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| Number | Title | Issue Date |
| 7605262 | Podophyllotoxin derivatives 4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4′-demethylepipodophyllotoxin. The compounds are useful for treating cancer. ... | 10/20/2009 |
| 7396837 | Antitumoral analogs of lamellarins New lamellarins are provided of the general formula III or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof ... | 07/08/2008 |
| 7354918 | Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol and applications thereof The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical —AR′ wherein A represents a heteroatom and R′ represents a group selected fr... | 04/08/2008 |
| 7270772 | Benzopyran colorants, method of manufacture, and method of use A compound of Formula (I) wherein X is hydrogen or a radical of Formula (II), R1 independently at each occurrence is a C1–C20 aliphatic radical, a C3–C10 | 09/18/2007 |
| 6835807 | Drug complex and drug delivery system A drug complex useful as a DDS compound, which is represented by the following formula: A-R—NH—Y—CH2—O—CO-Q, wherein A is a polymer as a drug carrier; R is a spacer, wherein the spacer is an amino acid or an oligopeptide comprising 2 to 8 amino ... | 12/28/2004 |
| 6811996 | DDS compounds and method for assaying the same A drug delivery system compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran polyalcohol, and a method for measuring a drug delivery... | 11/02/2004 |
| 6756381 | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof A polymorphic form of 9-nitrocamptothecin is provided, the polymorph being characterizable as having an IR spectrum with an absorption centered between 3625 cm−1 and 3675 cm−1 and containing more than a trace of water. ... | 06/29/2004 |
| 6709679 | Antineoplastic conjugates of transferin, albumin and polyethylene glycol Conjugates of transferrin, albumin and polyethylence glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approximately 5,000 and 20,0000) with at least one HS—, HO— or H2N group and cytostatic compound... | 03/23/2004 |
| 6699876 | Camptothecin analogue compounds Compound of formula (I): ##STR1## wherein: n is 0, 1 or 2, R1 represents (C3 -C11)cycloalkyl or (C3 -C11)cycloalkylalkyl, R2, R3, R4 and R5 are selec... | 03/02/2004 |
| 6608052 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceut... | 08/19/2003 |
| 6534515 | 20,21-dinor-eburnamenines A compound selected from the group consisting of all possible isomers or racemates of a compound of the formula ##STR1## wherein the various substituents are as defined in the specification and its non-toxic, pharmaceutically acceptable salts with acids o... | 03/18/2003 |
| 6509345 | Camptothecin analogue compounds Compound of formula (I): ##STR1## wherein: n is 0, 1 or 2, R1, R2, R3, R4 and R5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydro... | 01/21/2003 |
| 6407239 | Aromatic esters of camptothecins and methods to treat cancers Aromatic camptothecin ester compounds having the formula: ##STR1## are described as well as formulations containing the compounds. Methods of treating cancer and/or tumors are also disclosed.... | 06/18/2002 |
| 6376617 | Bioactive derivatives of camptothecin Water soluble polymeric conjugates of camptothecin consist essentially of N-(2-hydroxypropyl)methacryloylamide units linked via a spacer group to a residue of a camptothecin such as irinotecan or its non-soluble metabolite, 7-ethyl-10-hydroxy-camptothecin... | 04/23/2002 |
| 6306868 | Methods for inhibiting the growth of tumors with 7-substituted camptothecin derivatives Compounds of formula (I), wherein: R1 is --CN, --CH(CN)--R4, --CH.dbd.C(CN)--R4, --CH2 --CH(CN)--R4, --C(.dbd.NOH)--NH2, --C(.dbd.NH)--NH2, --CH.dbd.C(NO2)--R4 | 10/23/2001 |
| 6277992 | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof A process for preparing S type 2-substituted hydroxy-2-indolidinyl-butyric ester compound [II]: ##STR1## wherein R0 is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of "R"(in which the nitrogen ... | 08/21/2001 |
| 6252079 | Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof The present invention provides a short, convergent total synthesis of irinotecan and derivative compounds which comprises of a novel 4+1 radical annulation wherein the precursor ##STR1## is reacted with an aryl isonitrile having the formula ##STR2## ... | 06/26/2001 |
| 6228855 | Aromatic esters of camptothecins and methods to treat cancers Aromatic camptothecin ester compounds having the formula: ##STR1## are described as well as formulations containing the compounds. Methods of treating cancer and/or tumors are also disclosed.... | 05/08/2001 |
| 6187783 | Phenanthridinium derivatives A novel phenanthridinium derivative represented by general formula (A): ##STR1## wherein R1 is a substituted or unsubstituted lower aliphatic hydrocarbon group; R is an aliphatic hydrocarbon chain having 2 to 6 carbon atoms which may optionally... | 02/13/2001 |
| 6130227 | 7-Substituted camptothecin derivatives and methods for inhibiting the growth of tumor cells therewith 20S-Camptothecin derivatives in which the 7-position bears as a substituent --CN, --CH(CN)R4, --CH.dbd.C(CN)R4, --C(.dbd.NOH)NH2, --C(.dbd.NH)NH2, --CH.dbd.C(NO2)R4, --CH(CN)R5, ... | 10/10/2000 |
| 6093720 | Trans apovincaminic acid ester derivatives The invention relates to novel racemic and optically active trans apovincaminic acid ester derivatives of formula (I), ##STR1## wherein R means hydrogen or a group (a), wherein Z stands for C1-4 alkyl, optionally substituted aryl, aralkyl,... | 07/25/2000 |
| 5965566 | High molecular weight polymer-based prodrugs The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of biologically active moiety; X is an electron withdrawing group; Y and Y' are independently O or S; (n) is zero (0) or a positive integer, preferably from 1 to ab... | 10/12/1999 |
| 5880131 | High molecular weight polymer-based prodrugs High molecular weight, water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active moiety; M is X or Q; X is an electron withdrawing group; Q is a moiety containing a free electron pair positioned five or six atoms from Y'; Y and Y... | 03/09/1999 |
| 5840900 | High molecular weight polymer-based prodrugs The present invention is directed compositions of the formula: ##STR1## wherein: D is a biologically active moiety; X is an electron withdrawing group; Y and Y' are independently O or S; R1 is selected from the group consisting of H, C1-6... | 11/24/1998 |
| 5622957 | Benzopyrrolizinoquinolizinones A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R1, R2, R3, R4, R6, R7, R8, R9 and Z are... | 04/22/1997 |
| 5614549 | High molecular weight polymer-based prodrugs Water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active nucleophile; M is X or Q; x is an electron withdrawing group; Q is a moiety containing a free electron pair positioned five or six atoms from Y'; Y and Y' are oxygen or su... | 03/25/1997 |
| 5602131 | EburnanE analogues A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R1, R2, R3, R4, R5, R6, R7, R8 | 02/11/1997 |
| 5514794 | Antibody-drug conjugates Derivatized drugs are prepared with a linker consisting of a malonate, wherein the drug is linked through a methylene to the 2-position carbon of the malonate.... | 05/07/1996 |
| 5424314 | 20,21-dinoreburnamenines A compound in all racemic or optionally active forms selected from the group consisting of a compound of the formula ##STR1## where the substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable acid addition sa... | 06/13/1995 |
| 5332748 | Substituted derivatives of 20,21-dinoreburnamenine, their preparation process and the new intermediates thus obtained, their use as medicaments and the pharmaceutical compositions containing them A compound and all possible racemic or optically active isomer forms, selected from the group consisting of compound of the formula ##STR1## wherein the substituents are defined as set forth in the application as filed. Useful for treating cerebral i... | 07/26/1994 |
| 5220016 | Synthesis of navelbine analogs The invention is a de novo synthesis of the norcatharanthine moiety of navelbine. The synthesis includes condensing a Grignard reagent prepared from an amine-protected R(+)-piperidinyl methanol with an N-protected 2-methoxyoxalyl indole. The indole N-prot... | 06/15/1993 |
| 5204355 | 15-nitro-2ଲ, 3ଲ-dihydro- and 15-nitro-2ଲ,3ଲ,6,7-tetrahydrotabersonine derivatives, pharmaceutical compositions containing them and process for preparing same The invention relates to novel 15-nitro-2ଲ,3ଲ-dihydro- and 15-nitro-2ଲ,3ଲ,6,7-tetrahydrotabersonine derivatives of the formula (I), ##STR1## wherein R1 stands for hydrogen; R2 stands for hydrogen or a C | 04/20/1993 |
| 5122607 | Racemic and optically active octahydro-indolo(2,3-a) tetrahydropyranyl (2,3-c) quinolizine diester derivatives and process for preparing the same New intermediate compounds are disclosed of the formula I, ##STR1## wherein R1 and R2 are independently alkyl having 1 to 4 carbon atoms, or acid-addition salts thereof of formula Ib, ##STR2## wherein X represents an acid r... | 06/16/1992 |
| 5093337 | Substituted derivatives of 20,21-dinoreburnamenine, their use as medicaments and the pharmaceutical compositions containing them The invention concerns compounds of formula (I); ##STR1## in which R1, R2 and R3, identical or different, stand for hydrogen, halogen, alkyl or alkoxy (C1-5), hydroxy, trifluoromethyl, nitro, amino, alkylam... | 03/03/1992 |
| 5081120 | 2-,21-Dinoreburnamenines containing a 15-aminated group A compound selected from the group consisting of a compound of the formula (I): ##STR1## in which R1 and R2 are individually selected from the group consisting of hydrogen, an alkyl of 1 to 5 carbon atoms, --(CH2... | 01/14/1992 |
| 5047528 | Process of synthesis of vinblastine and vincristine The present invention relates to the synthesis of dimer alkaloid compounds, particularly those of the Catharantus (Vinca) family, from an indole unit, such as cantharanthine, and a dihydroindole unit, such as vindoline. A multi-step process is disclosed i... | 09/10/1991 |
| 5037977 | Method for production of dimeric alkaloids This invention concerns a method for the production of dimeric alkaloids, characterized by reacting of catharanthine with vindoline in the presence of Fe3+ and (1) removing or inactivating the Fe3+ and allowing the reaction product... | 08/06/1991 |
| 5034396 | Method of treating depression with optically active isomers of 20,21-dinoreburnamenines A compound selected from the group consisting of optically active isomers of a racemic compound of the formula ##STR1## wherein the 3-hydrogen and 16-hydrogen are trans and ##STR2## is selected from the group consisting of ##STR3## wit... | 07/23/1991 |
| 4980474 | Apovincaminic acid derivatives An apovincaminic acid derivative represented by the formula ##STR1## wherein n is an integer of from 2 to 11, and a pharmaceutically acceptable salt thereof are disclosed. These compounds are useful for therapy of cerebrovascular injuries, peripheral... | 12/25/1990 |
| 4939255 | Hexa-cyclic camptothecin derivatives A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumor activ... | 07/03/1990 |
