cells, of the general structure: ##STR1## wherein E is H, CO2 R, CONH2, CONHR, CONR2, acyl, or CN; X is H OH, or OR; R1, R | 02/21/1995 |
| 5346904 | Sulphonyl compound Compound of the formula I ##STR1## wherein the substituents have the meanings given in the description, are new active bronchodilators.... | 09/13/1994 |
| 5298517 | Angiotensin II receptor blocking agents This disclosure describes novel imidazole compounds having the formula: ##STR1## wherein R1 and R6 are described in the specification which have activity as angiotensin II (AII) antagonists.... | 03/29/1994 |
| 5276053 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 01/04/1994 |
| 5247090 | Tricyclic [6,6,5]-fused oxazolidinone antibacterial agents The present invention involves tricyclic-fused 6-member ring oxazolidinones ##STR1## which are useful as antibacterial agents.... | 09/21/1993 |
| 5208330 | Fused heteroalkylene quinolinamines There are disclosed compounds having the formula ##STR1## wherein n is 1-4; R is hydrogen, loweralkyl or loweralkylcarbonyl; R1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralky... | 05/04/1993 |
| 5122606 | 10,11-methylenedioxy camptothecins The invention relates to a method of producing 20(S)-camptothecin, 20(R)-camptothecin and analogs thereof. The method involves the resolution of an mixture of enantiomers of an intermediate lactone.... | 06/16/1992 |
| 5112830 | Fused heteroalkylene quinolinamines There are disclosed compounds having the formula ##STR1## wherein n is 1-4; R is hydrogen, loweralkyl or loweralkylcarbonyl; R1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralky... | 05/12/1992 |
| 5071853 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 12/10/1991 |
| 5062881 | 2-(1-substituted-2-imidazolin-2-yl)benzoic and nicotinic acids and a method for their preparation 2-(1-Substituted-2-imidazolin-2-yl)benzoic and nicotinic acids, and derivatives thereof, which are effective in the control of undesirable plant species are described. Also described are a method for the herbicidal use of the compounds and a method for th... | 11/05/1991 |
| 5061800 | Camptothecin derivatives New campotothecin derivatives and a process for preparing same are disclosed, which are represented by the general formula: ##STR1## wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or an amino, hydroxyl,... | 10/29/1991 |
| 5053512 | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives The invention relates to a method of producing 20(S)-comptothecin, 20(R)-camptothecin and analogs thereof. The method involves the resolution of an mixture of enantiomers of an intermediate lactone.... | 10/01/1991 |
