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| Number | Title | Issue Date |
| 8013160 | Fluorene-based derivative and organic electroluminescence device employing the same A fluorene-based derivative having a specific structure and an organic electroluminescence device in which an organic thin film layer comprising a single layer or plural layers including at least a light emitting layer is sandwiched between a cathode and an anode, w... | 09/06/2011 |
| 7358364 | Substituted carboxylic acids The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds inclu... | 04/15/2008 |
| 7326475 | Material for organic electroluminescent device, organic electroluminescent device, illuminating device and display The present invention provides: an organic EL element exhibiting high luminance, a high external quantum efficiency and a long high temperature driving life at 50° C.; an illuminator and a display device employing the organic EL element; and a material preferably u... | 02/05/2008 |
| 7273885 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents.... | 09/25/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7223863 | Process for preparing Tadalafil and its intermediate The present invention relates an improved process for the preparation of tetrahydro-β-carboline derivative of formula (V) which is useful as an intermediate for the preparation of Tadalafil of formula (I). Moreover, the present invention relates to the process for ... | 05/29/2007 |
| 7129261 | Cytotoxic agents The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 10/31/2006 |
| 7122554 | Carboline derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 10/17/2006 |
| 7101916 | Exo-S-mecamylamine formulation and use in treatment A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is... | 09/05/2006 |
| 7053093 | Bicyclic and tricyclic hetroaromatic compounds Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high aff... | 05/30/2006 |
| 7026485 | Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 04/11/2006 |
| 7022856 | Carboline derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 04/04/2006 |
| 6998409 | Substituted 2-pyridine cyclohexane-1,4-diamine compounds Substituted 2-pyridine cyclohexane-1,4-diamine compounds, a method for their production, pharmaceutical compositions containing them, and the use of such substituted 2-pyridine cyclohexane-1,4-diamine compounds for treating pain and various other medical conditions.... | 02/14/2006 |
| 6987115 | Antibacterial compounds Compounds of the formula (I) are disclosed and are useful in the treatment bacterial infections: wherein: R1 is Ar or Het; R2 is C1-6a... | 01/17/2006 |
| 6967215 | Tetrahydrocarbazoles, a process for the preparation of those compounds, and the use thereof Tetrahydrocarbazoles of formula where Q is —SO2—; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein, are useful as an... | 11/22/2005 |
| 6964970 | Antibacterial compounds Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections: wherein: R1 is Ar or Het; R | 11/15/2005 |
| 6933303 | Heteroaryl-fused nitrogen heterocycles as therapeutic agents This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases, the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases mediated by PTPa... | 08/23/2005 |
| 6927222 | Compounds The invention provides compounds of general formula (I) wherein Q, R, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, phar... | 08/09/2005 |
| 6890933 | Kinesin inhibitors The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cell... | 05/10/2005 |
| 6861430 | β-carboline derivatives and its pharmaceutical use against depression and anxiety The invention provides compounds of formula (I) wherein R1 to R5 are as defined in the description, and their preparation. The compounds of formula (I) are useful as pharmaceuticals. ... | 03/01/2005 |
| 6858622 | Cycloalkano-indole and -azaindole derivatives Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medic... | 02/22/2005 |
| 6849640 | Therapeutic 1H-pyrido [4,3-b] indoles The present invention provides 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles and 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. These compounds are 5-HT ligands that are useful for treating diseases wherein modulation of 5-HT activity is desired. ... | 02/01/2005 |
| 6841555 | Lavendamycin analogs, quinoline-5,8-diones and methods of using them The invention provides novel lavendamycin analogs having the following general formula: and quinoline-5,8-diones having the following formula: Methods of making and using... | 01/11/2005 |
| 6809091 | Substances capable of inducing apoptosis A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and (d) [excluding uronic acid and/or uronic acid derivatives; and compou... | 10/26/2004 |
| 6734189 | Hydroxamic and carboxylic acid derivatives The invention relates to hydroxamic and carboxylic acid derivatives. Compounds of the formula: are disclosed. These compounds are useful for the treatment of diseases mediated by inhibitors of matrix metalloproteinase, A... | 05/11/2004 |
| 6720331 | 1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents A composition includes a substituted dihydro- or tetrahydro-β-carboline of formula (II) or (III), wherein the aromatic ring of the carboline may include one or more substituents selected from the group consisting of hydroxy, C1-6 alkoxy, benzyloxy, C | 04/13/2004 |
| 6686372 | Selective 댣 adrenergic agonists The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective 댣 receptor agonists useful in the treatment of Type II diabet... | 02/03/2004 |
| 6586445 | ଲ-carboline compounds The present invention is directed to compounds of the formula ##STR1## wherein the variables are defined in the specification, which bind to somatostatin receptors and block Na channels.... | 07/01/2003 |
| 6579326 | Compositions for dyeing keratin fibers, containing cationic indolizine derivatives, and dyeing process Compositions for the oxidation dyeing of keratin fibers, containing at least one oxidation base and at least one coupler chosen from indolizine derivative comprising at least one cationic group Z, Z being chosen from quaternized aliphatic chains, aliphati... | 06/17/2003 |
| 6576640 | Benzisoxazoles and phenones as 댒-antagonists The present invention concerns compounds of formula (I) ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C5-12 alkanediyl; n is 1 or 2; p is 1 and q is 2;... | 06/10/2003 |
| 6573272 | Antibacterial compounds Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections: ##STR1## wherein: R1 is Ar or Het; R2 is H, C1-6 alkyl or Ar--C0-6 alkyl; X is H, C1-4 | 06/03/2003 |
| 6534517 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 03/18/2003 |
| 6521623 | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors A compound of formula (I) ##STR1## wherein: R1 is C1 -C6 -alkyl substituted by a group selected from OH, C1 -C6 -alkoxy, --OCONHC1 -C6 -alkyl, --OCONHC1 -C6... | 02/18/2003 |
| 6514981 | Methods of modulating tyrosine protein kinase function with indolinone compounds The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indoli... | 02/04/2003 |
| 6511987 | Bicyclic and tricyclic heteroaromatic compounds Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site o... | 01/28/2003 |
| 6506768 | Tetrahydro γ-carbolines The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, optionally substituted C1-6 a... | 01/14/2003 |
| 6506759 | Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 01/14/2003 |
| 6503922 | Bridged nicotine compounds for use in the treatment of CNS pathologies Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) having selective antagonist properties at 댓댢-containing nicotinic receptor subtypes, and compositions containing these compounds. The compounds a... | 01/07/2003 |
| 6498251 | Tetrahydrobenzindole derivatives Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.... | 12/24/2002 |
| 6492358 | ଲ-carboline derivatives useful as inhibitors of phosphodiesterase The present invention relates to novel ଲ-carboline derivatives of the general formula ##STR1## wherein all the variables are as described within the specification, useful as phosphodiesterase inhibitors. The present invention further relates to ... | 12/10/2002 |
