Class 546/86 - Chalcogen bonded directly to ring carbon of the tricyclo ring system

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which chalcogen (i.e., oxygen, sulfur, selenium,
No. of patents: 194
Last issue date: 05/24/2011

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Number	Title	Issue Date
7947838	Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when la...	05/24/2011
7893266	Detection of cancer cells in vitro using sigma-2 receptor ligands as radiotracers Methods for detection of cancer cells and for determining the proliferative status of cells in a tissue sample in vitro are disclosed. These methods comprise contacting a tissue sample with a radiolabeled compound or salt thereof of Formula	02/22/2011
7659400	Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when la...	02/09/2010
7649093	Naphthalene compounds as selective estrogen receptor modulators The present invention relates to cycloalkylidene compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation. ...	01/19/2010
7612206	Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors Novel benzamide compounds of Formula (I), Formula (II), and Formula (III), salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mamm...	11/03/2009
7390902	Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors Novel benzamide compounds of Formula (I), Formula (II) and Formula (III, salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal...	06/24/2008
7358364	Substituted carboxylic acids The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds inclu...	04/15/2008
7297796	Sulfamoyl benzamide derivatives and methods of their use Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or modulating ligands of ...	11/20/2007
7211572	Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt th...	05/01/2007
7189851	Condensed heterocyclic compounds as calcitonin agonists The present invention relates to novel fused heterocyclic ring system compounds and methods for their use in the treatment and prevention of diseases or conditions. ...	03/13/2007
7125886	5-HT3 receptor antagonists and methods of use The subject invention provides useful and novel 5-HT3 antagonists. The subject invention also provides methods for synthesizing the compounds of invention. The invention also provides methods for the treatment of irritable bowel syndrome and other such conditions.	10/24/2006
7122554	Carboline derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ...	10/17/2006
7109339	Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists The present invention is directed to novel compounds represented by structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R5, R6, R	09/19/2006
7084154	2-(aminomethyl) arylamide analgesics A chemical genus of 2-(aminomethyl)arylamides, which are useful as analgesics, is disclosed. The genus is represented by the formula I: A representative example is:	08/01/2006
7022856	Carboline derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ...	04/04/2006
7001911	Fused cyclic modulators of nuclear hormone receptor function The invention pertains to fused cyclic compounds having the formula, wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker, M is a bond, O, CR7R7′ or NR10	02/21/2006
6987115	Antibacterial compounds Compounds of the formula (I) are disclosed and are useful in the treatment bacterial infections: wherein: R1 is Ar or Het; R2 is C1-6a...	01/17/2006
6984646	Imidazopyridinones as p38 map kinase inhibitors The invention relates to imidazopyridinones of the formula wherein the groups R1, R2, R3, and R4 are as defined in claim 1, to the process for their preparation, to pharmaceu...	01/10/2006
6964970	Antibacterial compounds Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections: wherein: R1 is Ar or Het; R	11/15/2005
6933303	Heteroaryl-fused nitrogen heterocycles as therapeutic agents This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases, the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases mediated by PTPa...	08/23/2005
6916825	Alkylated imidazopyridine derivatives Compounds of the formula 1 in which the substituents have the meanings mentioned in the description are suitable for the prevention and treatment of gastrointestinal diseases. ...	07/12/2005
6911543	Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or co...	06/28/2005
6908928	Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions Crystalline monohydrate of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof,...	06/21/2005
6890933	Kinesin inhibitors The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cell...	05/10/2005
6849640	Therapeutic 1H-pyrido [4,3-b] indoles The present invention provides 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles and 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. These compounds are 5-HT ligands that are useful for treating diseases wherein modulation of 5-HT activity is desired. ...	02/01/2005
6841555	Lavendamycin analogs, quinoline-5,8-diones and methods of using them The invention provides novel lavendamycin analogs having the following general formula: and quinoline-5,8-diones having the following formula: Methods of making and using...	01/11/2005
6770655	5-HT3 receptor antagonists and methods of use The subject invention provides useful and novel 5-HT3 antagonists. The subject invention also provides methods for synthesizing the compounds of invention. The invention also provides methods for the treatment of irritable bowel syndrome and other such conditions.	08/03/2004
6720330	Somatostatin antagonists and agonists that act at the SST subtype 2 receptor Compounds according to the formula A—Z—W as herein described, wherein A is selected from the groups consisting of: A′—(CH2)n—, A′—(CH2)nSO2—, and A′—(CH2)nCO—, where n...	04/13/2004
6720331	1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents A composition includes a substituted dihydro- or tetrahydro-β-carboline of formula (II) or (III), wherein the aromatic ring of the carboline may include one or more substituents selected from the group consisting of hydroxy, C1-6 alkoxy, benzyloxy, C	04/13/2004
6699865	Pyrazole compositions useful as inhibitors of ERK Described herein are compounds that are useful as protein kinase inhibitors having the formula: ##STR1## where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviate...	03/02/2004
6686372	Selective 댣 adrenergic agonists The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective 댣 receptor agonists useful in the treatment of Type II diabet...	02/03/2004
6673781	Tricyclic compounds having sPLA2-inhibitory activities The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): ##STR1## wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocycl...	01/06/2004
6608098	Isoindole derivatives This invention relates to compounds represented by the general formula [I] ##STR1## wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are th...	08/19/2003
6573272	Antibacterial compounds Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections: ##STR1## wherein: R1 is Ar or Het; R2 is H, C1-6 alkyl or Ar--C0-6 alkyl; X is H, C1-4	06/03/2003
6528509	Pyrazole compositions useful as inhibitors of ERK Described herein are compounds that are useful as protein kinase inhibitors having the formula: ##STR1## where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviate...	03/04/2003
6528649	Imidazoloisoquinolines Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein n, R1, R2, R3, W, Q, and X are defined herein, which compounds bind with high selectivity a...	03/04/2003
6511987	Bicyclic and tricyclic heteroaromatic compounds Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site o...	01/28/2003
6492364	Triazolo and derivatives as chemokine inhibitors Novel triazolo derivatives represented by the following formula and pharmaceutically acceptable salts thereof, as well as chemokine inhibitors containing the same as an effective component. These are useful as therapeutic agents for allergic diseases such...	12/10/2002
6492358	ଲ-carboline derivatives useful as inhibitors of phosphodiesterase The present invention relates to novel ଲ-carboline derivatives of the general formula ##STR1## wherein all the variables are as described within the specification, useful as phosphodiesterase inhibitors. The present invention further relates to ...	12/10/2002
6451809	Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof where R1 -R4 and A are defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GAB...	09/17/2002

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Class 546/86 - Chalcogen bonded directly to ring carbon of the tricyclo ring system